NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).

Comments

FUNCTION: Catalyzes the NADPH-dependent reduction of L-xylulose, D-xylulose, D-fructose, and L-sorbose, with the highest affinity for L-xylulose (By similarity).
CATALYTIC ACTIVITY: Xylitol + NADP⁺ = L-xylulose + NADPH.
PATHWAY: Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungi route): step 3/5 .
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Z75527; CAJ80819.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
Z75547; CAJ80819.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
Z75547; CAA99897.2; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
Z75527; CAA99897.2; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

T24180; T24180.

NP_506182.2; -.

3D structure databases

HSSP

P29132; 1LXC. [HSSP ENTRY / PDB]

ModBase

Q21929.

Organism-specific databases

WormBase

WBGene00000984; dhs-21.

WormPep

R11D1.11; CE39954. [WormPep / WorfDB]

Gene expression databases

ArrayExpress

Q21929; -.

Family and domain databases

InterPro

IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410; ADH_short_C2; 1.

Pfam

PF00106; adh_short; 1.
Pfam graphical view of domain structure.

PRINTS

PR00081; GDHRDH.
PR00080; SDRFAMILY.

PROSITE

PS00061; ADH_SHORT; 1.

BLOCKS

Q21929.

Genome annotation databases

Ensembl

R11D1.11; Caenorhabditis elegans. [Contig view]

GeneID

179741; -.

KEGG

cel:R11D1.11; -.

Other

ProtoNet

Q21929.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Carbohydrate metabolism; Complete proteome; NADP; Oxidoreductase; Xylose metabolism.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 251`	`251`	`Probable L-xylulose reductase.`	`PRO_0000054549`
`NP_BIND`	`11 41`	`31`	`NADP (By similarity).`
`COMPBIAS`	`203 206`	`4`	`Poly-Lys.`
`ACT_SITE`	`156 156`		`Proton acceptor (By similarity).`
`BINDING`	`143 143`		`Substrate (By similarity).`

Sequence information

Length: 251 AA [This is the length of the unprocessed precursor]

Molecular weight: 27219 Da [This is the MW of the unprocessed precursor]

CRC64: CB760AD64210E146 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPANYDFTDK RILVTGASQG IGKEICLSLA KAGAQVIAFA RNEANLLSLV KETTSLRYTI 

        70         80         90        100        110        120 
IPIVGDVSAN EEVLFKLIVP HFPIHGLVNN AGIATNHAIG QITQQSIDRT FAVNVRGPIL 

       130        140        150        160        170        180 
IAQLVARNFV DRQIKGSIVN ISSQAAIRPL DNHTVYCASK AALDMVTRCL ANELGSQNIR 

       190        200        210        220        230        240 
VNSVNPTVVM TDMGRDNWSD PDKKKKMLDR MPIKRFAEVD EVVNAVLFLL SDNASMTTGS 

       250 
TLPVDGGFSN N

Q21929 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools