[1]	NUCLEOTIDE SEQUENCE. STRAIN=NOD; DOI=10.1016/S0076-6879(99)03004-9; PubMed=10349636 [NCBI, ExPASy, EBI, Israel, Japan] Carninci P., Hayashizaki Y.; "High-efficiency full-length cDNA cloning."; Methods Enzymol. 303:19-44(1999).
[2]	NUCLEOTIDE SEQUENCE. STRAIN=NOD; DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan] Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.; "The transcriptional landscape of the mammalian genome."; Science 309:1559-1563(2005).
[3]	NUCLEOTIDE SEQUENCE. STRAIN=NOD; DOI=10.1126/science.1112009; PubMed=16141073 [NCBI, ExPASy, EBI, Israel, Japan] RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; "Antisense Transcription in the Mammalian Transcriptome."; Science 309:1564-1566(2005).
[4]	NUCLEOTIDE SEQUENCE. STRAIN=NOD; DOI=10.1038/nature01266; PubMed=12466851 [NCBI, ExPASy, EBI, Israel, Japan] Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T., Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J., Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W., Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S., Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S., Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J., Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D., Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L., Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A., Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H., Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G., Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S., Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M., Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K., Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M., Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C., Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L., Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N., Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K., Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S., Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I., Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A., Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J., Birney E., Hayashizaki Y.; "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."; Nature 420:563-573(2002).
[5]	NUCLEOTIDE SEQUENCE. STRAIN=NOD; DOI=10.1038/35055500; PubMed=11217851 [NCBI, ExPASy, EBI, Israel, Japan] Kawai J., Shinagawa A., Shibata K., Yoshino M., Itoh M., Ishii Y., Arakawa T., Hara A., Fukunishi Y., Konno H., Adachi J., Fukuda S., Aizawa K., Izawa M., Nishi K., Kiyosawa H., Kondo S., Yamanaka I., Saito T., Okazaki Y., Gojobori T., Bono H., Kasukawa T., Saito R., Kadota K., Matsuda H.A., Ashburner M., Batalov S., Casavant T., Fleischmann W., Gaasterland T., Gissi C., King B., Kochiwa H., Kuehl P., Lewis S., Matsuo Y., Nikaido I., Pesole G., Quackenbush J., Schriml L.M., Staubli F., Suzuki R., Tomita M., Wagner L., Washio T., Sakai K., Okido T., Furuno M., Aono H., Baldarelli R., Barsh G., Blake J., Boffelli D., Bojunga N., Carninci P., de Bonaldo M.F., Brownstein M.J., Bult C., Fletcher C., Fujita M., Gariboldi M., Gustincich S., Hill D., Hofmann M., Hume D.A., Kamiya M., Lee N.H., Lyons P., Marchionni L., Mashima J., Mazzarelli J., Mombaerts P., Nordone P., Ring B., Ringwald M., Rodriguez I., Sakamoto N., Sasaki H., Sato K., Schoenbach C., Seya T., Shibata Y., Storch K.-F., Suzuki H., Toyo-oka K., Wang K.H., Weitz C., Whittaker C., Wilming L., Wynshaw-Boris A., Yoshida K., Hasegawa Y., Kawaji H., Kohtsuki S., Hayashizaki Y.; "Functional annotation of a full-length mouse cDNA collection."; Nature 409:685-690(2001).
[6]	NUCLEOTIDE SEQUENCE. STRAIN=NOD; DOI=10.1101/gr.145100; PubMed=11042159 [NCBI, ExPASy, EBI, Israel, Japan] Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."; Genome Res. 10:1617-1630(2000).
[7]	NUCLEOTIDE SEQUENCE. STRAIN=NOD; DOI=10.1101/gr.152600; PubMed=11076861 [NCBI, ExPASy, EBI, Israel, Japan] Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; "RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."; Genome Res. 10:1757-1771(2000).
[8]	NUCLEOTIDE SEQUENCE. STRAIN=NOD; Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.; Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
[9]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=PCR rescued clones; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the G-protein coupled receptor 1 family [view classification].

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC105643; AAI05644.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AK170303; BAE41700.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00653496; -.

UniGene

Mm.14302

3D structure databases

ModBase

Q3TDA4.

Protein family/group databases

GPCRDB

Q3TDA4; Q3TDA4_MOUSE.

Organism-specific databases

MGI

MGI:107182; Ccr5.

Gene expression databases

ArrayExpress

Q3TDA4; -.

Bgee

Q3TDA4; -.

Ontologies

GO:0005768;	Cellular component: endosome (inferred from electronic annotation from Compara).
GO:0009897;	Cellular component: external side of plasma membrane (inferred from direct assay from MGI).
GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0016493;	Molecular function: C-C chemokine receptor activity (inferred from direct assay from MGI).
GO:0042742;	Biological process: defense response to bacterium (inferred from electronic annotation from Compara).
GO:0007186;	Biological process: G-protein coupled receptor protein signaling pathway (inferred from electronic annotation from InterPro).
GO:0002437;	Biological process: inflammatory response to antigenic stimulus (inferred from electronic annotation from Compara).
QuickGo view.

Family and domain databases

InterPro

IPR000276; 7TM_GPCR_Rhodpsn.
IPR002240; CC_5_rcpt.
IPR000355; Chmkine_rcpt.
IPR017452; GPCR_Rhodpsn_supfam.
Graphical view of domain structure.

PANTHER

PTHR19264:SF204; CC_5_rcpt; 1.

Pfam

PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.

PRINTS

PR00657; CCCHEMOKINER.
PR01110; CHEMOKINER5.
PR00237; GPCRRHODOPSN.

PROSITE

PS00237; G_PROTEIN_RECEP_F1_1; 1.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSMUSG00000079227; Mus musculus. [Contig view]

Phylogenomic databases

HOVERGEN

Q3TDA4; -.

Other

Ccr5; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane; Receptor; Transducer; Transmembrane.

Features

None

Sequence information

Length: 354 AA

Molecular weight: 40837 Da

CRC64: C4F3AAFD1A6F3BE8 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDFQGSVPTY IYDIDYGMSA PCQKINVKQI AAQLLPPLYS LVFIFGFVGN MMVFLILISC 

        70         80         90        100        110        120 
KRLKSMTDIY LLNLAISDLL FLLTLPFWAH YAANEWVFGN IMCKVFTGVY HIGYFGGIFF 

       130        140        150        160        170        180 
IILLTIDRYL AIVHAVFALK VRTVNFGVIT SVVTWVVAVS ASLPEIIFTR SQKEGFHYTC 

       190        200        210        220        230        240 
SPHFLHTQYH FWKSFQTLKM VILSLILPLL VMIICYSGIL HTLFRCRNEK KRHRAVRLIF 

       250        260        270        280        290        300 
AIMIVYFLFW TPYNIVLLLT TFQEFFGLNN CSSSNRLDQA MQATETLGMT HCCLNPVIYA 

       310        320        330        340        350 
FVGEKFRSYL SVFFRKHIVK RFCKRCSIFQ QDNPDRASSV YTRSTGEHEV STGL

Q3TDA4 in FASTA format

View entry in raw text format (no links)
Request for annotation of this UniProtKB/TrEMBL entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools