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UniProtKB/Swiss-Prot entry Q2KCC6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FOLD1_RHIEC
Primary accession number Q2KCC6
Secondary accession numbers None
Integrated into Swiss-Prot on December 12, 2006
Sequence was last modified on March 7, 2006 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 20)
Name and origin of the protein
Protein name Bifunctional protein folD 1
Synonyms None
Includes Methylenetetrahydrofolate dehydrogenase
     (EC 1.5.1.5)
Methenyltetrahydrofolate cyclohydrolase
     (EC 3.5.4.9)
Gene name
Name: folD1
OrderedLocusNames: RHE_CH00694
From
Rhizobium etli (strain CFN 42 / ATCC 51251) [TaxID: 347834] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0508502103; PubMed=16505379 [NCBI, ExPASy, EBI, Israel, Japan]
Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I., Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A., Jimenez-Jacinto V., Collado-Vides J., Davila G.;
"The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons.";
Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000133; ABC89510.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_468237.1; -.
3D structure databases
ModBase Q2KCC6.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004477; Molecular function: methenyltetrahydrofolate cyclohydrolase activity (inferred from electronic annotation from HAMAP).
GO:0004488; Molecular function: methylenetetrahydrofolate dehydrogenase (NADP+) activity (inferred from electronic annotation from HAMAP).
GO:0009396; Biological process: folic acid and derivative biosynthetic process (inferred from electronic annotation from InterPro).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0009086; Biological process: methionine biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0006730; Biological process: one-carbon compound metabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006164; Biological process: purine nucleotide biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01576; -; 1.
PBIL [Tree]
InterPro IPR016040; NAD(P)-bd.
IPR000672; THF_DHase/CycOHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00763; THF_DHG_CYH; 1.
PF02882; THF_DHG_CYH_C; 1.
Pfam graphical view of domain structure.
PRINTS PR00085; THFDHDRGNASE.
ProDom PD002300; THFDhg/Cyc_hydro; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00766; THF_DHG_CYH_1; FALSE_NEG.
PS00767; THF_DHG_CYH_2; 1.
ProtoNet Q2KCC6.
Genome annotation databases
GeneID 3891245; -.
GenomeReviews CP000133_GR; RHE_CH00694.
KEGG ret:RHE_CH00694; -.
Phylogenomic databases
HOGENOM Q2KCC6; -.
Genome annotation databases
CMR Q2KCC6; RHE_CH00694.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Hydrolase; Methionine biosynthesis; Multifunctional enzyme; NADP; One-carbon metabolism; Oxidoreductase; Purine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   299  299     Bifunctional protein folD 1. PRO_0000268459
Sequence information
Length: 299 AA [This is the length of the unprocessed precursor] Molecular weight: 30838 Da [This is the MW of the unprocessed precursor] CRC64: BABADA364BB694BA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MATVIDGKNV AASVIQTVKS ATAALEKASG VTTGLAVIIV GDDPASHAYV GSKSRMAKEC 

        70         80         90        100        110        120 
GFKSVQHTLP AETTQEELAG LVATLNADPS IHGILVQLPL PKPLDSEPII QSILPEKDVD 

       130        140        150        160        170        180 
GLSVVNAGKL ATGDLKTGLV SCTPAGAMVF VRRTHGEDLS GLNAVVIGRS NLFGKPMAQL 

       190        200        210        220        230        240 
LLNANATVTI AHSRTKNLAE VCRNADILVA AVGRPEMVKA DWVKPGATVI DVGINRVPAP 

       250        260        270        280        290 
EKGEGKTRLV GDVAFREVSE IASTITPVPG GVGPMTIAML MANTVIAAHR AAGQTPPQF
Q2KCC6 in FASTA format

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