ID   AVR2A_SHEEP             Reviewed;         513 AA.
AC   Q28560;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   22-JUL-2008, entry version 63.
DE   RecName: Full=Activin receptor type-2A;
DE            EC=2.7.11.30;
DE   AltName: Full=Activin receptor type IIA;
DE            Short=ACTR-IIA;
DE   Flags: Precursor;
GN   Name=ACVR2A; Synonyms=ACTRII, ACVR2;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Romney; TISSUE=Ovarian follicle;
RA   Tisdall D.J.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: On ligand binding, forms a receptor complex consisting
CC       of two type II and two type I transmembrane serine/threonine
CC       kinases. Type II receptors phosphorylate and activate type I
CC       receptors which autophosphorylate, then bind and activate SMAD
CC       transcriptional regulators. Receptor for activin A, activin B and
CC       inhibin A.
CC   -!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-
CC       protein] phosphate.
CC   -!- COFACTOR: Magnesium or manganese (By similarity).
CC   -!- SUBUNIT: Interacts with AIP1. Part of a complex consisting of
CC       AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; L19442; AAA91903.1; -; mRNA.
DR   RefSeq; NP_001009293.1; -.
DR   UniGene; Oar.414; -.
DR   HSSP; P27038; 1BTE.
DR   SMR; Q28560; 26-119.
DR   GeneID; 443304; -.
DR   HOVERGEN; Q28560; -.
DR   InterPro; IPR000333; Activin_II_recpt.
DR   InterPro; IPR015768; Activin_II_recpt_C.
DR   InterPro; IPR000472; Activin_rcpt.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_bd_CS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   PANTHER; PTHR23255:SF10; Activin_II_recpt_C; 1.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   PRINTS; PR00653; ACTIVIN2R.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane;
KW   Metal-binding; Nucleotide-binding; Receptor;
KW   Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
FT   SIGNAL        1     19       Potential.
FT   CHAIN        20    513       Activin receptor type-2A.
FT                                /FTId=PRO_0000024400.
FT   TOPO_DOM     20    135       Extracellular (Potential).
FT   TRANSMEM    136    161       Potential.
FT   TOPO_DOM    162    513       Cytoplasmic (Potential).
FT   DOMAIN      192    485       Protein kinase.
FT   NP_BIND     198    206       ATP (By similarity).
FT   ACT_SITE    322    322       Proton acceptor (By similarity).
FT   BINDING     219    219       ATP (By similarity).
FT   CARBOHYD     43     43       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     66     66       N-linked (GlcNAc...) (Potential).
FT   DISULFID     30     60       By similarity.
FT   DISULFID     50     78       By similarity.
FT   DISULFID     85    104       By similarity.
FT   DISULFID     91    103       By similarity.
FT   DISULFID    105    110       By similarity.
SQ   SEQUENCE   513 AA;  57768 MW;  7231BF9E85CA57E3 CRC64;
     MGAAAKLAFA VFLISCSSGA ILGRSETQEC IFYNANWERD RTNRTGVESC YGDKDKRRHC
     FATWKNISSS IDIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NERFSYFPEM
     EVTQPTSNPV TPKPPYYNIL LYSLVPLMLV AGIVICAFWV YRHHKMAYPP VLVPTQDPGP
     PPPSPLLGLK PLQLLEVKAR GGFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG
     MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL
     AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV
     GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFVEEIG
     QHPSLEDMQE VVVHKKKRPV LRDYWQKLAG MAMLCETIEE CWDHDAEARL SAGCVGERIT
     QMQRLTNIIT TEDIVTVVTV VTNVDFPPKE SSL
//