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UniProtKB/Swiss-Prot entry Q3AB86

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DXR_CARHZ
Primary accession number Q3AB86
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on November 22, 2005 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 21)
Name and origin of the protein
Protein name 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Synonyms DXP reductoisomerase
EC 1.1.1.267
1-deoxyxylulose-5-phosphate reductoisomerase
2-C-methyl-D-erythritol 4-phosphate synthase
Gene name
Name: dxr
OrderedLocusNames: CHY_1778
From
Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [TaxID: 246194] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales; Thermoanaerobacteraceae; Carboxydothermus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1371/journal.pgen.0010065; PubMed=16311624 [NCBI, ExPASy, EBI, Israel, Japan]
Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A.;
"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901.";
PLoS Genet. 1:563-574(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000141; ABB16017.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_360598.1; -.
3D structure databases
ModBase Q3AB86.
Enzyme and pathway databases
BioCyc CHYD246194:CHY_1778-MON; -.
Ontologies
GO
GO:0030604; Molecular function: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity (inferred from electronic annotation from HAMAP).
GO:0046872; Molecular function: metal ion binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0016114; Biological process: terpenoid biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00183; -; 1.
PBIL [Tree]
InterPro IPR003821; DXP_reductoisomerase.
IPR013644; DXP_reductoisomerase_C.
IPR013512; DXP_reductoisomerase_N.
Graphical view of domain structure.
Pfam PF08436; DXP_redisom_C; 1.
PF02670; DXP_reductoisom; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF006205; Dxp_reductismrs; 1.
TIGRFAMs TIGR00243; Dxr; 1.
ProtoNet Q3AB86.
Genome annotation databases
GeneID 3728128; -.
GenomeReviews CP000141_GR; CHY_1778.
KEGG chy:CHY_1778; -.
NMPDR fig|246194.3.peg.2222; -.
TIGR CHY_1778; -.
Phylogenomic databases
HOGENOM Q3AB86; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Isoprene biosynthesis; Metal-binding; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   384  384     1-deoxy-D-xylulose 5-phosphate reductoisomerase. PRO_1000020241
NP_BIND   7    36  30     NADP (By similarity). 
METAL   147   147        Divalent metal cation (By similarity). 
METAL   149   149        Divalent metal cation (By similarity). 
METAL   218   218        Divalent metal cation (By similarity). 
BINDING   123   123        Substrate (By similarity). 
BINDING   149   149        Substrate (By similarity). 
BINDING   173   173        Substrate (By similarity). 
BINDING   196   196        Substrate (By similarity). 
BINDING   218   218        Substrate (By similarity). 
Sequence information
Length: 384 AA [This is the length of the unprocessed precursor] Molecular weight: 42605 Da [This is the MW of the unprocessed precursor] CRC64: 892F9C57A0311087 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKKLVILGST GSIGRQSLEV IEFFPDKFSV VALAAAKNGK LLLEQCLRFK VKHAFLADEE 

        70         80         90        100        110        120 
SYKTYYQEFK NHGILLTTGS KELLNLALLP GVDGIITAIP GTICLLPTIE ALKAGKIIYL 

       130        140        150        160        170        180 
ANKETMVAAG EIITPLMKLG ENLLPVDSEH SAIFQALRGE KLAWVKKLLI TASGGPFREY 

       190        200        210        220        230        240 
TLEQLKNVTV AEALKHPRWK MGNKITIDSA TLMNKGLEII EAHFLFQIPY EKIEPVIHPQ 

       250        260        270        280        290        300 
SVIHSLVEFY DGSVLAQLGL PDMRHPIQYA LTYPERFPNN LPGLNLTEIG VLSFEKPDYE 

       310        320        330        340        350        360 
RFPALKLAIQ AGKAGNIYPA VLNAANEIAV EAFLAGKIKF LEIAQIVEKV LNCFSPVKMD 

       370        380 
LETILEVDFR ARELARKFIG GEHQ
Q3AB86 in FASTA format

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