NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
DOI=10.1371/journal.pgen.0010003; PubMed=16103917 [NCBI, ExPASy, EBI, Israel, Japan]
Li X., Li W., Wang H., Cao J., Maehashi K., Hong L., Bachmanov A.A., Reed D.R., Legrand-Defretin V., Beauchamp G.K., Brand J.G.;
"Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar.";
PLoS Genet. 1:27-35(2005).

Comments

FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) (By similarity).
SUBUNIT: Forms homodimers or an heterodimer with TAS1R1.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in taste buds.
MISCELLANEOUS: Unlike most mammals domestic cats do not prefer and are unable to detect the sweetness of sugars. This is due to pseudogenization of the TAS1R2 gene which prevents the formation of the heterodimeric sweet taste receptor TAS1R2/TAS1R3. This molecular change was very likely an important event in the evolution of the cat's carnivorous behavior.
SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily [view classification].

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY819786; AAX35814.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001108019.1; -.

3D structure databases

ModBase

Q49KI5.

Protein family/group databases

GPCRDB

Q49KI5; TS1R3_FELCA.

Family and domain databases

InterPro

IPR001828; ANF_lig_bd_rcpt.
IPR000337; GPCR_3.
IPR000068; GPCR_3_Ca_sens_rcpt-rel.
IPR011500; GPCR_3_NCR.
Graphical view of domain structure.

Pfam

PF00003; 7tm_3; 1.
PF01094; ANF_receptor; 1.
PF07562; NCD3G; 1.
Pfam graphical view of domain structure.

PRINTS

PR00592; CASENSINGR.
PR00248; GPCRMGR.

PROSITE

PS00979; G_PROTEIN_RECEP_F3_1; FALSE_NEG.
PS00980; G_PROTEIN_RECEP_F3_2; FALSE_NEG.
PS00981; G_PROTEIN_RECEP_F3_3; FALSE_NEG.
PS50259; G_PROTEIN_RECEP_F3_4; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q49KI5.

Genome annotation databases

GeneID

100136905; -.

Phylogenomic databases

HOVERGEN

Q49KI5; -.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Signal; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 24`	`24`	`Potential.`
`CHAIN`	`25 865`	`841`	`Taste receptor type 1 member 3.`	`PRO_0000240183`
`TOPO_DOM`	`25 573`	`549`	`Extracellular (Potential).`
`TRANSMEM`	`574 594`	`21`	`1 (Potential).`
`TOPO_DOM`	`595 606`	`12`	`Cytoplasmic (Potential).`
`TRANSMEM`	`607 627`	`21`	`2 (Potential).`
`TOPO_DOM`	`628 642`	`15`	`Extracellular (Potential).`
`TRANSMEM`	`643 663`	`21`	`3 (Potential).`
`TOPO_DOM`	`664 685`	`22`	`Cytoplasmic (Potential).`
`TRANSMEM`	`686 706`	`21`	`4 (Potential).`
`TOPO_DOM`	`707 732`	`26`	`Extracellular (Potential).`
`TRANSMEM`	`733 753`	`21`	`5 (Potential).`
`TOPO_DOM`	`754 765`	`12`	`Cytoplasmic (Potential).`
`TRANSMEM`	`766 786`	`21`	`6 (Potential).`
`TOPO_DOM`	`787 794`	`8`	`Extracellular (Potential).`
`TRANSMEM`	`795 815`	`21`	`7 (Potential).`
`TOPO_DOM`	`816 865`	`50`	`Cytoplasmic (Potential).`
`CARBOHYD`	`134 134`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`267 267`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 865 AA [This is the length of the unprocessed precursor]

Molecular weight: 94017 Da [This is the MW of the unprocessed precursor]

CRC64: 3B3F16D6B1DAB7E9 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPGLALLGLT ALLGLTALLD HGEGATSCLS QQLRMQGDYV LGGLFPLGSA EGTGLGDGLQ 

        70         80         90        100        110        120 
PNATVCTRFS SLGLLWALAV KMAVEEINNG SALLPGLHLG YDLFDTCSEP MVAMKPSLVF 

       130        140        150        160        170        180 
MAKAGSCSIA AYCNYTQYQP RVLAVIGPHS SELALVTGKF FSFFLVPQVS YGASTDRLSN 

       190        200        210        220        230        240 
REIFPSFFRT VPSDQVQVAA MVELLEELGW NWVAAVGSDD EYGRQGLSLF SGLASARGIC 

       250        260        270        280        290        300 
IAHEGLVPLP PGSLRLGALQ GLLRQVNQSS VQVVVLFSSA HAARTLFSYS IRCKLSPKVW 

       310        320        330        340        350        360 
VASEAWLTSD LVMTLPGMPG VGTVLGFLQQ GAPMPEFPSY VRTRLALAAD PAFCASLDAE 

       370        380        390        400        410        420 
QPGLEEHVVG PRCPQCDHVT LENLSAGLLH HQTFAAYAAV YGVAQALHNT LRCNASGCPR 

       430        440        450        460        470        480 
REPVRPWQLL ENMYNVSFRA RGLALQFDAS GNVNVDYDLK LWVWQDPTPE LRTVGTFKGR 

       490        500        510        520        530        540 
LELWRSQMCW HTPGKQQPVS QCSRQCKEGQ VRRVKGFHSC CYNCVDCKAG SYQRNPDDLL 

       550        560        570        580        590        600 
CTQCDQDQWS PDRSTRCFAR KPMFLAWGEP AVLLLLALLA LALGLALAAL GLFLWHSDSP 

       610        620        630        640        650        660 
LVQASGGPRA CFGLACLGLV CLSVLLFPGQ PGPASCLAQQ PLFHLPLTGC LSTFFLQAAE 

       670        680        690        700        710        720 
IFVGSELPPS WAEKMRGRLR GPWAWLVVLL AMLAEAALCA WYLVAFPPEV VTDWRVLPTE 

       730        740        750        760        770        780 
ALVHCHVHSW ISFGLVHATN AMLAFLCFLG TFLVQSRPGR YNGARGLTFA MLAYFITWIS 

       790        800        810        820        830        840 
FVPLFANVHV AYQPAVQMGT ILLCALGILA TFHLPKCYLL LQRPELNTPE FFLEDNARAQ 

       850        860 
GSSWGQGRGE SGQKQVTPDP VTSPQ

Q49KI5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools