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[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
TISSUE=Fibroblast;
DOI=10.1021/bi962209o; PubMed=8909283 [NCBI, ExPASy, EBI, Israel, Japan]
Hsu D.S.,
Zhao X.,
Zhao S.,
Kazantsev A.,
Wang R.-P.,
Todo T.,
Wei Y.-F.,
Sancar A.;
"Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins.";
Biochemistry 35:13871-13877(1996).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Testis;
DOI=10.1006/geno.1996.0539; PubMed=8921389 [NCBI, ExPASy, EBI, Israel, Japan]
van der Spek P.J.,
Kobayashi K.,
Bootsma D.,
Takao M.,
Eker A.P.M.,
Yasui A.;
"Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors.";
Genomics 37:177-182(1996).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Brain;
PubMed=8600518 [NCBI, ExPASy, EBI, Israel, Japan]
Todo T.,
Ryo H.,
Yamamoto K.,
Toh H.,
Inui T.,
Ayaki H.,
Nomura T.,
Ikenaga M.;
"Similarity among the Drosophila (6-4)photolyase, a human photolyase homolog, and the DNA photolyase-blue-light photoreceptor family.";
Science 272:109-112(1996).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[5]
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FUNCTION.
DOI=10.1126/science.286.5440.768; PubMed=10531061 [NCBI, ExPASy, EBI, Israel, Japan]
Griffin E.A. Jr.,
Staknis D.,
Weitz C.J.;
"Light-independent role of CRY1 and CRY2 in the mammalian circadian clock.";
Science 286:768-771(1999).
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- FUNCTION: Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL (By similarity).
- COFACTOR: Binds 1 FAD per subunit.
- COFACTOR: Binds 1 5,10-methenyltetrahydrofolate non-covalently per subunit.
- SUBUNIT: Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 C-terminal domains. Interaction with PER2 inhibits its ubiquitination and vice versa. Binds MAPK (By similarity).
- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated to the nucleus through interaction with other Clock proteins such as PER2 or ARNTL (By similarity).
- INDUCTION: Expression is regulated by light and circadian rhythms. Peak expression in the suprachiasma nucleus (SCN) and eye at the day/night transition (CT12). Levels decrease with ARNTL-CLOCK inhibition as part of the autoregulatory feedback loop.
- PTM: Phosphorylation on Ser-247 by MAPK is important for the inhibition of CLOCK-ARNTL-mediated transcriptional activity. Phosphorylation by CSNK1E requires interaction with PER1 or PER2 (By similarity).
- SIMILARITY: Belongs to the DNA photolyase class-1 family.
- SIMILARITY: Contains 1 DNA photolyase domain.
- WEB RESOURCE: Name=Wikipedia; Note=Cryptochrome entry; URL="http://en.wikipedia.org/wiki/Cryptochrome";.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 586 AA [This is the length of the unprocessed precursor] |
Molecular weight: 66395 Da [This is the MW of the unprocessed precursor] |
CRC64: 96A5B09A6364D3B9 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MGVNAVHWFR KGLRLHDNPA LKECIQGADT IRCVYILDPW FAGSSNVGIN RWRFLLQCLE
70 80 90 100 110 120
DLDANLRKLN SRLFVIRGQP ADVFPRLFKE WNITKLSIEY DSEPFGKERD AAIKKLATEA
130 140 150 160 170 180
GVEVIVRISH TLYDLDKIIE LNGGQPPLTY KRFQTLISKM EPLEIPVETI TSEVIEKCTT
190 200 210 220 230 240
PLSDDHDEKY GVPSLEELGF DTDGLSSAVW PGGETEALTR LERHLERKAW VANFERPRMN
250 260 270 280 290 300
ANSLLASPTG LSPYLRFGCL SCRLFYFKLT DLYKKVKKNS SPPLSLYGQL LWREFFYTAA
310 320 330 340 350 360
TNNPRFDKME GNPICVQIPW DKNPEALAKW AEGRTGFPWI DAIMTQLRQE GWIHHLARHA
370 380 390 400 410 420
VACFLTRGDL WISWEEGMKV FEELLLDADW SINAGSWMWL SCSSFFQQFF HCYCPVGFGR
430 440 450 460 470 480
RTDPNGDYIR RYLPVLRGFP AKYIYDPWNA PEGIQKVAKC LIGVNYPKPM VNHAEASRLN
490 500 510 520 530 540
IERMKQIYQQ LSRYRGLGLL ASVPSNPNGN GGFMGYSAEN IPGCSSSGSC SQGSGILHYA
550 560 570 580
HGDSQQTHLL KQGRSSMGTG LSGGKRPSQE EDTQSIGPKV QRQSTN
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Q16526 in FASTA format |
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ExPASy Home page
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