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UniProtKB/Swiss-Prot entry Q2IJK7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LEU3_ANADE
Primary accession number Q2IJK7
Secondary accession numbers None
Integrated into Swiss-Prot on September 19, 2006
Sequence was last modified on March 7, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 23)
Name and origin of the protein
Protein name 3-isopropylmalate dehydrogenase
Synonyms EC 1.1.1.85
Beta-IPM dehydrogenase
IMDH
3-IPM-DH
Gene name
Name: leuB
OrderedLocusNames: Adeh_2070
From
Anaeromyxobacter dehalogenans (strain 2CP-C) [TaxID: 290397] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales; Cystobacterineae; Myxococcaceae; Anaeromyxobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M., Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000251; ABC81840.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_465277.1; -.
3D structure databases
ModBase Q2IJK7.
Enzyme and pathway databases
BioCyc ADEH290397:ADEH_2070-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003862; Molecular function: 3-isopropylmalate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009098; Biological process: leucine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01033; -; 1.
PBIL [Tree]
InterPro IPR004429; 3-isopropylmalate_DHase.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF13; IPMDH; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00169; leuB; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q2IJK7.
Genome annotation databases
GeneID 3888347; -.
GenomeReviews CP000251_GR; Adeh_2070.
KEGG ade:Adeh_2070; -.
Phylogenomic databases
HOGENOM Q2IJK7; -.
Genome annotation databases
CMR Q2IJK7; Adeh_2070.
Other
ProtoNet Q2IJK7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Leucine biosynthesis; Magnesium; Manganese; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   353  353     3-isopropylmalate dehydrogenase. PRO_0000250101
NP_BIND   76    89  14     NAD (By similarity). 
NP_BIND   281   293  13     NAD (By similarity). 
METAL   223   223        Magnesium or manganese (By similarity). 
METAL   247   247        Magnesium or manganese (By similarity). 
METAL   251   251        Magnesium or manganese (By similarity). 
BINDING   96    96        Substrate (By similarity). 
BINDING   106   106        Substrate (By similarity). 
BINDING   134   134        Substrate (By similarity). 
BINDING   223   223        Substrate (By similarity). 
SITE   141   141  1     Important for catalysis (By similarity). 
SITE   191   191  1     Important for catalysis (By similarity). 
Sequence information
Length: 353 AA [This is the length of the unprocessed precursor] Molecular weight: 37286 Da [This is the MW of the unprocessed precursor] CRC64: 088C964A71D5E7B7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNAKIVVLPG DGIGPEVTAE AVRVLEAVAR RGGHALSFTE RLMGGCSIDA HGTALTPEVL 

        70         80         90        100        110        120 
ADCQAADAVL LGAVGGPKWD DPRAKVRPEQ GLLGLRKGLG VFANLRPVRV HPSLLDSSPL 

       130        140        150        160        170        180 
RPEKLRGVDI MVIRELTGGL YFGQPKGRDV KDGHARAVDT LEYQDFEVRR VVELAFRIAK 

       190        200        210        220        230        240 
GRKKKVTSVD KANVLESSRL WRELATAIGQ ANPDVALDHM LVDTAAMRLV TSPATLDVVV 

       250        260        270        280        290        300 
TENMFGDILT DEASVLAGSM GMLPSASIGE QGPGLYEPIH GSAPDIAGKG IANPVGTVLS 

       310        320        330        340        350 
AALLLRHSLG LEPEAAAIER AVDQTITDGC RTADLGGKLS TRAMADEILK RLA
Q2IJK7 in FASTA format

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