[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Venom gland; Suck R., Fiebig H., Cromwell O.; "cDNA cloning of phospholipase A1 from Vespula germanica (Ves g 1)."; Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities (By similarity).
CATALYTIC ACTIVITY: Phosphatidylcholine + H₂O = 2-acylglycerophosphocholine + a carboxylate.
CATALYTIC ACTIVITY: Phosphatidylcholine + H₂O = 1-acylglycerophosphocholine + a carboxylate.
SUBUNIT: Monomer (By similarity).
SUBCELLULAR LOCATION: Secreted (By similarity).
TISSUE SPECIFICITY: Expressed by the venom gland.
PTM: Contains six disulfide bonds (By similarity).
ALLERGEN: Causes an allergic reaction in human (By similarity).
SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.

Copyright

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Cross-references

Sequence databases

EMBL

AM083318; CAJ28931.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q3ZU95.

Ontologies

GO:0004623;	Molecular function: phospholipase A2 activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR002334; Dol/Ves_allerg.
IPR000734; Lipase.
IPR008262; Lipase_AS.
IPR013818; Lipase_N.
Graphical view of domain structure.

PANTHER

PTHR11610; Lipase; 1.

Pfam

PF00151; Lipase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00825; DOLALLERGEN.

PROSITE

PS00120; LIPASE_SER; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Allergen; Hydrolase; Lipid degradation; Secreted.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 300`	`300`	`Phospholipase A1.`	`PRO_5000076445`
`ACT_SITE`	`137 137`		`Charge relay system (By similarity).`
`ACT_SITE`	`165 165`		`Charge relay system (By similarity).`
`ACT_SITE`	`229 229`		`Charge relay system (By similarity).`

Sequence information

Length: 300 AA [This is the length of the unprocessed precursor]

Molecular weight: 33240 Da [This is the MW of the unprocessed precursor]

CRC64: CC0E3A26CE8B7D04 [This is a checksum on the sequence]

        10         20         30         40         50         60 
GPKCPFNTDT VSMIIETREN RNRDLYTLQT LQNHPEFKEK TITRPVVFIT HGFTSSASET 

        70         80         90        100        110        120 
NFINLSKALV DKDNYMVISI DWQTAACTNE AAGLKYLYYP TAASNTRLVG QYIATITQKL 

       130        140        150        160        170        180 
VKQYKISMAN IRLIGHSLGA HVSGFAGKKV QELKLGKYSE IIGLDPAGPS FSSNKCSDRL 

       190        200        210        220        230        240 
CETDAEYVQI LHTSNHLGTE RILGTVDFYM NNGKNQPGCG RFFTEVCSHS RAVIYMAECI 

       250        260        270        280        290        300 
KHECCLIGIP KSKSSQPISS CTKQECVCVG LNAKKYPSRG SFYVPVESTA PFCNNKGKII

Q3ZU95 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools