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UniProtKB/TrEMBL entry Q2M4J6


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name Q2M4J6_MOUSE
Primary accession number Q2M4J6
Secondary accession numbers None
Integrated into TrEMBL on February 21, 2006
Sequence was last modified on February 21, 2006 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 30)
Name and origin of the protein
Protein name Interleukin 1 beta
Synonyms None
Gene name
Name: Il1b
ORFNames: RP23-384K11.2-001, mCG_20999
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE.
STRAIN=CAST/EiJ;
TISSUE=Spleen;
Farber C.R., Corva P.M., Medrano J.F.;
"Characterization of quantitative trait loci influencing growth and adiposity using congenic mouse strains.";
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE.
Sycamore N.;
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE.
STRAIN=Mixed;
DOI=10.1126/science.1069193; PubMed=12040188 [NCBI, ExPASy, EBI, Israel, Japan]
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.;
"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.";
Science 296:1661-1671(2002).
[4]
NUCLEOTIDE SEQUENCE.
STRAIN=Mixed;
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Comments
  • FUNCTION: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).
  • SUBUNIT: Monomer (By similarity).
  • SIMILARITY: Belongs to the IL-1 family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY902319; AAX90604.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL808143; CAM22719.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH466519; EDL28238.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00114067; -.
RefSeq NP_032387.1; -.
UniGene Mm.222830
3D structure databases
ModBase Q2M4J6.
Organism-specific databases
MGI MGI:96543; Il1b.
Gene expression databases
ArrayExpress Q2M4J6; -.
Bgee Q2M4J6; -.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (inferred from direct assay from MGI).
GO:0031982; Cellular component: vesicle (inferred from direct assay from MGI).
GO:0005125; Molecular function: cytokine activity (inferred from direct assay from MGI).
GO:0005149; Molecular function: interleukin-1 receptor binding (inferred from electronic annotation from InterPro).
GO:0000187; Biological process: activation of MAPK activity (inferred from electronic annotation from Compara).
GO:0001525; Biological process: angiogenesis (inferred from electronic annotation from Compara).
GO:0006916; Biological process: anti-apoptosis (inferred from electronic annotation from Compara).
GO:0019221; Biological process: cytokine-mediated signaling pathway (inferred from electronic annotation from Compara).
GO:0007204; Biological process: elevation of cytosolic calcium ion concentration (inferred from electronic annotation from Compara).
GO:0006955; Biological process: immune response (inferred from electronic annotation from InterPro).
GO:0006954; Biological process: inflammatory response (inferred from electronic annotation from InterPro).
GO:0030593; Biological process: neutrophil chemotaxis (inferred from direct assay from MGI).
GO:0045080; Biological process: positive regulation of chemokine biosynthetic process (inferred from direct assay from MGI).
GO:0043123; Biological process: positive regulation of I-kappaB kinase/NF-kappaB cascade (inferred from direct assay from MGI).
GO:0045410; Biological process: positive regulation of interleukin-6 biosynthetic process (inferred from direct assay from MGI).
GO:0032755; Biological process: positive regulation of interleukin-6 production (inferred from direct assay from MGI).
GO:0046330; Biological process: positive regulation of JNK cascade (inferred from direct assay from MGI).
GO:0045429; Biological process: positive regulation of nitric oxide biosynthetic process (inferred from electronic annotation from Compara).
GO:0001934; Biological process: positive regulation of protein amino acid phosphorylation (inferred from electronic annotation from Compara).
GO:0051091; Biological process: positive regulation of transcription factor activity (inferred from electronic annotation from Compara).
GO:0050796; Biological process: regulation of insulin secretion (inferred from electronic annotation from Compara).
GO:0033198; Biological process: response to ATP (inferred from direct assay from MGI).
GO:0032496; Biological process: response to lipopolysaccharide (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR002348; IL1_HBGF.
IPR003502; IL1_propep.
IPR000975; Interleukin_1.
IPR003294; InterleukinIL1AB.
IPR003296; InterleukinIL1B.
Graphical view of domain structure.
Pfam PF00340; IL1; 1.
PF02394; IL1_propep; 1.
Pfam graphical view of domain structure.
PRINTS PR00262; IL1HBGF.
PR00264; INTERLEUKIN1.
PR01359; INTRLEUKIN1B.
PR01357; INTRLEUKN1AB.
ProDom PD002536; Interleukin_1; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00125; IL1; 1.
SMART graphical view of domain structure.
PROSITE PS00253; INTERLEUKIN_1; 1.
Genome annotation databases
Ensembl ENSMUSG00000027398; Mus musculus. [Contig view]
GeneID 16176; -.
KEGG mmu:16176; -.
Phylogenomic databases
HOVERGEN Q2M4J6; -.
OMA Q2M4J6; LYLSCVM.
Other
NextBio 289037; -.
SOURCE Il1b; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytokine; Inflammatory response; Mitogen; Pyrogen.
Features
None
Sequence information
Length: 269 AA Molecular weight: 30931 Da CRC64: 734FA17B02ED87EE [This is a checksum on the sequence]
        10         20         30         40         50         60 
MATVPELNCE MPPFDSDEND LFFEVDGPQK MKGCFQTFDL GCPDESIQLQ ISQQHINKSF 

        70         80         90        100        110        120 
RQAVSLIVAV EKLWQLPVSF PWTFQDEDMS TFFSFIFEEE PILCDSWDDD DNLLVCDVPI 

       130        140        150        160        170        180 
RQLHYRLRDE QQKSLVLSDP YELKALHLNG QNINQQVIFS MSFVQGEPSN DKIPVALGLK 

       190        200        210        220        230        240 
GKNLYLSCVM KDGTPTLQLE SVDPKQYPKK KMEKRFVFNK IEVKSKVEFE SAEFPNWYIS 

       250        260 
TSQAEHKPVF LGNNSGQDII DFTMESVSS 

Q2M4J6 in FASTA format

View entry in raw text format (no links)
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