NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Small intestine;
DOI=10.1007/s003359900153; PubMed=8672129 [NCBI, ExPASy, EBI, Israel, Japan]
Winteroe A.K., Fredholm M., Davies W.;
"Evaluation and characterization of a porcine small intestine cDNA library: analysis of 839 clones.";
Mamm. Genome 7:509-517(1996).

Comments

FUNCTION: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity).
CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
SUBUNIT: Exists as an octamer composed of four MTCK homodimers (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side (By similarity).
MISCELLANEOUS: Mitochondrial creatine kinase binds cardiolipin (By similarity).
SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

F14801; CAA23265.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P12532; 1QK1. [HSSP ENTRY / PDB]

SMR

Q29577; 1-78.

ModBase

Q29577.

Family and domain databases

InterPro

IPR000749; ATP-gua_Ptrans.
IPR014746; Gln_synth/guanido_kin_cat.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.590.10; ATP-gua_Ptrans; 1.

PANTHER

PTHR11547; ATP-gua_Ptrans; 1.

Pfam

PF00217; ATP-gua_Ptrans; 1.
Pfam graphical view of domain structure.

PROSITE

PS00112; GUANIDO_KINASE; PARTIAL.

BLOCKS

Q29577.

Phylogenomic databases

HOVERGEN

Q29577; -.

Other

ProtoNet

Q29577.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Kinase; Membrane; Mitochondrion; Mitochondrion inner membrane; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 >78`	`>78`	`Creatine kinase, ubiquitous mitochondrial.`	`PRO_0000211983`
`NON_TER`	`1 1`
`NON_TER`	`78 78`

Sequence information

Length: 78 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 8606 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: E86C5944D2BAC4B7 [This is a checksum on the sequence]

        10         20         30         40         50         60 
PLLSKDSRFP KILENLRLQK RGTGGVDTAA TGESFDISNL DRLGKSEVEL VQLVIDGVNY 

        70 
LIDLANGRLE RGQDIRIP

Q29577 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools