[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). TISSUE=Brain; DOI=10.1016/0169-328X(96)00110-6; PubMed=8840028 [NCBI, ExPASy, EBI, Israel, Japan] Makoff A., Pilling C., Harrington K., Emson P.; "Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS."; Brain Res. Mol. Brain Res. 40:165-170(1996).
[2]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). DOI=10.1016/S0028-3908(96)00176-1; PubMed=9144652 [NCBI, ExPASy, EBI, Israel, Japan] Flor P.J., Van Der Putten H., Ruegg D., Lukic S., Leonhardt T., Bence M., Sansig G., Knoepfel T., Kuhn R.; "A novel splice variant of a metabotropic glutamate receptor, human mGluR7b."; Neuropharmacology 36:153-159(1997).
[3]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). DOI=10.1016/S0169-328X(97)00277-5; PubMed=9473604 [NCBI, ExPASy, EBI, Israel, Japan] Wu S., Wright R.A., Rockey P.K., Burgett S.G., Arnold J.S., Rosteck P.R. Jr., Johnson B.G., Schoepp D.D., Belagaje R.M.; "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells."; Brain Res. Mol. Brain Res. 53:88-97(1998).
[4]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 5), AND TISSUE SPECIFICITY. DOI=10.1016/S0304-3940(02)00306-3; PubMed=12052533 [NCBI, ExPASy, EBI, Israel, Japan] Schulz H.L., Stoehr H., Weber B.H.F.; "Characterization of three novel isoforms of the metabotropic glutamate receptor 7 (GRM7)."; Neurosci. Lett. 326:37-40(2002).
[5]	VARIANT PHE-433. DOI=10.1016/S0920-9964(99)00235-2; PubMed=11163549 [NCBI, ExPASy, EBI, Israel, Japan] Bolonna A.A., Kerwin R.W., Munro J., Arranz M.J., Makoff A.J.; "Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia."; Schizophr. Res. 47:99-103(2001).

Comments

FUNCTION: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
SUBUNIT: Interacts with PICK1 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.

ALTERNATIVE PRODUCTS: 5 named isoforms [FASTA] produced by alternative splicing.

Name	1
Synonyms	GRM7_v1, mGluR7a
Isoform ID	Q14831-1
This is the isoform sequence displayed in this entry.

Name	2
Synonyms	GRM7_v2, mGluR7b
Isoform ID	Q14831-2
Features which should be applied to build the isoform sequence: VSP_015735.

Name	3
Synonyms	GRM7_v3
Isoform ID	Q14831-3
Features which should be applied to build the isoform sequence: VSP_015732.

Name	4
Synonyms	GRM7_v4
Isoform ID	Q14831-4
Features which should be applied to build the isoform sequence: VSP_015733.

Name	5
Synonyms	GRM7_v5
Isoform ID	Q14831-5
Features which should be applied to build the isoform sequence: VSP_015734.

TISSUE SPECIFICITY: Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4.
SIMILARITY: Belongs to the G-protein coupled receptor 3 family [view classification].

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X94552; CAA64245.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U92458; AAB51763.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF458052; AAM47557.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF458053; AAM47558.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF458054; AAM47559.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00292323; -.
IPI00335261; -.
IPI00376864; -.
IPI00651739; -.
IPI00745954; -.

RefSeq

NP_000835.1; -.
NP_870989.1; -.

UniGene

Hs.606393

3D structure databases

HSSP

P23385; 1EWK. [HSSP ENTRY / PDB]

SMR

Q14831; 40-511.

ModBase

Q14831.

Protein family/group databases

GPCRDB

Q14831; GRM7_HUMAN.

PTM databases

PhosphoSite

Q14831; -.

Organism-specific databases

GC03P006877; -.

HGNC:4599; GRM7.

604101; gene. [NCBI / EBI]

PharmGKB

PA28996; -.

Gene expression databases

Q14831; -.

Q14831; -.

HS_GRM7; -.

ENSG00000196277; Homo sapiens.

Ontologies

GO:0005887;	Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0045211;	Cellular component: postsynaptic membrane (traceable author statement from UniProtKB).
GO:0048787;	Cellular component: presynaptic active zone membrane (traceable author statement from UniProtKB).
GO:0004930;	Molecular function: G-protein coupled receptor activity (traceable author statement from UniProtKB).
GO:0008066;	Molecular function: glutamate receptor activity (traceable author statement from UniProtKB).
GO:0030165;	Molecular function: PDZ domain binding (traceable author statement from UniProtKB).
GO:0007186;	Biological process: G-protein coupled receptor protein signaling pathway (inferred from electronic annotation from UniProtKB-KW).
GO:0007194;	Biological process: negative regulation of adenylate cyclase activity (traceable author statement from ProtInc).
GO:0007608;	Biological process: sensory perception of smell (inferred from electronic annotation from UniProtKB-KW).
GO:0007268;	Biological process: synaptic transmission (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR001828; ANF_lig_bd_rcpt.
IPR000337; GPCR_3.
IPR017978; GPCR_3_C.
IPR017979; GPCR_3_CS.
IPR000162; GPCR_3_mtglu_rcpt.
IPR001883; GPCR_3_mtglu_rcpt_7.
IPR011500; GPCR_3_NCR.
Graphical view of domain structure.

Pfam

PF00003; 7tm_3; 1.
PF01094; ANF_receptor; 1.
PF07562; NCD3G; 1.
Pfam graphical view of domain structure.

