[1]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/S0092-8674(00)80099-9; PubMed=8706132 [NCBI, ExPASy, EBI, Israel, Japan]
Connelly C.,
Hieter P.;
"Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression.";
Cell 86:275-285(1996).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INTERACTION WITH UFO.
STRAIN=cv. Columbia;
DOI=10.1046/j.1365-313x.1999.00617.x; PubMed=10607296 [NCBI, ExPASy, EBI, Israel, Japan]
Samach A.,
Klenz J.E.,
Kohalmi S.E.,
Risseeuw E.,
Haughn G.W.,
Crosby W.L.;
"The UNUSUAL FLORAL ORGANS gene of Arabidopsis thaliana is an F-box protein required for normal patterning and growth in the floral meristem.";
Plant J. 20:433-445(1999).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Landsberg erecta;
DOI=10.1007/s004380051173; PubMed=10778750 [NCBI, ExPASy, EBI, Israel, Japan]
Schouten J.,
de Kam R.J.,
Fetter K.,
Hoge J.H.C.;
"Overexpression of Arabidopsis thaliana SKP1 homologues in yeast inactivates the Mig1 repressor by destabilising the F-box protein Grr1.";
Mol. Gen. Genet. 263:309-319(2000).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1038/35048500; PubMed=11130712 [NCBI, ExPASy, EBI, Israel, Japan]
Theologis A.,
Ecker J.R.,
Palm C.J.,
Federspiel N.A.,
Kaul S.,
White O.,
Alonso J.,
Altafi H.,
Araujo R.,
Bowman C.L.,
Brooks S.Y.,
Buehler E.,
Chan A.,
Chao Q.,
Chen H.,
Cheuk R.F.,
Chin C.W.,
Chung M.K.,
Conn L., ![]()
Conway A.B.,
Conway A.R.,
Creasy T.H.,
Dewar K.,
Dunn P.,
Etgu P.,
Feldblyum T.V.,
Feng J.-D.,
Fong B.,
Fujii C.Y.,
Gill J.E.,
Goldsmith A.D.,
Haas B.,
Hansen N.F.,
Hughes B.,
Huizar L.,
Hunter J.L.,
Jenkins J.,
Johnson-Hopson C.,
Khan S.,
Khaykin E.,
Kim C.J.,
Koo H.L.,
Kremenetskaia I.,
Kurtz D.B.,
Kwan A.,
Lam B.,
Langin-Hooper S.,
Lee A.,
Lee J.M.,
Lenz C.A.,
Li J.H.,
Li Y.-P.,
Lin X.,
Liu S.X.,
Liu Z.A.,
Luros J.S.,
Maiti R.,
Marziali A.,
Militscher J.,
Miranda M.,
Nguyen M.,
Nierman W.C.,
Osborne B.I.,
Pai G.,
Peterson J.,
Pham P.K.,
Rizzo M.,
Rooney T.,
Rowley D.,
Sakano H.,
Salzberg S.L.,
Schwartz J.R.,
Shinn P.,
Southwick A.M.,
Sun H.,
Tallon L.J.,
Tambunga G.,
Toriumi M.J.,
Town C.D.,
Utterback T.,
Van Aken S.,
Vaysberg M.,
Vysotskaia V.S.,
Walker M.,
Wu D.,
Yu G.,
Fraser C.M.,
Venter J.C.,
Davis R.W.;
"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
Nature 408:816-820(2000).
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
DOI=10.1126/science.1088305; PubMed=14593172 [NCBI, ExPASy, EBI, Israel, Japan]
Yamada K.,
Lim J.,
Dale J.M.,
Chen H.,
Shinn P.,
Palm C.J.,
Southwick A.M.,
Wu H.C.,
Kim C.J.,
Nguyen M.,
Pham P.K.,
Cheuk R.F.,
Karlin-Newmann G.,
Liu S.X.,
Lam B.,
Sakano H.,
Wu T.,
Yu G.,
Miranda M., ![]()
Quach H.L.,
Tripp M.,
Chang C.H.,
Lee J.M.,
Toriumi M.J.,
Chan M.M.,
Tang C.C.,
Onodera C.S.,
Deng J.M.,
Akiyama K.,
Ansari Y.,
Arakawa T.,
Banh J.,
Banno F.,
Bowser L.,
Brooks S.Y.,
Carninci P.,
Chao Q.,
Choy N.,
Enju A.,
Goldsmith A.D.,
Gurjal M.,
Hansen N.F.,
Hayashizaki Y.,
Johnson-Hopson C.,
Hsuan V.W.,
Iida K.,
Karnes M.,
Khan S.,
Koesema E.,
Ishida J.,
Jiang P.X.,
Jones T.,
Kawai J.,
Kamiya A.,
Meyers C.,
Nakajima M.,
Narusaka M.,
Seki M.,
Sakurai T.,
Satou M.,
Tamse R.,
Vaysberg M.,
Wallender E.K.,
Wong C.,
Yamamura Y.,
Yuan S.,
Shinozaki K.,
Davis R.W.,
Theologis A.,
Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis genome.";
Science 302:842-846(2003).
