[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 5), FUNCTION, AND TISSUE SPECIFICITY.
TISSUE=Fetal brain, Fetal liver, and Spleen;
PubMed=8756667 [NCBI, ExPASy, EBI, Israel, Japan]
Oettgen P.,
Akbarali Y.,
Boltax J.,
Best J.,
Kunsch C.,
Libermann T.A.;
"Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1.";
Mol. Cell. Biol. 16:5091-5106(1996).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
TISSUE=Chronic myeloid leukemia cell;
Wilkinson D.A.,
Neale G.A.M.,
Mao S.,
Fernandes E.R.,
Davenport J.W.,
Naeve C.W.,
Goorha R.M.;
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[4]
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INTERACTION WITH RUNX1.
PubMed=10207087 [NCBI, ExPASy, EBI, Israel, Japan]
Mao S.,
Frank R.C.,
Zhang J.,
Miyazaki Y.,
Nimer S.D.;
"Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.";
Mol. Cell. Biol. 19:3635-3644(1999).
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[5]
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FUNCTION, AND INTERACTION WITH RUNX1.
DOI=10.1074/jbc.M309074200; PubMed=14970218 [NCBI, ExPASy, EBI, Israel, Japan]
Cho J.-Y.,
Akbarali Y.,
Zerbini L.F.,
Gu X.,
Boltax J.,
Wang Y.,
Oettgen P.,
Zhang D.-E.,
Libermann T.A.;
"Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.";
J. Biol. Chem. 279:19512-19522(2004).
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[6]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0404720101; PubMed=15302935 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A.,
Jedrychowski M.,
Schwartz D.,
Elias J.E.,
Villen J.,
Li J.,
Cohn M.A.,
Cantley L.C.,
Gygi S.P.;
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
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[7]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363 AND SER-372, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N.,
Zhou C.,
Villen J.,
Beausoleil S.A.,
Bakalarski C.E.,
Elledge S.J.,
Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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- FUNCTION: Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter. Isoform 2 may function in repression of RUNX1-mediated transactivation.
- SUBUNIT: Interacts with the LIM domains of LMO2 (By similarity). Interacts via its N-terminal region with RUNX1.
- INTERACTION:
Q01196:RUNX1; NbExp=2; IntAct=EBI-956941, EBI-925904;
- SUBCELLULAR LOCATION: Nucleus.
- ALTERNATIVE PRODUCTS:
5 named isoforms [FASTA] produced by alternative splicing.
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| Name | 1 |
| Synonyms | NERF-2, NERF-2a |
| Isoform ID | Q15723-1 |
| Features which should be applied to build the isoform sequence: VSP_014155. |
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| Name | 3 |
| Synonyms | NERF-1b |
| Isoform ID | Q15723-3 |
| Features which should be applied to build the isoform sequence: VSP_014154. |
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- TISSUE SPECIFICITY: Expressed in all fetal and adult tissues examined. Among fetal tissues, highest levels of expression detected in heart, lung, liver and kidney, and lower levels in brain. Among adult tissues, highest levels of expression detected in heart, placenta, lung, skeletal muscle, spleen, thymus, testis and ovary. Moderate expression in prostate, small intestine, kidney, liver and pancreas, and weak expression in colon, brain and peripheral blood lymphocytes.
- SIMILARITY: Belongs to the ETS family.
- SIMILARITY: Contains 1 ETS DNA-binding domain.
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