[1]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=HM-1:IMSS; PubMed=8705667 [NCBI, ExPASy, EBI, Israel, Japan] Kimura A., Hara Y., Kimoto T., Okuno Y., Minekawa Y., Nakabayashi T.; "Cloning and expression of a putative alcohol dehydrogenase gene of Entamoeba histolytica and its application to immunological examination."; Clin. Diagn. Lab. Immunol. 3:270-274(1996).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=HM-1:IMSS; PubMed=8611619 [NCBI, ExPASy, EBI, Israel, Japan] Rodriguez M.A., Baez-Camargo M., Delgadillo D.M., Orozco E.; "Cloning and expression of an Entamoeba histolytica NAPD+(-)dependent alcohol dehydrogenase gene."; Biochim. Biophys. Acta 1306:23-26(1996).

Comments

FUNCTION: NADP-dependent ADH activity.
CATALYTIC ACTIVITY: An alcohol + NADP⁺ = an aldehyde + NADPH.
SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

D49910; BAA08651.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
Z48752; CAA88639.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S68143; S68143.

3D structure databases

ModBase

Q24857.

Family and domain databases

InterPro

IPR001670; Fe_AlcDHase.
Graphical view of domain structure.

Pfam

PF00465; Fe-ADH; 1.
Pfam graphical view of domain structure.

PROSITE

PS00913; ADH_IRON_1; FALSE_NEG.
PS00060; ADH_IRON_2; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 395`	`395`	`Alcohol dehydrogenase 3.`	`PRO_0000087836`
`CONFLICT`	`193 193`		`R -> I (in Ref. 2; CAA88639).`
`CONFLICT`	`235 242`		`TLENHQDY -> HKKIIKTI (in Ref. 2; CAA88639).`
`CONFLICT`	`273 283`		`Missing (in Ref. 2).`
`CONFLICT`	`307 309`		`VMR -> NE (in Ref. 2; CAA88639).`

Sequence information

Length: 395 AA [This is the length of the unprocessed precursor]

Molecular weight: 43485 Da [This is the MW of the unprocessed precursor]

CRC64: 506FBBA933631FA9 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTMLNFTYYN PVRLIYGKGS LDEIEKQHLI PEDARIMMTY GGGSIKKNGV YEEVLKHIKP 

        70         80         90        100        110        120 
IVEFGGIEPN PSHETCIKAI KIAKENKINF LVAVGGGSII DATKYIALGM EHTYSDDPYD 

       130        140        150        160        170        180 
ICLKGGKFKV NPAQAKIGVV LTIPATGSET NCWGVISRHA DKLKLPFNNE SVFPTWSIVD 

       190        200        210        220        230        240 
PCFTMSLPDN QIRNGLVDSF VHCIEQYIGN YHLNPVVEAE TEGVMRTIIG VSHKTLENHQ 

       250        260        270        280        290        300 
DYQARITFCY AATVALNMSL LCGVTLCGGA HAVGVTLCGG AHAVGHELTS YYGLAHGETL 

       310        320        330        340        350        360 
AITTPGVMRF NKEKNAKKLI QMGEQVFGIK NSTPEAAIEA TEKWFKSIGM KTRLSEWGKG 

       370        380        390 
KEEFETIARK FEGNPAGAHK DIDYKGCLQI LNDIY

Q24857 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools