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UniProtKB/Swiss-Prot entry Q2GK85

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDH_ANAPZ
Primary accession number Q2GK85
Secondary accession numbers None
Integrated into Swiss-Prot on June 27, 2006
Sequence was last modified on March 21, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 24)
Name and origin of the protein
Protein name Malate dehydrogenase
Synonym EC 1.1.1.37
Gene name
Name: mdh
OrderedLocusNames: APH_0629
From
Anaplasma phagocytophilum (strain HZ) [TaxID: 212042] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Anaplasmataceae; Anaplasma; phagocytophilum group.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1371/journal.pgen.0020021; PubMed=16482227 [NCBI, ExPASy, EBI, Israel, Japan]
Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V., Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M., Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N., Nelson W.C., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J.P., Daugherty S.C., Davidsen T., Durkin A.S., Gwinn M.L., Haft D.H., Selengut J.D., Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R., Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H.;
"Comparative genomics of emerging human ehrlichiosis agents.";
PLoS Genet. 2:208-222(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000235; ABD44326.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_505216.1; -.
3D structure databases
ModBase Q2GK85.
Enzyme and pathway databases
BioCyc APHA212042:APH_0629-MON; -.
Ontologies
GO
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00487; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR011275; Malate_DHase_NAD-dep_bac.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01763; MalateDH_bact; 1.
BLOCKS Q2GK85.
Genome annotation databases
GeneID 3930971; -.
GenomeReviews CP000235_GR; APH_0629.
KEGG aph:APH_0629; -.
NMPDR fig|212042.5.peg.616; -.
TIGR APH_0629; -.
Phylogenomic databases
HOGENOM Q2GK85; -.
Other
ProtoNet Q2GK85.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   321  321     Malate dehydrogenase. PRO_0000241941
NP_BIND   13    18  6     NAD (By similarity). 
NP_BIND   123   125  3     NAD (By similarity). 
ACT_SITE   180   180        Proton acceptor (By similarity). 
BINDING   38    38        NAD (By similarity). 
BINDING   87    87        Substrate (By similarity). 
BINDING   93    93        Substrate (By similarity). 
BINDING   100   100        NAD (By similarity). 
BINDING   125   125        Substrate (By similarity). 
BINDING   156   156        Substrate (By similarity). 
Sequence information
Length: 321 AA [This is the length of the unprocessed precursor] Molecular weight: 33835 Da [This is the MW of the unprocessed precursor] CRC64: DA06315D62C004C8 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRSHRSVKVS LVGAGNIGGT LAYMLGVAGI CQELVFVDVM DGVPRGKLLD IGHALAISGV 

        70         80         90        100        110        120 
DITAVGGSDY AAIEGSDAIV VTAGLPRKEG MSREDLLMAN AAVIKGVAEN IRKYSPDAFV 

       130        140        150        160        170        180 
IVVTNPLDAM VWYMHQCSGL PVNKVVGMAG VLDSARFSFF LAKHMSVSVS SVSSVVLGGH 

       190        200        210        220        230        240 
GDLMLPLLKY STVGGVSVSD LISCGRLSSE DVHAIIERTR KGGEEIVKLL KSGSAYYAPA 

       250        260        270        280        290        300 
ASCMNMLESY LFDKRCVIPC SVGLDGKYGV NGGLFVGVPA VIGKNGVEEV IEYVLSQEER 

       310        320 
EIFEKSVGLI SNSVKIISEQ K
Q2GK85 in FASTA format

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