NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 29609 / DSM 2027 / NCA 1503 / NCIB 8924;
PubMed=8824601 [NCBI, ExPASy, EBI, Israel, Japan]
Henstra S.A., Tolner B., ten Hoeve Duurkens R.H., Konings W.N., Robillard G.T.;
"Cloning, expression, and isolation of the mannitol transport protein from the thermophilic bacterium Bacillus stearothermophilus.";
J. Bacteriol. 178:5586-5591(1996).

Comments

CATALYTIC ACTIVITY: D-mannitol 1-phosphate + NAD⁺ = D-fructose 6-phosphate + NADH.
SIMILARITY: Belongs to the mannitol dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U18943; AAC44466.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q45421.

Ontologies

GO:0008926;	Molecular function: mannitol-1-phosphate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00196; -; 1.
PBIL [Tree]

InterPro

IPR002110; ANK.
IPR013328; DHase_multihelical.
IPR013118; Mannitol_DHase_C.
IPR000669; Mannitol_DHase_core.
IPR013131; Mannitol_DHase_N.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.

Pfam

PF01232; Mannitol_dh; 1.
PF08125; Mannitol_dh_C; 1.
Pfam graphical view of domain structure.

PRINTS

PR01415; ANKYRIN.
PR00084; MTLDHDRGNASE.

PROSITE

PS00974; MANNITOL_DHGENASE; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 382`	`382`	`Mannitol-1-phosphate 5-dehydrogenase.`	`PRO_0000170697`
`NP_BIND`	`3 14`	`12`	`NAD (By similarity).`

Sequence information

Length: 382 AA [This is the length of the unprocessed precursor]

Molecular weight: 43168 Da [This is the MW of the unprocessed precursor]

CRC64: 6A60B887A8C20052 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLAVHFGAGN IGRGFIGSLL SQSGYEVVFV DINDELVRLL KEKQEYRVII ADENRQELLI 

        70         80         90        100        110        120 
RNVSAVNSQT EREKVIDYIT KAHLITTAVG PHILPAIATI LAEGLQKRIT INKTPLHIIA 

       130        140        150        160        170        180 
CENMIGGSDV LKSHVFEKIS EADKPLFEKY YGFLNCAVDR IVPNQKHDDP LSVVVEPFFE 

       190        200        210        220        230        240 
WVIEKRNIIG AIPPIQGAHF VDDLKPYIER KLFTVNTGHA IASYLGYYKK LQTIQEAMCD 

       250        260        270        280        290        300 
QEIRSDVEKA LHESGAVLVK KYGWNENEHQ SYIQKIIQRF INPSISDEVV RVARSPIRKL 

       310        320        330        340        350        360 
GANDRLIGPA TQYYDLFGQV PHGLVKGIAA LLLFDYENDE EAVALQKTIQ ETGVEGALYQ 

       370        380 
YSQLEKDHPL VIAIKDQWQH LK

Q45421 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools