[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[2]	NUCLEOTIDE SEQUENCE [MRNA] OF 126-282. TISSUE=Testis; DOI=10.1006/geno.1996.4490; PubMed=9119360 [NCBI, ExPASy, EBI, Israel, Japan] Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.; "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species."; Genomics 39:239-246(1997).
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 126-282. DOI=10.1006/geno.2002.6830; PubMed=12213199 [NCBI, ExPASy, EBI, Israel, Japan] Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.; "DEFOG: a practical scheme for deciphering families of genes."; Genomics 80:295-302(2002).
[4]	IDENTIFICATION. DOI=10.1073/pnas.0307882100; PubMed=14983052 [NCBI, ExPASy, EBI, Israel, Japan] Malnic B., Godfrey P.A., Buck L.B.; "The human olfactory receptor gene family."; Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[5]	ERRATUM. Malnic B., Godfrey P.A., Buck L.B.; Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
[6]	POLYMORPHISM. DOI=10.1371/journal.pbio.0050284; PubMed=17973576 [NCBI, ExPASy, EBI, Israel, Japan] Menashe I., Abaffy T., Hasin Y., Goshen S., Yahalom V., Luetje C.W., Lancet D.; "Genetic elucidation of human hyperosmia to isovaleric acid."; PLoS Biol. 5:2462-2468(2007).

Comments

FUNCTION: Odorant receptor (Potential).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
POLYMORPHISM: A stop codon in the gene coding for this protein at position Tyr-259 is responsible for functional diversity thus producing thus a pseudogene.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family [view classification].
WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); URL="http://bip.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR8G1";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB065946; BAC06159.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X89672; CAA61819.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF399507; AAK94992.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BK004423; DAA04821.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00099998; -.

S58017; S58017.

NP_001002905.1; -.

3D structure databases

ModBase

Q15617.

Protein family/group databases

GPCRDB

Q15617; OR8G1_HUMAN.

Organism-specific databases

GC11P123627; -.

HGNC:8484; OR8G1.

PA32764; -.

Gene expression databases

ArrayExpress

Q15617; -.

GermOnline

ENSG00000197849; Homo sapiens.

Ontologies

GO:0016021;	Cellular component: integral to membrane (non-traceable author statement from UniProtKB).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004984;	Molecular function: olfactory receptor activity (non-traceable author statement from UniProtKB).
GO:0007186;	Biological process: G-protein coupled receptor protein signaling pathway (inferred from electronic annotation from UniProtKB-KW).
GO:0050896;	Biological process: response to stimulus (inferred from electronic annotation from UniProtKB-KW).
GO:0007608;	Biological process: sensory perception of smell (non-traceable author statement from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR000276; 7TM_GPCR_Rhodpsn.
IPR017452; GPCR_Rhodpsn_supfam.
IPR000725; Olfact_rcpt.
Graphical view of domain structure.

PANTHER

PTHR11398; Olfact_rcpt; 1.

Pfam

PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.

PRINTS

PR00237; GPCRRHODOPSN.
PR00245; OLFACTORYR.

PROSITE

PS00237; G_PROTEIN_RECEP_F1_1; 1.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

Q15617; -.

Genome annotation databases

Ensembl

ENSG00000197849; Homo sapiens. [Contig view]

GeneID

26494; -.

KEGG

hsa:26494; -.

Phylogenomic databases

HOGENOM

Q15617; -.

HOVERGEN

Q15617; -.

Other

48752; -.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Olfaction; Polymorphism; Receptor; Sensory transduction; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 311`	`311`	`Olfactory receptor 8G1.`	`PRO_0000150662`
`TOPO_DOM`	`1 25`	`25`	`Extracellular (Potential).`
`TRANSMEM`	`26 46`	`21`	`1 (Potential).`
`TOPO_DOM`	`47 54`	`8`	`Cytoplasmic (Potential).`
`TRANSMEM`	`55 75`	`21`	`2 (Potential).`
`TOPO_DOM`	`76 99`	`24`	`Extracellular (Potential).`
`TRANSMEM`	`100 120`	`21`	`3 (Potential).`
`TOPO_DOM`	`121 139`	`19`	`Cytoplasmic (Potential).`
`TRANSMEM`	`140 160`	`21`	`4 (Potential).`
`TOPO_DOM`	`161 197`	`37`	`Extracellular (Potential).`
`TRANSMEM`	`198 217`	`20`	`5 (Potential).`
`TOPO_DOM`	`218 237`	`20`	`Cytoplasmic (Potential).`
`TRANSMEM`	`238 258`	`21`	`6 (Potential).`
`TOPO_DOM`	`259 271`	`13`	`Extracellular (Potential).`
`TRANSMEM`	`272 292`	`21`	`7 (Potential).`
`TOPO_DOM`	`293 311`	`19`	`Cytoplasmic (Potential).`
`CARBOHYD`	`5 5`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`6 6`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`97 189`		`By similarity.`
`VARIANT`	`247 247`	`1`	`A -> V (in dbSNP:rs4482039 [NCBI]).`	`VAR_034260`

Sequence information

Length: 311 AA [This is the length of the unprocessed precursor]

Molecular weight: 34904 Da [This is the MW of the unprocessed precursor]

CRC64: 0E28F95C37960C3E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSGENNSSVT EFILAGLSEQ PELQLPLFLL FLGIYVVTVV GNLGMTTLIW LSSHLHTPMY 

        70         80         90        100        110        120 
YFLSSLSFID FCHSTVITPK MLVNFVTEKN IISYPECMTQ LYFFLVFAIA ECHMLAAMAY 

       130        140        150        160        170        180 
DRYMAICSPL LYSVIISNKA CFSLILGVYI IGLVCASVHT GCMFRVQFCK FDLINHYFCD 

       190        200        210        220        230        240 
LLPLLKLSCS SIYVNKLLIL CVGAFNILVP SLTILCSYIF IIASILHIRS TEGRSKAFST 

       250        260        270        280        290        300 
CSSHMLAVVI FFGSAAFMYL QPSSISSMDQ GKVSSVFYTI IVPMLNPLIY SLRNKDVHVS 

       310 
LKKMLQRRTL L

Q15617 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools