ID   IAA7_ARATH              Reviewed;         243 AA.
AC   Q38825; Q8LAK1;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   22-JUL-2008, entry version 70.
DE   RecName: Full=Auxin-responsive protein IAA7;
DE   AltName: Full=Indoleacetic acid-induced protein 7;
DE   AltName: Full=Auxin resistant 2;
GN   Name=IAA7; Synonyms=AXR2; OrderedLocusNames=At3g23050;
GN   ORFNames=MXC7.8;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   STRAIN=cv. Columbia;
RX   MEDLINE=95387393; PubMed=7658471; DOI=10.1006/jmbi.1995.0454;
RA   Abel S., Nguyen M.D., Theologis A.;
RT   "The PS-IAA4/5-like family of early auxin-inducible mRNAs in
RT   Arabidopsis thaliana.";
RL   J. Mol. Biol. 251:533-549(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   MEDLINE=20277480; PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   MEDLINE=22954850; PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA   Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA   Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA   Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA   Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA   Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA   Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA   Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA   Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA   Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA   Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA   Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   MUTANT AXR2-1.
RX   PubMed=10859186; DOI=10.1104/pp.123.2.563;
RA   Nagpal P., Walker L.M., Young J.C., Sonawala A., Timpte C.,
RA   Estelle M., Reed J.W.;
RT   "AXR2 encodes a member of the Aux/IAA protein family.";
RL   Plant Physiol. 123:563-574(2000).
RN   [6]
RP   GENE FAMILY, NOMENCLATURE, AND FUNCTION.
RX   MEDLINE=22031748; PubMed=12036262; DOI=10.1023/A:1015255030047;
RA   Liscum E., Reed J.W.;
RT   "Genetics of Aux/IAA and ARF action in plant growth and development.";
RL   Plant Mol. Biol. 49:387-400(2002).
RN   [7]
RP   TRANSCRIPTIONAL REPRESSION DOMAIN.
RX   PubMed=14742873; DOI=10.1105/tpc.017384;
RA   Tiwari S.B., Hagen G., Guilfoyle T.J.;
RT   "Aux/IAA proteins contain a potent transcriptional repression
RT   domain.";
RL   Plant Cell 16:533-543(2004).
CC   -!- FUNCTION: Aux/IAA proteins are short-lived transcriptional factors
CC       that function as repressor of early auxin response genes at low
CC       auxin concentrations. Repression is thought to result from the
CC       interaction with auxin response factors (ARFs), proteins that bind
CC       to the auxin-responsive promoter element (AuxRE). Formation of
CC       heterodimers with ARF proteins may alter their ability to modulate
CC       early auxin response genes expression.
CC   -!- SUBUNIT: Homo and heterodimers (By similarity).
CC   -!- INTERACTION:
CC       Q9LW29:AFB2; NbExp=1; IntAct=EBI-602959, EBI-617556;
CC       Q9LPW7:AFB3; NbExp=1; IntAct=EBI-602959, EBI-617501;
CC       Q94AH6:CUL1; NbExp=3; IntAct=EBI-602959, EBI-532411;
CC       Q9ZR12:GRH1; NbExp=1; IntAct=EBI-602959, EBI-617479;
CC       Q39255:SKP1A; NbExp=2; IntAct=EBI-602959, EBI-532357;
CC       Q570C0:TIR1; NbExp=3; IntAct=EBI-602959, EBI-307183;
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences;
CC       Name=1;
CC         IsoId=Q38825-1; Sequence=Displayed;
CC   -!- TISSUE SPECIFICITY: Highly expressed in stems and flowers.
CC   -!- INDUCTION: By auxin.
CC   -!- DOMAIN: The N-terminal half of the protein contains two conserved
CC       domains I and II. Domain I includes a slightly degenerated ERF-
CC       associated amphiphilic repression (EAR) motif which seems to be
CC       involved in the activity of transcriptional repression. Domain II
CC       is required for the correct degradation of the protein through the
CC       SCF-mediated ubiquitin-proteasome pathway. Interactions between
CC       Aux/IAA proteins and auxin response factors (ARFs) occur through
CC       their C-terminal dimerization domains III and IV.
CC   -!- SIMILARITY: Belongs to the Aux/IAA family.
CC   -!- SIMILARITY: Contains 1 Aux/IAA-ARF domain.
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DR   EMBL; U18409; AAC49048.1; -; mRNA.
DR   EMBL; AB026655; BAB02096.1; -; Genomic_DNA.
DR   EMBL; AF332395; AAG48759.1; -; mRNA.
DR   EMBL; AY054651; AAK96842.1; -; mRNA.
DR   EMBL; AY072461; AAL66876.1; -; mRNA.
DR   EMBL; AY087765; AAM65301.1; ALT_INIT; mRNA.
DR   PIR; S58494; S58494.
DR   RefSeq; NP_188945.1; -.
DR   UniGene; At.22260; -.
DR   IntAct; Q38825; -.
DR   GeneID; 821879; -.
DR   GenomeReviews; BA000014_GR; AT3G23050.
DR   KEGG; ath:AT3G23050; -.
DR   NMPDR; fig|3702.1.peg.14555; -.
DR   GeneFarm; 3154; 342.
DR   TAIR; At3g23050; -.
DR   ArrayExpress; Q38825; -.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   InterPro; IPR003311; AUX_IAA.
DR   InterPro; IPR011525; AuxIAA_ARF_dimer.
DR   Pfam; PF02309; AUX_IAA; 1.
DR   PROSITE; PS50962; IAA_ARF; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Auxin signaling pathway; Complete proteome;
KW   Nucleus; Repressor; Transcription; Transcription regulation.
FT   CHAIN         1    243       Auxin-responsive protein IAA7.
FT                                /FTId=PRO_0000112838.
FT   DOMAIN      125    225       Aux/IAA-ARF.
FT   MOTIF        13     17       EAR-like (transcriptional repression).
FT   MUTAGEN      87     87       P->S: In axr2-1; gain of function.
FT                                Affects auxin-related developmental
FT                                processes. Affects photomorphogenesis.
FT   CONFLICT    228    228       V -> I (in Ref. 4; AAM65301).
SQ   SEQUENCE   243 AA;  26381 MW;  830E9B9EA2C2B5D0 CRC64;
     MIGQLMNLKA TELCLGLPGG AEAVESPAKS AVGSKRGFSE TVDLMLNLQS NKEGSVDLKN
     VSAVPKEKTT LKDPSKPPAK AQVVGWPPVR NYRKNMMTQQ KTSSGAEEAS SEKAGNFGGG
     AAGAGLVKVS MDGAPYLRKV DLKMYKSYQD LSDALAKMFS SFTMGNYGAQ GMIDFMNESK
     LMNLLNSSEY VPSYEDKDGD WMLVGDVPWE MFVESCKRLR IMKGSEAVGL APRAMEKYCK
     NRS
//