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UniProtKB/Swiss-Prot entry Q43743

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDHG1_BRANA
Primary accession number Q43743
Secondary accession number Q9T0L8
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on December 1, 2000 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 58)
Name and origin of the protein
Protein name Malate dehydrogenase 1, glyoxysomal [Precursor]
Synonym EC 1.1.1.37
Gene name
Name: MDH1
From
Brassica napus (Rape) [TaxID: 3708] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Brassica.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE.
STRAIN=cv. Andor;
TISSUE=Leaf;
Witt U., Rehberg S., Abel W.O.;
"A full-length cDNA coding for glyoxysomal malate dehydrogenase from Brassica napus L.";
(er) Plant Gene Register PGR95-124.
[2]
 NUCLEOTIDE SEQUENCE.
Imhoff U., Voetz M., Wingender R., Schnabl H., Wolf N.;
"Two genes encoding microbody malate dehydrogenase from Brassica napus.";
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X92512; CAA63268.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ242712; CAB43994.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T08015; T08015.
3D structure databases
HSSP P00346; 1MLD. [HSSP ENTRY / PDB]
SMR Q43743; 46-357.
ModBase Q43743.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR001252; Malate_DHase_AS.
IPR010097; Malate_DHase_NAD-dep_euk_g_bac.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11540:SF1; MDH_euk_g_bac; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
TIGRFAMs TIGR01772; MDH_euk_gproteo; 1.
PROSITE PS00068; MDH; 1.
BLOCKS Q43743.
Other
ProtoNet Q43743.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glyoxylate bypass; Glyoxysome; NAD; Oxidoreductase; Transit peptide; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    38  38     Glyoxysome (Potential). 
CHAIN   39   358  320     Malate dehydrogenase 1, glyoxysomal. PRO_0000018636
NP_BIND   53    59  7     NAD (By similarity). 
NP_BIND   162   164  3     NAD (By similarity). 
ACT_SITE   222   222        Proton acceptor (By similarity). 
BINDING   79    79        NAD (By similarity). 
BINDING   126   126        Substrate (By similarity). 
BINDING   132   132        Substrate (By similarity). 
BINDING   139   139        NAD (By similarity). 
BINDING   164   164        Substrate (By similarity). 
BINDING   198   198        Substrate (By similarity). 
BINDING   273   273        NAD (By similarity). 
CONFLICT   1     8        MEFRGDAY -> MPH (in Ref. 1). 
CONFLICT   68    68        M -> V (in Ref. 1; CAA63268). 
CONFLICT   72    72        V -> G (in Ref. 1; CAA63268). 
CONFLICT   151   152        AK -> GG (in Ref. 1; CAA63268). 
CONFLICT   231   231        L -> S (in Ref. 1; CAA63268). 
CONFLICT   235   235        K -> T (in Ref. 1; CAA63268). 
CONFLICT   251   251        R -> K (in Ref. 1; CAA63268). 
CONFLICT   254   254        N -> H (in Ref. 1; CAA63268). 
CONFLICT   258   258        E -> D (in Ref. 1; CAA63268). 
CONFLICT   263   263        K -> H (in Ref. 1; CAA63268). 
CONFLICT   266   266        A -> V (in Ref. 1; CAA63268). 
CONFLICT   269   279        ATLSMAYAAAK -> SPLPIILAAP (in Ref. 1; CAA63268). 
CONFLICT   306   311        ELAFFA -> DYFLC (in Ref. 1; CAA63268). 
Sequence information
Length: 358 AA [This is the length of the unprocessed precursor] Molecular weight: 37732 Da [This is the MW of the unprocessed precursor] CRC64: DC94CBC76ACEEE4A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEFRGDAYKR IAMISAHLQP SFTPQMEAKN SVMGLESCRA KGGNPGFKVA ILGAAGGIGQ 

        70         80         90        100        110        120 
SLSLLMKMNP LVSLLHLYDV VNAPGVTADV SHMDTGAVVR GFLGAKQLED ALTGMDLVII 

       130        140        150        160        170        180 
PAGVPRKPGM TRDDLFKINA GIVRTLCEGV AKCCPNAIVN LISNPVNSTV AIAAEVFKKA 

       190        200        210        220        230        240 
GTYDPKKLLG VTTLDVARAN TFVAEVLGLD PREVDVPVVG GHAGVTILPL LSQVKPPSSF 

       250        260        270        280        290        300 
TPSEIEYLTN RIQNGGTEVV EAKAGAGSAT LSMAYAAAKF ADACLRGLRG DANVIECSFV 

       310        320        330        340        350 
ASQVTELAFF ATKVRLGRTG AEEVFQLGPL NEYERVGLEK AKEELAGSIQ KGVDFIRK
Q43743 in FASTA format

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