ID   ACVR1_BOVIN             Reviewed;         509 AA.
AC   Q28041;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   22-JUL-2008, entry version 67.
DE   RecName: Full=Activin receptor type-1;
DE            EC=2.7.11.30;
DE   AltName: Full=Activin receptor type I;
DE            Short=ACTR-I;
DE   AltName: Full=Serine/threonine-protein kinase receptor R1;
DE            Short=SKR1;
DE   Flags: Precursor;
GN   Name=ACVR1; Synonyms=ACVRLK2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Ethier J.-F., Lussier J.G., Daneau I., Silversides D.W.;
RT   "Bovine activin receptor type I can be expressed as a kinase-domain
RT   truncated receptor.";
RL   Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: On ligand binding, forms a receptor complex consisting
CC       of two type II and two type I transmembrane serine/threonine
CC       kinases. Type II receptors phosphorylate and activate type I
CC       receptors which autophosphorylate, then bind and activate SMAD
CC       transcriptional regulators. Receptor for TGF-beta. May also bind
CC       activin.
CC   -!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-
CC       protein] phosphate.
CC   -!- COFACTOR: Magnesium or manganese (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC   -!- SIMILARITY: Contains 1 GS domain.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; U58095; AAB02696.1; -; mRNA.
DR   UniGene; Bt.16020; -.
DR   HSSP; P36897; 1IAS.
DR   Ensembl; ENSBTAG00000011909; Bos taurus.
DR   HOVERGEN; Q28041; -.
DR   GO; GO:0048179; C:activin receptor complex; ISS:AgBase.
DR   GO; GO:0016361; F:activin receptor activity, type I; ISS:AgBase.
DR   GO; GO:0050431; F:transforming growth factor beta binding; ISS:AgBase.
DR   GO; GO:0007368; P:determination of left/right symmetry; ISS:AgBase.
DR   GO; GO:0007281; P:germ cell development; ISS:AgBase.
DR   GO; GO:0007507; P:heart development; ISS:AgBase.
DR   GO; GO:0001701; P:in utero embryonic development; ISS:AgBase.
DR   GO; GO:0001755; P:neural crest cell migration; ISS:AgBase.
DR   GO; GO:0007179; P:transforming growth factor beta receptor si...; ISS:AgBase.
DR   GO; GO:0001655; P:urogenital system development; ISS:AgBase.
DR   InterPro; IPR000333; Activin_II_recpt.
DR   InterPro; IPR000472; Activin_rcpt.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_bd_CS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR003605; TGF_beta_rcpt_GS.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   PRINTS; PR00653; ACTIVIN2R.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00467; GS; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane;
KW   Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor;
KW   Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
FT   SIGNAL        1     20       By similarity.
FT   CHAIN        21    509       Activin receptor type-1.
FT                                /FTId=PRO_0000024393.
FT   TOPO_DOM     21    123       Extracellular (Potential).
FT   TRANSMEM    124    146       Potential.
FT   TOPO_DOM    147    509       Cytoplasmic (Potential).
FT   DOMAIN      178    207       GS.
FT   DOMAIN      208    502       Protein kinase.
FT   NP_BIND     214    222       ATP (By similarity).
FT   ACT_SITE    336    336       Proton acceptor (By similarity).
FT   BINDING     235    235       ATP (By similarity).
FT   MOD_RES     501    501       Phosphoserine (By similarity).
FT   CARBOHYD    102    102       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   509 AA;  57190 MW;  365B9D4A518773FB CRC64;
     MVDGVMILPV LVMIAFPFPS MEDEKPKVNP KLYMCVCEGL SCGDEAHCEG QQCFSSLSIN
     DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQNF
     HLEVGLIILS VVFAVCLLAC LLGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL
     ADLLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR
     DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL
     DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC CIADLGLAVM
     HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS
     NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ
     NPSARLTALR IKKTLTKIDN SLDKLKTDC
//