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UniProtKB/Swiss-Prot entry Q1CTU5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_HELPH
Primary accession number Q1CTU5
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on July 11, 2006 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 21)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: HPAG1_0560
From
Helicobacter pylori (strain HPAG1) [TaxID: 357544] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0603784103; PubMed=16788065 [NCBI, ExPASy, EBI, Israel, Japan]
Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A., Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G., Gordon J.I.;
"The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression.";
Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000241; ABF84627.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_627301.1; -.
3D structure databases
ModBase Q1CTU5.
Enzyme and pathway databases
BioCyc HPYL357544:HPAG1_0560-MON; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00219; -; 1.
PBIL [Tree]
InterPro IPR006992; Amidohydro_2.
IPR004721; DHOdimr.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF04909; Amidohydro_2; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001237; DHOdimr; 1.
TIGRFAMs TIGR00856; pyrC_dimer; 1.
PROSITE PS00482; DIHYDROOROTASE_1; 1.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS Q1CTU5.
Genome annotation databases
GeneID 4099416; -.
GenomeReviews CP000241_GR; HPAG1_0560.
KEGG hpa:HPAG1_0560; -.
Phylogenomic databases
HOGENOM Q1CTU5; -.
Genome annotation databases
CMR Q1CTU5; HPAG1_0560.
Other
ProtoNet Q1CTU5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   339  339     Dihydroorotase. PRO_1000024017
METAL   12    12        Zinc 1 (By similarity). 
METAL   14    14        Zinc 1 (By similarity). 
METAL   94    94        Zinc 1; via carbamate group (By similarity). 
METAL   94    94        Zinc 2; via carbamate group (By similarity). 
METAL   133   133        Zinc 2 (By similarity). 
METAL   167   167        Zinc 2 (By similarity). 
METAL   239   239        Zinc 1 (By similarity). 
MOD_RES   94    94        N6-carboxylysine (By similarity). 
Sequence information
Length: 339 AA [This is the length of the unprocessed precursor] Molecular weight: 38044 Da [This is the MW of the unprocessed precursor] CRC64: E8FC35F5706158CA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEITLFDPID AHLHVRENAL LKAVLRYSSE PFSAAVIMPN LSKPLIDTPT TLEYEEEILK 

        70         80         90        100        110        120 
NSSNFKPLMS LYFNDDLTLE ELQRAHEKGV RFLKLYPKGM TTNAQNGTSD LLDEKTLEIL 

       130        140        150        160        170        180 
ENAQKLGFIL CIHAEQAGFC LDKEFLCHSV LETFALSFPK LKIIIEHLSD WRSIALIEKH 

       190        200        210        220        230        240 
DNLYATLTLH HISMTLDDLL GGSLNPHCFC KPLIKTKKDQ ERLLSLALKA HPKISFGSDS 

       250        260        270        280        290        300 
APHFVSKKHS ANIPAGIFSA PILLPALCEL FEKHNALENL QAFISNNAKT IYGLDNLPSK 

       310        320        330 
KARLSKKPFI VPTHALCLNE KIAILRGGET LSWNLQEIA
Q1CTU5 in FASTA format

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