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UniProtKB/Swiss-Prot entry Q28480

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH3A_MACFA
Primary accession number Q28480
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on July 15, 1998 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 49)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial [Precursor] [Fragment]
Synonyms EC 1.1.1.41
Isocitric dehydrogenase
NAD(+)-specific ICDH
Gene name
Name: IDH3A
From
Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) [TaxID: 9541] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Testis;
PubMed=7575427 [NCBI, ExPASy, EBI, Israel, Japan]
Nichols B.J., Perry A.C.F., Hall L., Denton R.M.;
"Molecular cloning and deduced amino acid sequences of the alpha- and beta-subunits of mammalian NAD(+)-isocitrate dehydrogenase.";
Biochem. J. 310:917-922(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X87172; CAA60637.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S58664; S58664.
3D structure databases
HSSP P08200; 1ISO. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
ModBase Q28480.
Family and domain databases
InterPro IPR004434; IsoCit_DHase_NAD_mit.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00175; mito_nad_idh; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q28480.
Phylogenomic databases
HOVERGEN Q28480; -.
Other
ProtoNet Q28480.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Magnesium; Manganese; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Transit peptide; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   <1     8  >8     Mitochondrion (By similarity). 
CHAIN   9   347  339     Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial. PRO_0000014437
NP_BIND   14    42  29     NAD (Potential). 
METAL   214   214        Magnesium or manganese (By similarity). 
METAL   238   238        Magnesium or manganese (By similarity). 
METAL   242   242        Magnesium or manganese (By similarity). 
BINDING   96    96        Substrate (By similarity). 
BINDING   106   106        Substrate (By similarity). 
BINDING   127   127        Substrate (By similarity). 
BINDING   214   214        Substrate (By similarity). 
SITE   134   134  1     Critical for catalysis (By similarity). 
SITE   181   181  1     Critical for catalysis (By similarity). 
NON_TER   1     1         
Sequence information
Length: 347 AA [This is the length of the partial sequence of the unprocessed precursor] Molecular weight: 37598 Da [This is the MW of the partial sequence of the unprocessed precursor] CRC64: 9100B663642131B9 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
QKQVTRGFTG GVQTVTLIPG DGIGPEISAA VMKIFDAAKA PIQWEERNVT AIQGPGGKWM 

        70         80         90        100        110        120 
IPSEAKESMD KNKMGLKGPL KTPIAAGHPS MNLLLRKTFD LYANVRPCVS IEGYKTPYTD 

       130        140        150        160        170        180 
VNIVTIRENT EGEYSGIEHV IVDGVVQSIK LITEGGSKRI AEFAFEYARN NHRSNVTAVH 

       190        200        210        220        230        240 
KANIMRMSDG LFLQKCREVA ENCKDIKFNE MYLDTVCLNM VQDPSQFDVL VMPNLYGDIL 

       250        260        270        280        290        300 
SDLCAGLIGG LGVTPSGNIG ANGVAIFESV HGTAPDIAGK DMANPTALLL SAVMMLRHMG 

       310        320        330        340 
LFDHAARIEA ACFATIKDGK SLTKDLGGNA KCSDFTEEIC RRVKDLD
Q28480 in FASTA format

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