NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/j.mce.2005.10.014; PubMed=16337734 [NCBI, ExPASy, EBI, Israel, Japan]
Keller B., Ohnesorg T., Mindnich R., Gloeckner C.J., Breitling R., Scharfe M., Moeller G., Bloecker H., Adamski J.;
"Interspecies comparison of gene structure and computational analysis of gene regulation of 17beta-hydroxysteroid dehydrogenase type 1.";
Mol. Cell. Endocrinol. 248:168-171(2006).

Comments

FUNCTION: Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
CATALYTIC ACTIVITY: Estradiol-17-beta + NAD(P)⁺ = estrone + NAD(P)H.
PATHWAY: Steroid metabolism; estrogen biosynthesis .
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

DQ023266; AAZ22356.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

Q1WNP0; 1-285, 2-286.

ModBase

Q1WNP0.

Family and domain databases

InterPro

IPR011348; 17beta_DHase.
IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410:SF47; 17beta_DH; 1.
PTHR19410; ADH_short_C2; 1.

Pfam

PF00106; adh_short; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000095; 17beta-HSD; 1.

PRINTS

PR00081; GDHRDH.
PR00080; SDRFAMILY.

PROSITE

PS00061; ADH_SHORT; 1.

BLOCKS

Q1WNP0.

Genome annotation databases

Ensembl

ENSPTRG00000009205; Pan troglodytes. [Contig view]

Phylogenomic databases

HOVERGEN

Q1WNP0; -.

Other

ProtoNet

Q1WNP0.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Lipid synthesis; NADP; Oxidoreductase; Steroid biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 328`	`327`	`Estradiol 17-beta-dehydrogenase 1.`	`PRO_0000251152`
`NP_BIND`	`10 38`	`29`	`NADP (By similarity).`
`ACT_SITE`	`156 156`		`Proton acceptor (By similarity).`
`BINDING`	`66 66`		`NADP (By similarity).`
`BINDING`	`143 143`		`Substrate (By similarity).`
`BINDING`	`160 160`		`NADP (By similarity).`

Sequence information

Length: 328 AA [This is the length of the unprocessed precursor]

Molecular weight: 34889 Da [This is the MW of the unprocessed precursor]

CRC64: D390680343130598 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA RALACPPGSL 

        70         80         90        100        110        120 
ETLQLDVRDS KSVAAARERV TEGRVDVLVC NAGLGLLGPL EALGEDAVAS VLDVNVVGTV 

       130        140        150        160        170        180 
RVLQAFLPDM KRRGSGRVLV TGSVGGLMGL PFNDVYCASK FALEGLCESL AVLLLPFGVH 

       190        200        210        220        230        240 
LSLIECGPVH TAFMEKVLGS PEEVLDRTDI HTFHRFYQYL AHSKQVFREA AQNPEEVAEV 

       250        260        270        280        290        300 
FLTALRAPKP TLRYFTTERF LPLLRMRLDD PSGSNYVTAM HREVFGDVPA KAEAGAEAGG 

       310        320 
GAGPGAEDEA GPSAVGDPEL GDPPAAPQ

Q1WNP0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools