[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=Hereford; TISSUE=Hypothalamus; NIH - Mammalian Gene Collection (MGC) project; Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Hydrolyzes ITP and dITP to their respective monophosphate derivatives. Xanthosine 5'-triphosphate (XTP) is also a potential substrate. May be the major enzyme responsible for regulating ITP concentration in cells (By similarity).
CATALYTIC ACTIVITY: A nucleoside triphosphate + H₂O = a nucleotide + diphosphate.
COFACTOR: Binds 1 magnesium ion per subunit (By similarity).
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the HAM1 NTPase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC112688; AAI12689.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001069750.1; -.

UniGene

Bt.53005

3D structure databases

SMR

Q2KIC5; 1-192.

ModBase

Q2KIC5.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0000287;	Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0047429;	Molecular function: nucleoside-triphosphate diphosphatase activity (inferred from electronic annotation from EC).
GO:0009117;	Biological process: nucleotide metabolic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002637; Ham1p_like.
Graphical view of domain structure.

PANTHER

PTHR11067; Ham1p_like; 1.

Pfam

PF01725; Ham1p_like; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00042; Ham1p_like; 1.

ProtoNet

Q2KIC5.

Genome annotation databases

Ensembl

ENSBTAG00000013776; Bos taurus. [Contig view]

GeneID

613653; -.

KEGG

bta:613653; -.

Phylogenomic databases

HOVERGEN

Q2KIC5; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Hydrolase; Magnesium; Metal-binding; Nucleotide metabolism.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 208`	`208`	`Inosine triphosphate pyrophosphatase.`	`PRO_0000306869`
`METAL`	`44 44`		`Magnesium (By similarity).`

Sequence information

Length: 208 AA [This is the length of the unprocessed precursor]

Molecular weight: 23061 Da [This is the MW of the unprocessed precursor]

CRC64: F49F922F60A8822B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAASLAGKKI VFVTGNAKKL EEVIQILGDK FPCTLVAQKI DLPEYQGEPD EISIRKCQEA 

        70         80         90        100        110        120 
ARQVQGPVLV EDTCLCFNAL GGLPGPYIKW FLEKLKPEGL HQLLEGFQDK SAYALCTFAF 

       130        140        150        160        170        180 
STGDPNEPVR LFRGRTMGRI VVPRGCRDFG WDPCFQPDGY EQTYAEMPKA EKNTISHRFR 

       190        200 
ALLALQEYFS SLTPGVGDDH PSWGSGEG

Q2KIC5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools