ID   DNAE2_RHOP2             Reviewed;        1165 AA.
AC   Q2IU52;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-NOV-2008, entry version 23.
DE   RecName: Full=Error-prone DNA polymerase;
DE            EC=2.7.7.7;
GN   Name=dnaE2; OrderedLocusNames=RPB_3563;
OS   Rhodopseudomonas palustris (strain HaA2).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=316058;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Pelletier D.A.,
RA   Kyrpides N., Anderson I., Oda Y., Harwood C.S., Richardson P.;
RT   "Complete sequence of Rhodopseudomonas palustris HaA2.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis
CC       and translesion synthesis (TLS). It is not the major replicative
CC       DNA polymerase (By similarity).
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily.
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DR   EMBL; CP000250; ABD08258.1; -; Genomic_DNA.
DR   RefSeq; YP_487169.1; -.
DR   GeneID; 3911365; -.
DR   GenomeReviews; CP000250_GR; RPB_3563.
DR   KEGG; rpb:RPB_3563; -.
DR   HOGENOM; Q2IU52; -.
DR   BioCyc; RPAL316058:RPB_3563-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:HAMAP.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:HAMAP.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0045020; P:error-prone DNA repair; IEA:HAMAP.
DR   HAMAP; MF_01902; -; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha.
DR   InterPro; IPR004365; NA_bd_OB_tRNA-helicase.
DR   InterPro; IPR004013; PHP_C.
DR   InterPro; IPR003141; PHP_N.
DR   InterPro; IPR004805; PolC_alpha.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
FT   CHAIN         1   1165       Error-prone DNA polymerase.
FT                                /FTId=PRO_1000070595.
SQ   SEQUENCE   1165 AA;  129923 MW;  8CE6E61C64440D16 CRC64;
     MNAPRYAEIG VTTNFSFLEG GSHPQDYVHQ ASRLGLDAIG IADRNTLAGV VRAYSELDNE
     ELAYKPKLLI GARLCFVDGT PDVLAYPTDR AAYGRLCRLL SAGKLRAGKG ECHLTFADLE
     AFVSSNAARP FPSSWPGLTR PSTSLQPRVL QDVDARDKPG HDGGKREIGR SQILFVLMPP
     YRFQAKAITA ALERLTALNS GNVWLALAPY YRGDDKRRLA RLRRIAAAAD VPGIATNDVL
     YHHPSRRALQ DVLTCVRDKT TIDKAGRRLE GNAERHLKPA AEMARLFRAD LDAVAETLRF
     ADRISFTLDE LKYHYPDEPV PPGKTAQQHL EDLTREGIAT YFPNGISDRL RATIAKELTL
     IAKRDYAHYF LTVHDIVRYA RSQNILCQGR GSAANSAVCY VLGITCVDPT EIDLLFERFV
     SEERDEPPDI DVDFEHSRRE EVMQYIYRRY GRHRAAIVST VIHYRPRSAI RDVGKALGLS
     EDVTAALADT VWGSWGKGLS EMQVRQAGLD PTNPMIGRAV ELATELIGFP RHLSQHVGGY
     VLTQDRLDSY VPIGNAAMAD RTFIEWDKDD IDAVKMMKVD VLALGMLTCI RKGFDLIAQH
     KGVRFQLSDI KSEDDNNVYQ MLQRGESIGV FQVESRAQMN MLPRLKPRCF YDLVIEVAIV
     RPGPIQGDMV HPYLRRRNGQ EPVVYPSPSG EAGDKNELQQ ILGKTLGVPL FQEQAMRIAI
     EAAHFTPDEA NQLRRAMATF RNVGTIGKFE SKMIGNLMAR GYDATFAKNC FEQIKGFGSY
     GFPESHAASF AKLVYVSAWM KCEHPDAFCC ALLNSQPMGF YAPAQIVGDA RANKVEVRPV
     DVSFSDGQCT LEERCGAYHA VRLGFRQIDG FRWADPDEER VRLEAGLPPS DDWAARIVAA
     RARGPFGSLE QFARITALPK RALILLADAD AFRSLGLDRR AALWAVRRLP DDVPLPLFEA
     ASAREQQDEQ AAPLPQMPMA EHVVADYQTV RLSLKGHPLE FLRAVFATER VVTCREVSET
     RRNGRRVRCA GVVLVRQRPG SASGVIFMTI EDETGIANIV VWPSVMEKFR KEVMGARLIL
     VEGKIQASPE GVVHLVAERL VDRSSEMGRL SEGLARPPLP TGADLYEPLT YEPLNGDRRD
     NPDAPAQRLR HPRDVRILPP SRDFH
//