[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=7478596 [NCBI, ExPASy, EBI, Israel, Japan]
Choi S.S.,
Park I.-C.,
Yun J.W.,
Sung Y.C.,
Hong S.-I.,
Shin H.-S.;
"A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow.";
Oncogene 11:1693-1698(1995).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Umbilical vein;
PubMed=8605321 [NCBI, ExPASy, EBI, Israel, Japan]
Karsan A.,
Yee E.,
Kaushansky K.,
Harlan J.M.;
"Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells.";
Blood 87:3089-3096(1996).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=T-cell;
DOI=10.1038/sj.onc.1200898; PubMed=9050999 [NCBI, ExPASy, EBI, Israel, Japan]
Kenny J.J.,
Knobloch T.J.,
Augustus M.,
Carter K.C.,
Rosen C.A.,
Lang J.C.;
"GRS, a novel member of the Bcl-2 gene family, is highly expressed in multiple cancer cell lines and in normal leukocytes.";
Oncogene 14:997-1001(1997).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N.,
Chen X.,
Rolfs A.,
Halleck A.,
Hines L.,
Eisenstein S.,
Koundinya M.,
Raphael J.,
Moreira D.,
Kelley T.,
LaBaer J.,
Lin Y.,
Phelan M.,
Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS TYR-19; LYS-39 AND ASP-82.
Halleck A.,
Ebert L.,
Mkoundinya M.,
Schick M.,
Eisenstein S.,
Neubert P.,
Kstrang K.,
Schatten R.,
Shen B.,
Henze S.,
Mar W.,
Korn B.,
Zuo D.,
Hu Y.,
LaBaer J.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J.,
Istrail S.,
Sutton G.G.,
Florea L.,
Halpern A.L.,
Mobarry C.M.,
Lippert R.,
Walenz B.,
Shatkay H.,
Dew I.,
Miller J.R.,
Flanigan M.J.,
Edwards N.J.,
Bolanos R.,
Fasulo D.,
Halldorsson B.V.,
Hannenhalli S.,
Turner R.,
Yooseph S., ![]()
Lu F.,
Nusskern D.R.,
Shue B.C.,
Zheng X.H.,
Zhong F.,
Delcher A.L.,
Huson D.H.,
Kravitz S.A.,
Mouchard L.,
Reinert K.,
Remington K.A.,
Clark A.G.,
Waterman M.S.,
Eichler E.E.,
Adams M.D.,
Hunkapiller M.W.,
Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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[7]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[8]
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INTERACTION WITH BAX.
DOI=10.1006/bbrc.2000.2537; PubMed=10772918 [NCBI, ExPASy, EBI, Israel, Japan]
Schmitt E.,
Paquet C.,
Beauchemin M.,
Dever-Bertrand J.,
Bertrand R.;
"Characterization of Bax-sigma, a cell death-inducing isoform of Bax.";
Biochem. Biophys. Res. Commun. 270:868-879(2000).
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[9]
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X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 149-608 IN COMPLEX WITH BCL2L11.
Structural genomics consortium (SGC);
"Human BCL-2A1 in complex with BIM.";
Submitted (FEB-2008) to the PDB data bank.
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- FUNCTION: Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity).
- SUBUNIT: Interacts directly with BAK1, BID, BMF and BBC3 (By similarity). Interacts directly with BCL2L11/BIM. Interacts with BAX isoform Sigma.
- INTERACTION:
Q9BXH1:BBC3; NbExp=1; IntAct=EBI-1003550, EBI-519884;
O43521:BCL2L11; NbExp=1; IntAct=EBI-1003550, EBI-526406;
P55957:BID; NbExp=1; IntAct=EBI-1003550, EBI-519672;
P22736:NR4A1; NbExp=1; IntAct=EBI-1003550, EBI-721550;
- SUBCELLULAR LOCATION: Cytoplasm.
- TISSUE SPECIFICITY: Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies.
- INDUCTION: By phorbol ester and inflammatory cytokines, such as TNF-alpha, or IL-1-beta, but not by growth factors.
- SIMILARITY: Belongs to the Bcl-2 family.
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