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UniProtKB/Swiss-Prot entry Q2IK16

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDH2_ANADE
Primary accession number Q2IK16
Secondary accession numbers None
Integrated into Swiss-Prot on June 27, 2006
Sequence was last modified on March 7, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 22)
Name and origin of the protein
Protein name Malate dehydrogenase 2
Synonym EC 1.1.1.37
Gene name
Name: mdh2
OrderedLocusNames: Adeh_2226
From
Anaeromyxobacter dehalogenans (strain 2CP-C) [TaxID: 290397] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales; Cystobacterineae; Myxococcaceae; Anaeromyxobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M., Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000251; ABC81996.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_465433.1; -.
3D structure databases
ModBase Q2IK16.
Enzyme and pathway databases
BioCyc ADEH290397:ADEH_2226-MON; -.
Ontologies
GO
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00487; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR011275; Malate_DHase_NAD-dep_bac.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01763; MalateDH_bact; 1.
BLOCKS Q2IK16.
Genome annotation databases
GeneID 3889615; -.
GenomeReviews CP000251_GR; Adeh_2226.
KEGG ade:Adeh_2226; -.
Phylogenomic databases
HOGENOM Q2IK16; -.
Genome annotation databases
CMR Q2IK16; Adeh_2226.
Other
ProtoNet Q2IK16.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   316  316     Malate dehydrogenase 2. PRO_0000241940
NP_BIND   10    15  6     NAD (By similarity). 
NP_BIND   119   121  3     NAD (By similarity). 
ACT_SITE   176   176        Proton acceptor (By similarity). 
BINDING   34    34        NAD (By similarity). 
BINDING   83    83        Substrate (By similarity). 
BINDING   89    89        Substrate (By similarity). 
BINDING   96    96        NAD (By similarity). 
BINDING   121   121        Substrate (By similarity). 
BINDING   152   152        Substrate (By similarity). 
Sequence information
Length: 316 AA [This is the length of the unprocessed precursor] Molecular weight: 33020 Da [This is the MW of the unprocessed precursor] CRC64: 5DFE384EA886C555 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MARSKIALIG GGQIGGVLAQ LAALRELGDV VLFDIVEGLP QGKTLDIAEA APVDGFDVSL 

        70         80         90        100        110        120 
KGTNTYEDIK GADVVIVTAG LPRKPGMSRD DLIAVNSKIM TTVAEGIKQY APNAFVIVIS 

       130        140        150        160        170        180 
NPLDAMVTLC QRITGFPHNR VVGQAGVLDS ARFAAFIAWE LGVSVKDVTA VTLGGHGDDM 

       190        200        210        220        230        240 
VPLVRYTSVC GVPVMELLEQ KYGAAKAAEV MAAMVKRTRG AGGEVVALLK TGSAFYSPAS 

       250        260        270        280        290        300 
SAIAMAESFL KDQKRVLPTC AFLKGEFGVD GLYVGVPVVI GAGGAERVLQ LKLNAEEQAM 

       310 
MDKSVKAVKD LVATLK
Q2IK16 in FASTA format

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