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[6]
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NUCLEOTIDE SEQUENCE [MRNA] OF 13-160, DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
STRAIN=cv. Columbia;
DOI=10.1007/s004250050265; PubMed=9530878 [NCBI, ExPASy, EBI, Israel, Japan]
Porat R.,
Lu P.,
O'Neill S.D.;
"Arabidopsis SKP1, a homologue of a cell cycle regulator gene, is predominantly expressed in meristematic cells.";
Planta 204:345-351(1998).
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[7]
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FUNCTION.
DOI=10.1002/(SICI)1520-6408(1999)25:3<209::AID-DVG4>3.3.CO;2-F; PubMed=10528262 [NCBI, ExPASy, EBI, Israel, Japan]
Zhao D.,
Yang M.,
Solava J.,
Ma H.;
"The ASK1 gene regulates development and interacts with the UFO gene to control floral organ identity in Arabidopsis.";
Dev. Genet. 25:209-223(1999).
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[8]
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FUNCTION, AND INTERACTION WITH TIR1.
DOI=10.1101/gad.13.13.1678; PubMed=10398681 [NCBI, ExPASy, EBI, Israel, Japan]
Gray W.M.,
del Pozo J.C.,
Walker L.,
Hobbie L.,
Risseeuw E.,
Banks T.,
Crosby W.L.,
Yang M.,
Ma H.,
Estelle M.;
"Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana.";
Genes Dev. 13:1678-1691(1999).
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[9]
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FUNCTION.
DOI=10.1073/pnas.96.20.11416; PubMed=10500191 [NCBI, ExPASy, EBI, Israel, Japan]
Yang M.,
Hu Y.,
Lodhi M.,
McCombie W.R.,
Ma H.;
"The Arabidopsis SKP1-LIKE1 gene is essential for male meiosis and may control homologue separation.";
Proc. Natl. Acad. Sci. U.S.A. 96:11416-11421(1999).
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[10]
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FUNCTION.
PubMed=11526079 [NCBI, ExPASy, EBI, Israel, Japan]
Zhao D.,
Yu Q.,
Chen M.,
Ma H.;
"The ASK1 gene regulates B function gene expression in cooperation with UFO and LEAFY in Arabidopsis.";
Development 128:2735-2746(2001).
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[11]
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SUBCELLULAR LOCATION, AND INTERACTION WITH SKIP1; SKIP2; SKIP3; SKIP4; SKIP6; FIB1; CUL1; PAD1; KIN10 AND KIN11.
DOI=10.1093/emboj/20.11.2742; PubMed=11387208 [NCBI, ExPASy, EBI, Israel, Japan]
Farras R.,
Ferrando A.,
Jasik J.,
Kleinow T.,
Oekresz L.,
Tiburcio A.,
Salchert K.,
del Pozo C.,
Schell J.,
Koncz C.;
"SKP1-SnRK protein kinase interactions mediate proteasomal binding of a plant SCF ubiquitin ligase.";
EMBO J. 20:2742-2756(2001).
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[12]
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INTERACTION WITH EID1.
DOI=10.1101/gad.197201; PubMed=11316788 [NCBI, ExPASy, EBI, Israel, Japan]
Dieterle M.,
Zhou Y.-C.,
Schaefer E.,
Funk M.,
Kretsch T.;
"EID1, an F-box protein involved in phytochrome A-specific light signaling.";
Genes Dev. 15:939-944(2001).
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[13]
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INTERACTION WITH ORE9.
DOI=10.1105/tpc.13.8.1779; PubMed=11487692 [NCBI, ExPASy, EBI, Israel, Japan]
Woo H.R.,
Chung K.M.,
Park J.-H.,
Oh S.A.,
Ahn T.,
Hong S.H.,
Jang S.K.,
Nam H.G.;
"ORE9, an F-box protein that regulates leaf senescence in Arabidopsis.";
Plant Cell 13:1779-1790(2001).
