ID   DNAE2_ANADE             Reviewed;        1132 AA.
AC   Q2IIA8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-NOV-2008, entry version 21.
DE   RecName: Full=Error-prone DNA polymerase;
DE            EC=2.7.7.7;
GN   Name=dnaE2; OrderedLocusNames=Adeh_1612;
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis
CC       and translesion synthesis (TLS). It is not the major replicative
CC       DNA polymerase (By similarity).
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily.
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DR   EMBL; CP000251; ABC81385.1; -; Genomic_DNA.
DR   RefSeq; YP_464822.1; -.
DR   GeneID; 3888111; -.
DR   GenomeReviews; CP000251_GR; Adeh_1612.
DR   KEGG; ade:Adeh_1612; -.
DR   HOGENOM; Q2IIA8; -.
DR   BioCyc; ADEH290397:ADEH_1612-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:HAMAP.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:HAMAP.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0045020; P:error-prone DNA repair; IEA:HAMAP.
DR   HAMAP; MF_01902; -; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha.
DR   InterPro; IPR004365; NA_bd_OB_tRNA-helicase.
DR   InterPro; IPR004013; PHP_C.
DR   InterPro; IPR003141; PHP_N.
DR   InterPro; IPR004805; PolC_alpha.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
FT   CHAIN         1   1132       Error-prone DNA polymerase.
FT                                /FTId=PRO_1000088470.
SQ   SEQUENCE   1132 AA;  121076 MW;  27804FBFF75A32F5 CRC64;
     MSHAPRYAEL RCKSCFSFLE GASHPEELVG RAAELGLSGL ALADVNGLYG IVRAHAEAKR
     QGLPLIVGAE LVVAGLAPGR PARLVLLAQD REGYAGLCRL VTRAHCGEGW TGAPPRRERD
     AVAVPFEAVA AGARGLFALY PGADGDAVAR LKDAFGRRAA LAVARHRVAG EEARVLAARS
     AGRRLGVPVA VTNDVHTHAR ARQVLQDVLT CVRHGTTVDR AGRRLFPNAE RTLKGPEELA
     RLWSDFPEGL AAAADIADQC RFRMEEIRGE HPLPPVVVER GGLAGGVEVA TSSPAQAARD
     GARSTTPSLR LRASLPAEPP AAPAPEAPAA AAAPGLAASA ASVAADTGAD RDGALAGMAL
     LRELVREGAR WRYGGEPPED VARQLARELD LVESLGYASY FLTVWDVVRF ARSRGILCQG
     RGSAANSAVC YVLGITSIDP VRMGLLFERF ISAERGEPPD IDVDFEHERR EEVLQYVYQR
     YGRDRAGMVC EVITYRGKSA LRDVGKALGL SLGQVDRLAK LVGSYEDLGQ VGPELLAQAG
     LDAADSERVR MTLALARELQ GFPRHLSIHV GGFVITRRPL CETVPIEPAA MPGRTIVQWD
     KDDLAELDLL KVDLLGLGML TALSRALALL ARHRPAPASP TPVPHPDALA TIPAEDPEVY
     EMLGRADSIG VFQVESRAQM SLAPRLRPRN FYDLVISVAI IRPGPIQGGM IHPYLRRRDG
     KEQVRYPYAP LEPVLARTLG VPLFQEQAMR LAVIAAGFTP GEADELRRVM THRRSHEKLA
     AMKARLVAGM AERGISGADA EEIFKQLLGF AGYGFPESHA ASFALLVYAS AWLKRYHPAA
     FACALLNSQP MGFYAPHTLV EDAKRHGVEV RGVDVGCSGW ESSLEGAAPG RPAAPGEAAV
     LRVGLHAIRG LPRAVGEAIL EARAAGPFGS VAELVRRARL SRAWLVRLAE AGALGTLAPD
     RRGAVWRSLA VEADGGDLFA GLAPPEPEAA LPEASAADEV SADFTTTGLS VRGHPMALVR
     PGLGGDRIRT ARELGRLPDR APVEVAGLVI VRQRPETARG IVFVSLEDET GIANLVVMPD
     VYERFRPVVR GAPFLLARGR VERSGKVVNV RVDSVAPLAL APSMDARARD FH
//