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[1]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[2]
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SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
DOI=10.1038/nature05957; PubMed=17611540 [NCBI, ExPASy, EBI, Israel, Japan]
Lindholm P.,
Voutilainen M.H.,
Lauren J.,
Peraenen J.,
Leppaenen V.-M.,
Andressoo J.-O.,
Lindahl M.,
Janhunen S.,
Kalkkinen N.,
Timmusk T.,
Tuominen R.K.,
Saarma M.;
"Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.";
Nature 448:73-77(2007).
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- FUNCTION: Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
- SUBCELLULAR LOCATION: Secreted.
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Isoform ID | Q49AH0-2 |
| Note: No experimental confirmation available. |
| Features which should be applied to build the isoform sequence: VSP_023986. |
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- TISSUE SPECIFICITY: Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum.
- SIMILARITY: Belongs to the ARMET family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 187 AA [This is the length of the unprocessed precursor] |
Molecular weight: 20964 Da [This is the MW of the unprocessed precursor] |
CRC64: 87460391592A10CA [This is a checksum on the sequence] |
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10 20 30 40 50 60
MWCASPVAVV AFCAGLLVSH PVLTQGQEAG GRPGADCEVC KEFLNRFYKS LIDRGVNFSL
70 80 90 100 110 120
DTIEKELISF CLDTKGKENR LCYYLGATKD AATKILSEVT RPMSVHMPAM KICEKLKKLD
130 140 150 160 170 180
SQICELKYEK TLDLASVDLR KMRVAELKQI LHSWGEECRA CAEKTDYVNL IQELAPKYAA
THPKTEL
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Q49AH0 in FASTA format |
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