[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Cerebellum; PubMed=8632757 [NCBI, ExPASy, EBI, Israel, Japan] Hadingham K.L., Garrett E.M., Wafford K.A., Bain C., Heavens R.P., Sirinathsinghji D.J., Whiting P.J.; "Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors."; Mol. Pharmacol. 49:253-259(1996).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[3]	VARIANT [LARGE SCALE ANALYSIS] HIS-180. DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan] Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.; "The consensus coding sequences of human breast and colorectal cancers."; Science 314:268-274(2006).

Comments

FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
SUBUNIT: Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the ligand-gated ionic channel (TC 1.A.9) family [view classification].
WEB RESOURCE: Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http://www.expasy.org/spotlight/back_issues/sptlt056.shtml";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

S81944; AAB36480.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC096241; AAH96241.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC096242; AAH96242.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC099640; AAH99640.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC099641; AAH99641.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_000802.2; -.

UniGene

Hs.90791

3D structure databases

ModBase

Q16445.

PTM databases

PhosphoSite

Q16445; -.

Organism-specific databases

HIX0005382; -.

HGNC:4080; GABRA6.

137143; gene. [NCBI / EBI]

PharmGKB

PA28494; -.

GeneCards

Q16445.

Gene expression databases

ArrayExpress

Q16445; -.

CleanEx

HS_GABRA6; -.

GermOnline

ENSG00000145863; Homo sapiens.

Ontologies

GO:0005887;	Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0008503;	Molecular function: benzodiazepine receptor activity (traceable author statement from ProtInc).
GO:0007165;	Biological process: signal transduction (traceable author statement from ProtInc).
GO:0006810;	Biological process: transport (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR006028; GABAA_rcpt.
IPR001390; GABAAa_rcpt.
IPR005436; GABBAa6_rcpt.
IPR006029; Neu_channel_TM.
IPR006202; Neur_chan_lig_bd.
IPR006201; Neur_channel.
Graphical view of domain structure.

Gene3D

G3DSA:2.70.170.10; Neur_chan_lig_bd; 1.

PANTHER

PTHR18945; Neur_channel; 1.

Pfam

PF02931; Neur_chan_LBD; 1.
PF02932; Neur_chan_memb; 1.
Pfam graphical view of domain structure.

PRINTS

PR01079; GABAARALPHA.
PR01619; GABAARALPHA6.
PR00253; GABAARECEPTR.
PR00252; NRIONCHANNEL.

TIGRFAMs

TIGR00860; LIC; 1.

PROSITE

PS00236; NEUROTR_ION_CHANNEL; 1.

BLOCKS

Q16445.

Genome annotation databases

Ensembl

ENSG00000145863; Homo sapiens. [Contig view]

GeneID

2559; -.

KEGG

hsa:2559; -.

NMPDR

fig|9606.3.peg.26114; -.

Phylogenomic databases

HOGENOM

Q16445; -.

HOVERGEN

Q16445; -.

Other

DrugBank

DB00404; Alprazolam.
DB00189; Ethchlorvynol.
DB01544; Flunitrazepam.
DB00690; Flurazepam.
DB00186; Lorazepam.
DB00371; Meprobamate.
DB00683; Midazolam.

SOURCE

GABRA6; Homo sapiens.

ProtoNet

Q16445.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell junction; Cell membrane; Chloride; Chloride channel; Glycoprotein; Ion transport; Ionic channel; Membrane; Polymorphism; Postsynaptic cell membrane; Signal; Synapse; Transmembrane; Transport.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 19`	`19`	`Potential.`
`CHAIN`	`20 453`	`434`	`Gamma-aminobutyric acid receptor subunit alpha-6.`	`PRO_0000000447`
`TOPO_DOM`	`20 242`	`223`	`Extracellular (Probable).`
`TRANSMEM`	`243 264`	`22`	`Probable.`
`TRANSMEM`	`269 290`	`22`	`Probable.`
`TRANSMEM`	`301 324`	`24`	`Probable.`
`TOPO_DOM`	`325 419`	`95`	`Cytoplasmic (Probable).`
`TRANSMEM`	`420 441`	`22`	`Probable.`
`CARBOHYD`	`31 31`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`128 128`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`141 141`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`156 170`		`By similarity.`
`VARIANT`	`180 180`	`1`	`P -> H (in a colorectal cancer sample; somatic mutation).`	`VAR_036033`
`VARIANT`	`187 187`	`1`	`T -> M (in dbSNP:rs3811993 [NCBI]).`	`VAR_036782`
`VARIANT`	`404 404`	`1`	`P -> S (in dbSNP:rs34907804 [NCBI]).`	`VAR_036783`
`CONFLICT`	`408 408`		`S -> P (in Ref. 1; AAB36480).`

Sequence information

Length: 453 AA [This is the length of the unprocessed precursor]

Molecular weight: 51024 Da [This is the MW of the unprocessed precursor]

CRC64: 5C9F85845BC8E3B0 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MASSLPWLCI ILWLENALGK LEVEGNFYSE NVSRILDNLL EGYDNRLRPG FGGAVTEVKT 

        70         80         90        100        110        120 
DIYVTSFGPV SDVEMEYTMD VFFRQTWTDE RLKFGGPTEI LSLNNLMVSK IWTPDTFFRN 

       130        140        150        160        170        180 
GKKSIAHNMT TPNKLFRIMQ NGTILYTMRL TINADCPMRL VNFPMDGHAC PLKFGSYAYP 

       190        200        210        220        230        240 
KSEIIYTWKK GPLYSVEVPE ESSSLLQYDL IGQTVSSETI KSNTGEYVIM TVYFHLQRKM 

       250        260        270        280        290        300 
GYFMIQIYTP CIMTVILSQV SFWINKESVP ARTVFGITTV LTMTTLSISA RHSLPKVSYA 

       310        320        330        340        350        360 
TAMDWFIAVC FAFVFSALIE FAAVNYFTNL QTQKAKRKAQ FAAPPTVTIS KATEPLEAEI 

       370        380        390        400        410        420 
VLHPDSKYHL KKRITSLSLP IVSSSEANKV LTRAPILQST PVTPPPLSPA FGGTSKIDQY 

       430        440        450 
SRILFPVAFA GFNLVYWVVY LSKDTMEVSS SVE

Q16445 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools