ID   AMHR2_RABIT             Reviewed;         569 AA.
AC   Q28616;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   22-JUL-2008, entry version 58.
DE   RecName: Full=Anti-Muellerian hormone type-2 receptor;
DE            EC=2.7.11.30;
DE   AltName: Full=Anti-Muellerian hormone type II receptor;
DE            Short=AMH type II receptor;
DE   AltName: Full=MIS type II receptor;
DE   AltName: Full=MISRII;
DE            Short=MRII;
DE   Flags: Precursor;
GN   Name=AMHR2;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   MEDLINE=95089769; PubMed=7997230; DOI=10.1210/me.8.8.1006;
RA   di Clemente N., Wilson C., Faure E., Boussin L., Carmillo P.,
RA   Tizard R., Picard J.-Y., Vigier B., Josso N., Cate R.;
RT   "Cloning, expression, and alternative splicing of the receptor for
RT   anti-Muellerian hormone.";
RL   Mol. Endocrinol. 8:1006-1020(1994).
CC   -!- FUNCTION: On ligand binding, forms a receptor complex consisting
CC       of two type II and two type I transmembrane serine/threonine
CC       kinases. Type II receptors phosphorylate and activate type I
CC       receptors which autophosphorylate, then bind and activate SMAD
CC       transcriptional regulators. Receptor for anti-Muellerian hormone.
CC   -!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-
CC       protein] phosphate.
CC   -!- COFACTOR: Magnesium or manganese (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; U15025; AAA21875.1; -; mRNA.
DR   RefSeq; NP_001076263.1; -.
DR   UniGene; Ocu.1823; -.
DR   HSSP; P36897; 1IAS.
DR   GeneID; 100009599; -.
DR   HOVERGEN; Q28616; -.
DR   InterPro; IPR017193; Anti-muellerian_hrmn_rcpt_II.
DR   InterPro; IPR015771; Anti-muellerian_hrmn_rcpt_II_C.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_bd_CS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   PANTHER; PTHR23255:SF4; MIS_II_R; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   PIRSF; PIRSF037392; AMHRII; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; FALSE_NEG.
PE   2: Evidence at transcript level;
KW   ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane;
KW   Metal-binding; Nucleotide-binding; Receptor;
KW   Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
FT   SIGNAL        1     17       Potential.
FT   CHAIN        18    569       Anti-Muellerian hormone type-2 receptor.
FT                                /FTId=PRO_0000260266.
FT   TOPO_DOM     18    148       Extracellular (Potential).
FT   TRANSMEM    149    169       Potential.
FT   TOPO_DOM    170    569       Cytoplasmic (Potential).
FT   DOMAIN      201    511       Protein kinase.
FT   NP_BIND     207    215       ATP (By similarity).
FT   COMPBIAS    149    162       Poly-Leu.
FT   ACT_SITE    331    331       Proton acceptor (By similarity).
FT   BINDING     228    228       ATP (By similarity).
FT   CARBOHYD     66     66       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    119    119       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   569 AA;  61099 MW;  388800F0ECAA5AAB CRC64;
     MLGTLGLWAL LPAAVQAPPN RRTCVFFEAP GVRGSTKTLG ELLDAGPGPP RVIRCLYSRC
     CFGIWNLTRD QAQVEMQGCR DSDEPGCESL SCDPSPRARA SSGSTLFTCS CGADFCNANY
     SHLPPLGGPG TPGPQGPQAA PGESPWMALA LLGLVLLLLL LLGGIVVALL QRKAYRVQSG
     PEPEPDSGRD CSEELPELPQ LCFSQVIREG GHAAVWAGQL QGELVAIKVF PRRAVAQFRA
     ERALYELPGL QHNHVVRFIA AGQGGPGPLP SGPLLVLELH PKGSLCQYLS QHTSDWGSSL
     RMALSLAQGL AFLHEERWQD GQYKPGIAHR DLSSQNVLIR EDGSCAIGDL GLALVLPGFA
     QPRAWAPPQP RGPAAIMEAG TQRYMAPELL DKSLDLQDWG TALRRADVYS LALLLWEILS
     RCPDLRPDGR PPPFQLAYEA ELGSAPTTCE LWALAVEERR RPDIPSSWCC FATDPGGLRE
     LLEDCWDADP EARLTAECVQ QRLVALVHPQ EAQPCPEGRP HSHPEDWPPA PAPAPALLPG
     SPQPGACHFG VQQGLCSRNP GAACASSDV
//