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UniProtKB/Swiss-Prot entry Q2IIC2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDH1_ANADE
Primary accession number Q2IIC2
Secondary accession numbers None
Integrated into Swiss-Prot on June 27, 2006
Sequence was last modified on March 7, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 22)
Name and origin of the protein
Protein name Malate dehydrogenase 1
Synonym EC 1.1.1.37
Gene name
Name: mdh1
OrderedLocusNames: Adeh_1626
From
Anaeromyxobacter dehalogenans (strain 2CP-C) [TaxID: 290397] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales; Cystobacterineae; Myxococcaceae; Anaeromyxobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M., Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000251; ABC81399.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_464836.1; -.
3D structure databases
ModBase Q2IIC2.
Enzyme and pathway databases
BioCyc ADEH290397:ADEH_1626-MON; -.
Ontologies
GO
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00487; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR011275; Malate_DHase_NAD-dep_bac.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01763; MalateDH_bact; 1.
BLOCKS Q2IIC2.
Genome annotation databases
GeneID 3888125; -.
GenomeReviews CP000251_GR; Adeh_1626.
KEGG ade:Adeh_1626; -.
Phylogenomic databases
HOGENOM Q2IIC2; -.
Genome annotation databases
CMR Q2IIC2; Adeh_1626.
Other
ProtoNet Q2IIC2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   312  312     Malate dehydrogenase 1. PRO_0000241939
NP_BIND   11    16  6     NAD (By similarity). 
NP_BIND   122   124  3     NAD (By similarity). 
ACT_SITE   179   179        Proton acceptor (By similarity). 
BINDING   35    35        NAD (By similarity). 
BINDING   86    86        Substrate (By similarity). 
BINDING   92    92        Substrate (By similarity). 
BINDING   99    99        NAD (By similarity). 
BINDING   124   124        Substrate (By similarity). 
BINDING   155   155        Substrate (By similarity). 
Sequence information
Length: 312 AA [This is the length of the unprocessed precursor] Molecular weight: 32915 Da [This is the MW of the unprocessed precursor] CRC64: EC486A2D26D3E1CC [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAQRKKIALI GAGQIGGTLA LLAGQKELGD VVLVDIMEGV AKGKALDLQE TRGVGKWDVD 

        70         80         90        100        110        120 
VTGGGTTDYS VIRDADVCIV TAGVPRKPGM SREDLLKVNL DAITKVAHGI KQYAPNAFVI 

       130        140        150        160        170        180 
VITNPLDSMV YAMYKVTGFP KNRVVGMAGV LDTARFQYFV GDAAGVSPQD VQAMVLGGHG 

       190        200        210        220        230        240 
DDMVPLLRYS SVAGVPLTRL LDKAKLDAIV ERTRKGGGEI VALLGTGSAF YAPAASAIAM 

       250        260        270        280        290        300 
AESYLRDKKR VLPCSALLEG QYGVKGLFVG VPVVIGAGGV ERVLELELND DERAMLQRSV 

       310 
DSVKKSVAET KL
Q2IIC2 in FASTA format

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