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UniProtKB/Swiss-Prot entry Q29C43


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NCASE_DROPS
Primary accession number Q29C43
Secondary accession numbers None
Integrated into Swiss-Prot on July 25, 2006
Sequence was last modified on April 4, 2006 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 18)
Name and origin of the protein
Protein name Neutral ceramidase [Precursor]
Synonyms N-CDase
NCDase
EC 3.5.1.23
Acylsphingosine deacylase
N-acylsphingosine amidohydrolase
Gene name
Name: CDase
ORFNames: GA13191
From
Drosophila pseudoobscura pseudoobscura (Fruit fly) [TaxID: 46245] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MV2-25;
DOI=10.1101/gr.3059305; PubMed=15632085 [NCBI, ExPASy, EBI, Israel, Japan]
Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.;
"Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution.";
Genome Res. 15:1-18(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CM000070; EAL26803.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_001357669.1; -.
3D structure databases
ModBase Q29C43.
Organism-specific databases
FlyBase FBgn0073228; Dpse\GA13191.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0017040; Molecular function: ceramidase activity (inferred from electronic annotation from EC).
GO:0006665; Biological process: sphingolipid metabolic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006823; Ceramidase_alk.
Graphical view of domain structure.
PANTHER PTHR12670; Ceramidase_alk; 1.
Pfam PF04734; Ceramidase_alk; 1.
Pfam graphical view of domain structure.
ProtoNet Q29C43.
Genome annotation databases
GeneID 4800384; -.
KEGG dpo:Dpse_GA13191; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glycoprotein; Hydrolase; Lipid metabolism; Secreted; Signal; Sphingolipid metabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    23  23     Potential. 
CHAIN   24   704  681     Neutral ceramidase. PRO_0000247107
ACT_SITE   276   276        Nucleophile (By similarity). 
CARBOHYD   230   230        N-linked (GlcNAc...) (Potential). 
CARBOHYD   362   362        N-linked (GlcNAc...) (Potential). 
CARBOHYD   550   550        N-linked (GlcNAc...) (Potential). 
CARBOHYD   598   598        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 704 AA [This is the length of the unprocessed precursor] Molecular weight: 78092 Da [This is the MW of the unprocessed precursor] CRC64: 6131255E84E15F38 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAISKIAFLA LIALSGLCGL ASATYKVGVG RADITGPPVE INFMGYANIK QVGRGIHTRV 

        70         80         90        100        110        120 
FARAFVVEDE KGNRVAFVSA DAGMMGYGLK REVIKRLQAR YGNLYHTDNV AISGTHTHGA 

       130        140        150        160        170        180 
PGGFLMHLLY DISILGFVPQ TFEVMAQGLY LCIKRATDNL VDGRIFLSKT TVLNVNINRS 

       190        200        210        220        230        240 
PTSYLRNPEE ERAQYEHDTD KTLTQLRFVD LENNLLGAFN WYAVHATSMN NTNRLVTSDN 

       250        260        270        280        290        300 
VGYAALLLEK EYNPNKMPGK GKFVGAFCSS NLGDVSPNIM GPKCSISGNE CDLLTSRCPA 

       310        320        330        340        350        360 
GEGECFASGP GRDMVESTQI LGQRLADAAL GLLNEQSQES TAREVTGDVR FIHQFVDMPN 

       370        380        390        400        410        420 
YNGSAYNPLS RKIDKIRGCQ PAMGYSFAAG TTDGPGAFSF EQGTTTDNPM WNFVRDFIAT 

       430        440        450        460        470        480 
PTQEDIKCHE PKPILLATGR ATFPYEWQPK IVSDQLLKIG DVIIAAVPCE FTTMAGRRLR 

       490        500        510        520        530        540 
NQIRAAASAA GGLDTEVIIA GLTNIYTSYT VTPEEYQAQR YEAASTIFGP HTHSIYMDVF 

       550        560        570        580        590        600 
ERLTKALMRN ETVEPGPSPP YMNDVMLSLN TGVLFDGHPI NTDFGYVKTQ PEKEYGINDT 

       610        620        630        640        650        660 
VKVTYISGNP RNNLFTEKTY FTVERKINED RWKVAYTDAS WETKMIWHRT NTILGFSDLE 

       670        680        690        700 
IYWNISPQTL PGVYRIRHSG EYKYILGGKY PYEGLSHSFT VKED 

Q29C43 in FASTA format

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