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UniProtKB/Swiss-Prot entry Q1QUR0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LEU3_CHRSD
Primary accession number Q1QUR0
Secondary accession numbers None
Integrated into Swiss-Prot on September 19, 2006
Sequence was last modified on September 19, 2006 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 21)
Name and origin of the protein
Protein name 3-isopropylmalate dehydrogenase
Synonyms EC 1.1.1.85
Beta-IPM dehydrogenase
IMDH
3-IPM-DH
Gene name
Name: leuB
OrderedLocusNames: Csal_2451
From
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [TaxID: 290398] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales; Halomonadaceae; Chromohalobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N., O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R., Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D., Canovas D., Richardson P.;
"Complete sequence of Chromohalobacter salexigens DSM 3043.";
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000285; ABE59798.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_574497.1; -.
3D structure databases
ModBase Q1QUR0.
Enzyme and pathway databases
BioCyc CSAL290398:CSAL_2451-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003862; Molecular function: 3-isopropylmalate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009098; Biological process: leucine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01033; -; 1.
PBIL [Tree]
InterPro IPR004429; 3-isopropylmalate_DHase.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF13; IPMDH; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00169; leuB; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q1QUR0.
Genome annotation databases
GeneID 4026971; -.
GenomeReviews CP000285_GR; Csal_2451.
KEGG csa:Csal_2451; -.
NMPDR fig|290398.4.peg.3092; -.
Phylogenomic databases
HOGENOM Q1QUR0; -.
Genome annotation databases
CMR Q1QUR0; Csal_2451.
Other
ProtoNet Q1QUR0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Leucine biosynthesis; Magnesium; Manganese; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   359  359     3-isopropylmalate dehydrogenase. PRO_0000250112
NP_BIND   281   293  13     NAD (By similarity). 
METAL   223   223        Magnesium or manganese (By similarity). 
METAL   247   247        Magnesium or manganese (By similarity). 
METAL   251   251        Magnesium or manganese (By similarity). 
BINDING   96    96        Substrate (By similarity). 
BINDING   106   106        Substrate (By similarity). 
BINDING   134   134        Substrate (By similarity). 
BINDING   223   223        Substrate (By similarity). 
SITE   141   141  1     Important for catalysis (By similarity). 
SITE   191   191  1     Important for catalysis (By similarity). 
Sequence information
Length: 359 AA [This is the length of the unprocessed precursor] Molecular weight: 38363 Da [This is the MW of the unprocessed precursor] CRC64: A6569DD652F0CF1B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSRKILVLPG DGIGPEITRE AVKILNACRE AGLEASIEEG LVGGAGIDAH GVPLPDETLA 

        70         80         90        100        110        120 
SAKAADAVLL GAVGGPQWDK IEDLSKRPEK GLLGLRKNLN LFGNLRPALL YPQLASASSL 

       130        140        150        160        170        180 
KPEIVAGLDI MIVRELTGGI YFGQPRGIEE RDGERVGYNT YIYAEHEIER IGRVAFEMAR 

       190        200        210        220        230        240 
ERGGKLCSVD KANVLEATIL WREVMERLAP EYPDVALSHM YVDNAAMQLV RAPKQFDVIV 

       250        260        270        280        290        300 
TGNMFGDILS DAAAMLTGSI GMLPSASLNE QRQGMYEPCH GSAPDIAGQG IANPLATILS 

       310        320        330        340        350 
VAMMLRYSLE APQLAERIER AVGTVLDQGL RTADIAFEGT APVSTQAMGD AVLAAFQAQ
Q1QUR0 in FASTA format

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