[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Melanoma; DOI=10.1073/pnas.91.9.3515; PubMed=8170938 [NCBI, ExPASy, EBI, Israel, Japan] Kawakami Y., Eliyahu S., Delgado C.H., Robbins P.F., Rivoltini L., Topalian S.L., Miki T., Rosenberg S.A.; "Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor."; Proc. Natl. Acad. Sci. U.S.A. 91:3515-3519(1994).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1084/jem.180.1.35; PubMed=8006593 [NCBI, ExPASy, EBI, Israel, Japan] Coulie P.G., Brichard V., van Pel A., Woelfel T., Schneider J., Traversari C., Mattei S., de Plaen E., Lurquin C., Szikora J.-P., Renauld J.-C., Boon T.; "A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas."; J. Exp. Med. 180:35-42(1994).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Skin; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
TISSUE SPECIFICITY: Expression is restricted to melanoma and melanocyte cell lines and retina.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U06452; AAA19238.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U06654; AAA20389.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC014423; AAH14423.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00003426; -.

A55253; A55253.

NP_005502.1; -.

3D structure databases

PDB

2GT9; X-ray; 1.75 A; C/F=26-35.	[ExPASy / RCSB / EBI]
2GTW; X-ray; 1.55 A; C/F=28-35.	[ExPASy / RCSB / EBI]
2GTZ; X-ray; 1.70 A; C/F=29-35.	[ExPASy / RCSB / EBI]
2GUO; X-ray; 1.90 A; C/F=27-35.	[ExPASy / RCSB / EBI]

Detailed list of linked structures.

PDBsum

2GT9; -.
2GTW; -.
2GTZ; -.
2GUO; -.

ModBase

Q16655.

Organism-specific databases

GC09P005880; -.

HIX0007904; -.

HGNC:7124; MLANA.

CAB000057; -.

605513; gene. [NCBI / EBI]

PharmGKB

PA30842; -.

Gene expression databases

Q16655; -.

Q16655; -.

HS_MLANA; -.

ENSG00000120215; Homo sapiens.

Ontologies

GO:0005887;	Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
QuickGo view.

Proteomic databases

PRIDE

Q16655; -.

Genome annotation databases

Ensembl

ENSG00000120215; Homo sapiens. [Contig view]

GeneID

2315; -.

KEGG

hsa:2315; -.

Phylogenomic databases

HOGENOM

Q16655; -.

HOVERGEN

Q16655; -.

OMA

Q16655; YRTLTDK.

Other

9401; -.

MLANA; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Membrane; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 118`	`118`	`Melanoma antigen recognized by T-cells 1.`	`PRO_0000096238`
`TRANSMEM`	`27 47`	`21`	`Potential.`

Sequence information

Length: 118 AA [This is the length of the unprocessed precursor]

Molecular weight: 13157 Da [This is the MW of the unprocessed precursor]

CRC64: B755BFF39CFCB16E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPREDAHFIY GYPKKGHGHS YTTAEEAAGI GILTVILGVL LLIGCWYCRR RNGYRALMDK 

        70         80         90        100        110 
SLHVGTQCAL TRRCPQEGFD HRDSKVSLQE KNCEPVVPNA PPAYEKLSAE QSPPPYSP

Q16655 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools