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UniProtKB/Swiss-Prot entry Q1RJU4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH_RICBR
Primary accession number Q1RJU4
Secondary accession numbers None
Integrated into Swiss-Prot on June 26, 2007
Sequence was last modified on May 16, 2006 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 21)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP]
Synonyms IDH
EC 1.1.1.42
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
Gene name
Name: icd
OrderedLocusNames: RBE_0289
From
Rickettsia bellii (strain RML369-C) [TaxID: 336407] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Rickettsiaceae; Rickettsieae; Rickettsia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1371/journal.pgen.0020076; PubMed=16703114 [NCBI, ExPASy, EBI, Israel, Japan]
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.;
"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens.";
PLoS Genet. 2:733-744(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000087; ABE04370.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_537459.1; -.
3D structure databases
ModBase Q1RJU4.
Enzyme and pathway databases
BioCyc RBEL336407:RBE_0289-MON; -.
Family and domain databases
InterPro IPR001804; IsoCit_IM_DHase.
IPR014273; Isocitrate_DH_bac.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR02924; ICDH_alpha; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q1RJU4.
Genome annotation databases
GeneID 3995512; -.
GenomeReviews CP000087_GR; RBE_0289.
KEGG rbe:RBE_0289; -.
Phylogenomic databases
HOGENOM Q1RJU4; -.
Genome annotation databases
CMR Q1RJU4; RBE_0289.
Other
ProtoNet Q1RJU4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glyoxylate bypass; Magnesium; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   483  483     Isocitrate dehydrogenase [NADP]. PRO_0000292202
METAL   208   208        Magnesium or manganese (By similarity). 
METAL   232   232        Magnesium or manganese (By similarity). 
METAL   236   236        Magnesium or manganese (By similarity). 
BINDING   89    89        Substrate (By similarity). 
BINDING   99    99        Substrate (By similarity). 
BINDING   121   121        Substrate (By similarity). 
BINDING   208   208        Substrate (By similarity). 
SITE   128   128  1     Critical for catalysis (By similarity). 
SITE   175   175  1     Critical for catalysis (By similarity). 
MOD_RES   83    83        Phosphoserine (By similarity). 
Sequence information
Length: 483 AA [This is the length of the unprocessed precursor] Molecular weight: 53959 Da [This is the MW of the unprocessed precursor] CRC64: D02F3B5F38A5FF9D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAEFTPITIA YGDGIGPEIM EAVLYILRKA EARIRLETIE VGEKLYVKHY SSGISEQSWE 

        70         80         90        100        110        120 
SIERTGVILK APITTPQGGG YKSLNVTIRK TLQLFANIRP SVSFYPFTKT LHPNLNLTII 

       130        140        150        160        170        180 
RENEEDLYAG IEYRQTHNMY ESVKLISRTG CEKIIRYAFE YAVKNNRKKV TCLSKDNIMK 

       190        200        210        220        230        240 
FSDGIFHKVF NEIAKEYPQI NNEHYIIDIG TARLATKPEI FDVIVTSNLY GDIISDVAAE 

       250        260        270        280        290        300 
ISGSVGLAGS ANIGEHYAMF EAVHGSAPDI AGQDIANPSG LLNAAIMMLV HIGQGDIATL 

       310        320        330        340        350        360 
IENAWKKTIE DGMHTADIYN KDHSTKKVGT KEFAEEVVKR LGQKPEKLAK ADYPLVTKKQ 

       370        380        390        400        410        420 
ESNTTYKINT KEVKKLVGTD IFVGMNVASA HDIADKVNKL DIGNFELKTI SSKGLKLWPR 

       430        440        450        460        470        480 
DTRFETISDH WCCRFMAKDG VELKHLDITK LLETLSKANI DFIKVENLFE FDGAAGYSLA 


QGE
Q1RJU4 in FASTA format

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