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UniProtKB/Swiss-Prot entry Q3UHJ0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AAK1_MOUSE
Primary accession number Q3UHJ0
Secondary accession numbers Q3TY53 Q6ZPZ6 Q80XP6
Integrated into Swiss-Prot on October 3, 2006
Sequence was last modified on October 3, 2006 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 33)
Name and origin of the protein
Protein name AP2-associated protein kinase 1
Synonyms EC 2.7.11.1
Adaptor-associated kinase 1
Gene name
Name: Aak1
Synonyms: Kiaa1048
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=C57BL/6J;
TISSUE=Visual cortex;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 417-959 (ISOFORM 1).
TISSUE=Brain;
DOI=10.1093/dnares/10.4.167; PubMed=14621295 [NCBI, ExPASy, EBI, Israel, Japan]
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.;
"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.";
DNA Res. 10:167-180(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 473-959 (ISOFORM 2).
STRAIN=C57BL/6;
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; THR-604; THR-618; SER-621; SER-635; SER-650; SER-729; SER-935 AND SER-936, AND MASS SPECTROMETRY.
TISSUE=Brain cortex;
DOI=10.1074/mcp.M600046-MCP200; PubMed=17114649 [NCBI, ExPASy, EBI, Israel, Japan]
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.";
Mol. Cell. Proteomics 6:283-293(2007).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-635; THR-638 AND SER-650, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1073/pnas.0609836104; PubMed=17242355 [NCBI, ExPASy, EBI, Israel, Japan]
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK147363; BAE27867.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK158879; BAE34710.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK129272; BAC98082.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC043125; AAH43125.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001035195.1; -.
NP_808430.2; -.
UniGene Mm.221038
3D structure databases
ModBase Q3UHJ0.
Protein-protein interaction databases
IntAct Q3UHJ0; -.
PTM databases
PhosphoSite Q3UHJ0; -.
Organism-specific databases
MGI MGI:1098687; Aak1.
Gene expression databases
ArrayExpress Q3UHJ0; -.
CleanEx MM_AAK1; -.
GermOnline ENSMUSG00000057230; Mus musculus.
Family and domain databases
InterPro IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.
Pfam PF00069; Pkinase; 1.
Pfam graphical view of domain structure.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q3UHJ0.
Genome annotation databases
Ensembl ENSMUSG00000057230; Mus musculus. [Contig view]
GeneID 269774; -.
KEGG mmu:269774; -.
Phylogenomic databases
HOVERGEN Q3UHJ0; -.
Other
SOURCE Aak1; Mus musculus.
ROUGE KIAA1048.
ProtoNet Q3UHJ0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; ATP-binding; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Serine/threonine-protein kinase; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   959  959     AP2-associated protein kinase 1. PRO_0000250579
DOMAIN   46   315  270     Protein kinase. 
NP_BIND   52    60  9     ATP (By similarity). 
COMPBIAS   22    25  4     Poly-Gly. 
COMPBIAS   397   612  216     Gln-rich. 
COMPBIAS   656   661  6     Poly-Ala. 
ACT_SITE   176   176        Proton acceptor (By similarity). 
BINDING   74    74        ATP (By similarity). 
MOD_RES   21    21        Phosphoserine. 
MOD_RES   389   389        Phosphothreonine (By similarity). 
MOD_RES   604   604        Phosphothreonine. 
MOD_RES   618   618        Phosphothreonine. 
MOD_RES   621   621        Phosphoserine. 
MOD_RES   635   635        Phosphoserine. 
MOD_RES   638   638        Phosphothreonine. 
MOD_RES   650   650        Phosphoserine. 
MOD_RES   668   668        Phosphoserine (By similarity). 
MOD_RES   674   674        Phosphoserine (By similarity). 
MOD_RES   729   729        Phosphoserine. 
MOD_RES   935   935        Phosphoserine. 
MOD_RES   936   936        Phosphoserine. 
VAR_SEQ   509   589        Missing (in isoform 2). VSP_020670
CONFLICT   79    79        N -> K (in Ref. 1; BAE27867). 
CONFLICT   686   686        N -> S (in Ref. 2; BAC98082). 
Sequence information
Length: 959 AA [This is the length of the unprocessed precursor] Molecular weight: 103346 Da [This is the MW of the unprocessed precursor] CRC64: B7D666EFD56D097A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKKFFDSRRE QGSSGLGSGS SGGGGSSSGL GSGYIGRVFG IGRQQVTVDE VLAEGGFALV 

        70         80         90        100        110        120 
FLVRTSNGVK CALKRMFVNN EHDLQVCKRE IQIMRDLSGH KNIVGYIDSS INNVSSGDVW 

       130        140        150        160        170        180 
EVLILMDFCR GGQVVNLMNQ RLQTGFTENE VLQIFCDTCE AVARLHQCKT PIIHRDLKVE 

       190        200        210        220        230        240 
NILLHDRGHY VLCDFGSATN KFQNPQAEGV NAVEDEIKKY TTLSYRAPEM VNLYSGKIIT 

       250        260        270        280        290        300 
TKADIWALGC LLYKLCYFTL PFGESQVAIC DGSFTIPDNS RYSQDMHCLI RYMLEPDPDK 

       310        320        330        340        350        360 
RPDIYQVSYF SFKLLKKECP VPNVQNSPIP AKLPEPVKAS EAAVKKTQPK ARLTDPIPTT 

       370        380        390        400        410        420 
ETSIAPRQRP KAGQTQPNPG ILPIQPALTP RKRATVQPLP QAAGPSNQPG LLPSVSQPKA 

       430        440        450        460        470        480 
QATPSQPLQS SQPKQPQAPP TPQQTPATQT QGLPTQAQAT PQHQQQHLLK QQQQQQQQPQ 

       490        500        510        520        530        540 
QPTAPPQPAG TFYQQQQQQQ QQQAQTQQFQ AVHPAAQQPV TAQFPVGSQG GAQQQLMQNF 

       550        560        570        580        590        600 
YHQQQQQQQQ QQQLMAQQAA LQQKTAVVVP QSQAQPATAP QAAAAQEPGQ IQAPVRQQPK 

       610        620        630        640        650        660 
VQTTPPPTIQ GQKVGSLTPP SSPKTQRAGH RRILSDVTHS AVFGVPASKS TQLLQAAAAE 

       670        680        690        700        710        720 
ASLNKSKSAT TTPSGSPRTS QQNVSNASEG STWNPFDDDN FSKLTAEELL NKDFAKLGEG 

       730        740        750        760        770        780 
KLPEKLGGSA ESLIPGFQPT QGDAFTTPSF SAGTAEKRKG GQAVDSGIPL LSVSDPFIPL 

       790        800        810        820        830        840 
QVPDAPEKLI EGLKSPDTSL LLPDLLPMTD PFGSTSDAVI DKADVAVESL IPGLEPPVAQ 

       850        860        870        880        890        900 
RLPSQTESVT SNRTDSLTGE DSLLDCSLLS NPTAGLLEEF APIALSAPTH KAAEDSNLIS 

       910        920        930        940        950 
GFGVAEGSEK VAEDEFDPIP VLITKNTQGG HSRNSSGSSE SSLPNLARSL LLVDQLIDL 

Q3UHJ0 in FASTA format

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