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UniProtKB/Swiss-Prot entry Q3SYB3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FX4L6_HUMAN
Primary accession number Q3SYB3
Secondary accession numbers B2RPC4 Q4V336
Integrated into Swiss-Prot on September 11, 2007
Sequence was last modified on January 15, 2008 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 36)
Name and origin of the protein
Protein name Forkhead box protein D4-like 6
Synonym FOXD4-like 6
Gene name
Name: FOXD4L6
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02465; PubMed=15164053 [NCBI, ExPASy, EBI, Israel, Japan]
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.;
"DNA sequence and analysis of human chromosome 9.";
Nature 429:369-374(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX255923; CAI94919.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC103887; AAI03888.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC137365; AAI37366.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC137366; AAI37367.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00654829; -.
RefSeq NP_001078945.1; -.
UniGene Hs.652377
3D structure databases
SMR Q3SYB3; 108-203.
ModBase Q3SYB3.
Organism-specific databases
GeneCards GC09M068489; -.
HGNC HGNC:31986; FOXD4L6.
GenAtlas FOXD4L6.
HPA HPA012836; -.
Gene expression databases
CleanEx HS_FOXD4L6; -.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-SubCell).
GO:0043565; Molecular function: sequence-specific DNA binding (inferred from electronic annotation from InterPro).
GO:0003700; Molecular function: transcription factor activity (inferred from electronic annotation from InterPro).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0006350; Biological process: transcription (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001766; TF_fork_head.
IPR018122; TF_fork_head_CS.
IPR011991; Wing_hlx_DNA_bd.
Graphical view of domain structure.
Gene3D G3DSA:1.10.10.10; Wing_hlx_DNA_bd; 1.
PANTHER PTHR11829; Fork_box_protein; 1.
Pfam PF00250; Fork_head; 1.
Pfam graphical view of domain structure.
PRINTS PR00053; FORKHEAD.
ProDom PD000425; TF_Fork_head; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00339; FH; 1.
SMART graphical view of domain structure.
PROSITE PS00657; FORK_HEAD_1; 1.
PS00658; FORK_HEAD_2; 1.
PS50039; FORK_HEAD_3; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q3SYB3; -.
Genome annotation databases
Ensembl ENSG00000204793; Homo sapiens. [Contig view]
GeneID 653404; -.
KEGG hsa:653404; -.
Phylogenomic databases
HOGENOM Q3SYB3; -.
HOVERGEN Q3SYB3; -.
Other
NextBio 123194; -.
ProtoNet Q3SYB3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
DNA-binding; Nucleus; Transcription; Transcription regulation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   417  417     Forkhead box protein D4-like 6. PRO_0000301979
DNA_BIND   108   202  95     Fork-head. 
COMPBIAS   211   267  57     Pro-rich. 
CONFLICT   416   416        P -> R (in Ref. 2; CAI94919). 
Sequence information
Length: 417 AA [This is the length of the unprocessed precursor] Molecular weight: 45787 Da [This is the MW of the unprocessed precursor] CRC64: 0A21FCC4EC1D66CE [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF LEQSLQPGLQ 

        70         80         90        100        110        120 
VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA 

       130        140        150        160        170        180 
ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN 

       190        200        210        220        230        240 
YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP 

       250        260        270        280        290        300 
APPQPVPGAY PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS 

       310        320        330        340        350        360 
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG ATATCSSDHQ 

       370        380        390        400        410 
ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL PPRARCWAGT CRPRRPC 

Q3SYB3 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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