[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=Crossbred X Angus; TISSUE=Ileum; NIH - Mammalian Gene Collection (MGC) project; Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the NADPH-dependent reduction of a variety of aldehydes to their corresponding alcohols (By similarity).
CATALYTIC ACTIVITY: An alcohol + NADP⁺ = an aldehyde + NADPH.
SUBUNIT: Monomer (By similarity).
SIMILARITY: Belongs to the aldo/keto reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC102166; AAI02167.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001069981.1; -.

UniGene

Bt.49266

3D structure databases

SMR

Q3ZCJ2; 2-325.

ModBase

Q3ZCJ2.

Family and domain databases

InterPro

IPR001395; Aldo/ket_red.
Graphical view of domain structure.

Gene3D

G3DSA:3.20.20.100; Aldo/ket_red; 1.

PANTHER

PTHR11732; Aldo/ket_red; 1.

Pfam

PF00248; Aldo_ket_red; 1.
Pfam graphical view of domain structure.

PRINTS

PR00069; ALDKETRDTASE.

ProDom

PD000288; Aldo/ket_red; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00798; ALDOKETO_REDUCTASE_1; 1.
PS00062; ALDOKETO_REDUCTASE_2; 1.
PS00063; ALDOKETO_REDUCTASE_3; 1.

BLOCKS

Q3ZCJ2.

Genome annotation databases

Ensembl

ENSBTAG00000000497; Bos taurus. [Contig view]

GeneID

618607; -.

KEGG

bta:618607; -.

Phylogenomic databases

HOVERGEN

Q3ZCJ2; -.

Other

ProtoNet

Q3ZCJ2.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acetylation; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 325`	`324`	`Alcohol dehydrogenase [NADP+].`	`PRO_0000287129`
`NP_BIND`	`211 273`	`63`	`NADP (By similarity).`
`ACT_SITE`	`50 50`		`Proton donor.`
`BINDING`	`113 113`		`Substrate (By similarity).`
`SITE`	`80 80`	`1`	`Lowers pKa of active site Tyr (By similarity).`
`MOD_RES`	`2 2`		`N-acetylalanine (By similarity).`

Sequence information

Length: 325 AA [This is the length of the unprocessed precursor]

Molecular weight: 36617 Da [This is the MW of the unprocessed precursor]

CRC64: 66584EFE75C03036 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAASCILLHT GQKMPLIGLG TWKSDPGQVK AAIKYALSVG YRHIDCAAIY GNETEIGEAL 

        70         80         90        100        110        120 
KENVGPGKLV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER 

       130        140        150        160        170        180 
GDSPFPKNAD GTIRYDSTHY KETWRALEAL VAKGLVRALG LSNFNSRQID DVLSVASVRP 

       190        200        210        220        230        240 
AVLQVECHPY LAQNELIAHC QARNLEVTAY SPLGSSDRAW RDPEEPVLLK EPVVLALAEK 

       250        260        270        280        290        300 
HGRSPAQILL RWQVQRKVSC IPKSVTPSRI LENIQVFDFT FSPEEMKQLD ALNKNLRFIV 

       310        320 
PMLTVDGKRV PRDAGHPLYP FNDPY

Q3ZCJ2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools