[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=10490618 [NCBI, ExPASy, EBI, Israel, Japan]
Das B.K.,
Xia L.,
Palandjian L.,
Gozani O.,
Chyung Y.,
Reed R.;
"Characterization of a protein complex containing spliceosomal proteins saps 49,130,145 and 155.";
Mol. Cell. Biol. 19:6796-6802(1999).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Bone marrow;
DOI=10.1093/dnares/1.1.27; PubMed=7584026 [NCBI, ExPASy, EBI, Israel, Japan]
Nomura N.,
Miyajima N.,
Sazuka T.,
Tanaka A.,
Kawarabayasi Y.,
Sato S.,
Nagase T.,
Seki N.,
Ishikawa K.,
Tabata S.;
"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.";
DNA Res. 1:27-35(1994).
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[3]
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SEQUENCE REVISION.
Nomura N.;
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
TISSUE=Lung, Skeletal muscle, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1003-1217 (ISOFORM 1).
TISSUE=Testis;
The German cDNA consortium;
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
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[6]
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MASS SPECTROMETRY, SUBCELLULAR LOCATION, INTERACTION WITH SUPT3H, AND INTERACTION WITH THE STAGA COMPLEX.
DOI=10.1128/MCB.21.20.6782-6795.2001; PubMed=11564863 [NCBI, ExPASy, EBI, Israel, Japan]
Martinez E.,
Palhan V.B.,
Tjernberg A.,
Lymar E.S.,
Gamper A.M.,
Kundu T.K.,
Chait B.T.,
Roeder R.G.;
"Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.";
Mol. Cell. Biol. 21:6782-6795(2001).
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[7]
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INTERACTION WITH TAF3.
DOI=10.1128/MCB.21.15.5109-5121.2001; PubMed=11438666 [NCBI, ExPASy, EBI, Israel, Japan]
Gangloff Y.G.,
Pointud J.-C.,
Thuault S.,
Carre L.,
Romier C.,
Muratoglu S.,
Brand M.,
Tora L.,
Couderc J.-L.,
Davidson I.;
"The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger.";
Mol. Cell. Biol. 21:5109-5121(2001).
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[8]
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SUBUNIT.
DOI=10.1093/emboj/cdf480; PubMed=12234937 [NCBI, ExPASy, EBI, Israel, Japan]
Will C.L.,
Urlaub H.,
Achsel T.,
Gentzel M.,
Wilm M.,
Luehrmann R.;
"Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.";
EMBO J. 21:4978-4988(2002).
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[9]
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IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
DOI=10.1017/S1355838202021088; PubMed=11991638 [NCBI, ExPASy, EBI, Israel, Japan]
Jurica M.S.,
Licklider L.J.,
Gygi S.P.,
Grigorieff N.,
Moore M.J.;
"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.";
RNA 8:426-439(2002).
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- FUNCTION: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
- SUBUNIT: Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Component of splicing factor SF3B which is composed of at least eight subunits; SF3B1/SAP155/SF3B155, SF3B2/SAP145/SF3B145, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B14A, PHF5A/SF3B14B, SF3B10 and SF3B125. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Interaction between SF3B3 and SF3B1 is tighter than the interaction between SF3B3 and SF3B2. Associates with the STAGA transcription coactivator-HAT complex. Interacts with SUPT3H.
- INTERACTION:
O15519:CFLAR; NbExp=1; IntAct=EBI-346977, EBI-514941;
P08631:HCK; NbExp=1; IntAct=EBI-346977, EBI-346340;
Q15287:RNPS1; NbExp=1; IntAct=EBI-346977, EBI-395959;
O75940:SMNDC1; NbExp=1; IntAct=EBI-346977, EBI-1052641;
P63162:SNRPN; NbExp=1; IntAct=EBI-346977, EBI-712493;
Q9UBN6:TNFRSF10D; NbExp=1; IntAct=EBI-346977, EBI-1044859;
- SUBCELLULAR LOCATION: Nucleus.
- ALTERNATIVE PRODUCTS:
3 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Isoform ID | Q15393-2 |
| Note: No experimental confirmation available. |
| Features which should be applied to build the isoform sequence: VSP_022978, VSP_022979. |
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| Name | 3 |
| Isoform ID | Q15393-3 |
| Note: No experimental confirmation available. |
| Features which should be applied to build the isoform sequence: VSP_022977. |
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- SIMILARITY: Belongs to the RSE1 family.
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