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[14]
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IDENTIFICATION IN A SCF COMPLEX.
DOI=10.1074/jbc.M204254200; PubMed=12381738 [NCBI, ExPASy, EBI, Israel, Japan]
Lechner E.,
Xie D.,
Grava S.,
Pigaglio E.,
Planchais S.,
Murray J.A.H.,
Parmentier Y.,
Mutterer J.,
Dubreucq B.,
Shen W.-H.,
Genschik P.;
"The AtRbx1 protein is part of plant SCF complexes, and its down-regulation causes severe growth and developmental defects.";
J. Biol. Chem. 277:50069-50080(2002).
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[15]
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INTERACTION WITH COI1, AND IDENTIFICATION IN A SCF(COI1) COMPLEX.
DOI=10.1105/tpc.003368; PubMed=12172031 [NCBI, ExPASy, EBI, Israel, Japan]
Xu L.,
Liu F.,
Lechner E.,
Genschik P.,
Crosby W.L.,
Ma H.,
Peng W.,
Huang D.,
Xie D.;
"The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis.";
Plant Cell 14:1919-1935(2002).
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[16]
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INTERACTION WITH COI1, AND IDENTIFICATION IN A SCF(COI1) COMPLEX.
DOI=10.1046/j.1365-313X.2002.01432.x; PubMed=12445118 [NCBI, ExPASy, EBI, Israel, Japan]
Devoto A.,
Nieto-Rostro M.,
Xie D.,
Ellis C.,
Harmston R.,
Patrick E.,
Davis J.,
Sherratt L.,
Coleman M.,
Turner J.G.;
"COI1 links jasmonate signalling and fertility to the SCF ubiquitin-ligase complex in Arabidopsis.";
Plant J. 32:457-466(2002).
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[17]
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INTERACTION WITH EBF1 AND EBF2.
DOI=10.1016/S0092-8674(03)00969-3; PubMed=14675532 [NCBI, ExPASy, EBI, Israel, Japan]
Guo H.,
Ecker J.R.;
"Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor.";
Cell 115:667-677(2003).
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[18]
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INTERACTION WITH AFR.
DOI=10.1016/j.cub.2003.11.019; PubMed=14653999 [NCBI, ExPASy, EBI, Israel, Japan]
Harmon F.G.,
Kay S.A.;
"The F box protein AFR is a positive regulator of phytochrome A-mediated light signaling.";
Curr. Biol. 13:2091-2096(2003).
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[19]
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INTERACTION WITH UFO.
DOI=10.1073/pnas.1033043100; PubMed=12826617 [NCBI, ExPASy, EBI, Israel, Japan]
Durfee T.,
Roe J.L.,
Sessions R.A.,
Inouye C.,
Serikawa K.,
Feldmann K.A.,
Weigel D.,
Zambryski P.C.;
"The F-box-containing protein UFO and AGAMOUS participate in antagonistic pathways governing early petal development in Arabidopsis.";
Proc. Natl. Acad. Sci. U.S.A. 100:8571-8576(2003).
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[20]
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FUNCTION, AND TISSUE SPECIFICITY.
DOI=10.1104/pp.103.024703; PubMed=12970487 [NCBI, ExPASy, EBI, Israel, Japan]
Zhao D.,
Ni W.,
Feng B.,
Han T.,
Petrasek M.G.,
Ma H.;
"Members of the Arabidopsis-SKP1-like gene family exhibit a variety of expression patterns and may play diverse roles in Arabidopsis.";
Plant Physiol. 133:203-217(2003).
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[21]
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INTERACTION WITH ADO1; ADO2 AND ADO3.
DOI=10.1093/jxb/erh226; PubMed=15310821 [NCBI, ExPASy, EBI, Israel, Japan]
Yasuhara M.,
Mitsui S.,
Hirano H.,
Takanabe R.,
Tokioka Y.,
Ihara N.,
Komatsu A.,
Seki M.,
Shinozaki K.,
Kiyosue T.;
"Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis.";
J. Exp. Bot. 55:2015-2027(2004).
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[22]
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FUNCTION, AND TISSUE SPECIFICITY.
DOI=10.1105/tpc.017772; PubMed=14688296 [NCBI, ExPASy, EBI, Israel, Japan]
Liu F.,
Ni W.,
Griffith M.E.,
Huang Z.,
Chang C.,
Peng W.,
Ma H.,
Xie D.;
"The ASK1 and ASK2 genes are essential for Arabidopsis early development.";
Plant Cell 16:5-20(2004).
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[23]
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INTERACTION WITH ADO1.
DOI=10.1111/j.1365-313X.2004.02207.x; PubMed=15447654 [NCBI, ExPASy, EBI, Israel, Japan]
Han L.,
Mason M.,
Risseeuw E.P.,
Crosby W.L.,
Somers D.E.;
"Formation of an SCF(ZTL) complex is required for proper regulation of circadian timing.";
Plant J. 40:291-301(2004).
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- FUNCTION: Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends of the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1. SCF(UFO) is required for vegetative and floral organ development as well as for male gametogenesis. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1), SCF(ADO2), SCF(ADO3) are related to the circadian clock. SCF(ORE9) seems to be involved in senescence. SCF(EBF1/EBF2) may regulate ethylene signaling. Plays a role during embryogenesis and early postembryonic development, especially during cell elongation and division. Contributes to the correct chromosome segregation during tetrad formation.
- PATHWAY: Protein degradation; protein ubiquitination.
- SUBUNIT: Part of a SCF E3 ubiquitin ligase complex composed of SKP1, CUL1, RBX1 (RBX1A or RBX1B) and F-box proteins such as UFO, EID1, AFR, ORE9, ADO1/ZTL, ADO2/LKP2, ADO3/FKF1, EBF1, EBF2, COI1 and TIR1. The SKP1A subunit of the SCF E3 ubiquitin ligase complex can interact directly with KIN10, KIN11 and the proteasome subunit PAD1. This interaction can be disrupted by PRL1. Also interacts with SKIP1, SKIP2, SKIP3, SKIP4, SKIP6 and FIB1/SKIP7.
- INTERACTION:
Q65967:- (xeno); NbExp=1; IntAct=EBI-532357, EBI-848577;
Q9LU91:-; NbExp=2; IntAct=EBI-532357, EBI-604313;
Q94BT6:ADO1; NbExp=4; IntAct=EBI-532357, EBI-300691;
Q8LAW2:AFR; NbExp=3; IntAct=EBI-532357, EBI-604438;
Q9ZU90:At2g01620/T8O11.21; NbExp=2; IntAct=EBI-532357, EBI-604427;
O04197:COI1; NbExp=6; IntAct=EBI-532357, EBI-401159;
Q94AH6:CUL1; NbExp=3; IntAct=EBI-532357, EBI-532411;
Q9SKK0:EBF1; NbExp=3; IntAct=EBI-532357, EBI-401198;
Q8LEA8:EID1; NbExp=2; IntAct=EBI-532357, EBI-687388;
Q9XI00:FBP7; NbExp=2; IntAct=EBI-532357, EBI-591127;
O49279:FBX3; NbExp=2; IntAct=EBI-532357, EBI-591174;
Q38825:IAA7; NbExp=2; IntAct=EBI-532357, EBI-602959;
Q9LEX0:PP2A13; NbExp=3; IntAct=EBI-532357, EBI-604261;
Q9FJ80:PP2A14; NbExp=2; IntAct=EBI-532357, EBI-604303;
Q9FDX1:SKIP1; NbExp=2; IntAct=EBI-532357, EBI-604228;
Q570C0:TIR1; NbExp=4; IntAct=EBI-532357, EBI-307183;
Q39090:UFO; NbExp=4; IntAct=EBI-532357, EBI-590758;
P15597:virF (xeno); NbExp=5; IntAct=EBI-532357, EBI-605118;
- SUBCELLULAR LOCATION: Nucleus. Spindle. Cytoplasm, cytoskeleton, phragmoplast. Note=Associated to mitotic spindle and phragmoplasts during cell division.
- TISSUE SPECIFICITY: Accumulates only in meristematic cells. Expressed in inflorescence, shoot and root apical meristems, as well as in developing organs such as gametocytes and seeds. Also detected in cortical layer and epidermis of roots, leaves, pith and vascular bundle of young stem, young floral buds and organ primordia, pollen and through the valve of siliques. Not detectable in mature root tissues.
- DEVELOPMENTAL STAGE: During flower development, expressed in the tapetal layer surrounding the male microsporocytes, and in the endothelium layer surrounding the embryo sac within the ovule. During embryogenesis, expressed in all cells of the embryo and in developing endosperm surrounding the embryo, at the time of free nuclei proliferation.
- SIMILARITY: Belongs to the SKP1 family.
- WEB RESOURCE: Name=PlantsUBQ; Note=A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants; URL="http://plantsubq.genomics.purdue.edu/";.
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