PRINTS

PR00248; GPCRMGR.
PR01057; MTABOTROPC7R.
PR00593; MTABOTROPICR.

PROSITE

PS00979; G_PROTEIN_RECEP_F3_1; 1.
PS00980; G_PROTEIN_RECEP_F3_2; 1.
PS00981; G_PROTEIN_RECEP_F3_3; 1.
PS50259; G_PROTEIN_RECEP_F3_4; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

Q14831; -.

Genome annotation databases

Ensembl

ENSG00000196277; Homo sapiens. [Contig view]

GeneID

2917; -.

KEGG

hsa:2917; -.

Phylogenomic databases

HOVERGEN

Q14831; -.

Other

DrugBank

DB00142; L-Glutamic Acid.

11563; -.

GRM7; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; Olfaction; Phosphoprotein; Polymorphism; Receptor; Sensory transduction; Signal; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 34`	`34`	`Potential.`
`CHAIN`	`35 915`	`881`	`Metabotropic glutamate receptor 7.`	`PRO_0000012938`
`TOPO_DOM`	`35 590`	`556`	`Extracellular (Potential).`
`TRANSMEM`	`591 615`	`25`	`1 (Potential).`
`TOPO_DOM`	`616 627`	`12`	`Cytoplasmic (Potential).`
`TRANSMEM`	`628 648`	`21`	`2 (Potential).`
`TOPO_DOM`	`649 654`	`6`	`Extracellular (Potential).`
`TRANSMEM`	`655 675`	`21`	`3 (Potential).`
`TOPO_DOM`	`676 702`	`27`	`Cytoplasmic (Potential).`
`TRANSMEM`	`703 723`	`21`	`4 (Potential).`
`TOPO_DOM`	`724 753`	`30`	`Extracellular (Potential).`
`TRANSMEM`	`754 775`	`22`	`5 (Potential).`
`TOPO_DOM`	`776 788`	`13`	`Cytoplasmic (Potential).`
`TRANSMEM`	`789 810`	`22`	`6 (Potential).`
`TOPO_DOM`	`811 825`	`15`	`Extracellular (Potential).`
`TRANSMEM`	`826 850`	`25`	`7 (Potential).`
`TOPO_DOM`	`851 915`	`65`	`Cytoplasmic (Potential).`
`MOD_RES`	`900 900`		`Phosphoserine (By similarity).`
`CARBOHYD`	`98 98`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`458 458`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`486 486`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`572 572`		`N-linked (GlcNAc...) (Potential).`
`VAR_SEQ`	`900 915`		`SPAAKKKYVSYNNLVI -> NCIPPVRKSVQKSVTWYTIPPTV (in isoform 2).`	`VSP_015735`
`VAR_SEQ`	`900 915`		`SPAAKKKYVSYNNLVI -> NFFFGCTVELGLHFKLTFSRNQSNL (in isoform 3).`	`VSP_015732`
`VAR_SEQ`	`900 915`		`SPAAKKKYVSYNNLVI -> ITSEDLSLHKED (in isoform 4).`	`VSP_015733`
`VAR_SEQ`	`900 915`		`SPAAKKKYVSYNNLVI -> SEKCNCY (in isoform 5).`	`VSP_015734`
`VARIANT`	`433 433`	`1`	`Y -> F (in dbSNP:rs2229902 [NCBI]).`	`VAR_003584`
`VARIANT`	`495 495`	`1`	`I -> V (in dbSNP:rs7634846 [NCBI]).`	`VAR_049276`
`VARIANT`	`745 745`	`1`	`G -> E (in dbSNP:rs1485174 [NCBI]).`	`VAR_049277`

Sequence information

Length: 915 AA [This is the length of the unprocessed precursor]

Molecular weight: 102251 Da [This is the MW of the unprocessed precursor]

CRC64: CFF94E06BF7F4919 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MVQLRKLLRV LTLMKFPCCV LEVLLCALAA AARGQEMYAP HSIRIEGDVT LGGLFPVHAK 

        70         80         90        100        110        120 
GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT LGARILDTCS RDTYALEQSL 

       130        140        150        160        170        180 
TFVQALIQKD TSDVRCTNGE PPVFVKPEKV VGVIGASGSS VSIMVANILR LFQIPQISYA 

       190        200        210        220        230        240 
STAPELSDDR RYDFFSRVVP PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ 

       250        260        270        280        290        300 
ISKEAGGLCI AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 

       310        320        330        340        350        360 
RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF TSRTLENNRR 

       370        380        390        400        410        420 
NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS NYEQEGKVQF VIDAVYAMAH 

       430        440        450        460        470        480 
ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF 

       490        500        510        520        530        540 
QYQTTNTSNP GYRLIGQWTD ELQLNIEDMQ WGKGVREIPA SVCTLPCKPG QRKKTQKGTP 

       550        560        570        580        590        600 
CCWTCEPCDG YQYQFDEMTC QHCPYDQRPN ENRTGCQDIP IIKLEWHSPW AVIPVFLAML 

       610        620        630        640        650        660 
GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP DVAVCSFRRV 

       670        680        690        700        710        720 
FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT SQLAITSSLI SVQLLGVFIW 

       730        740        750        760        770        780 
FGVDPPNIII DYDEHKTMNP EQARGVLKCD ITDLQIICSL GYSILLMVTC TVYAIKTRGV 

       790        800        810        820        830        840 
PENFNEAKPI GFTMYTTCIV WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML 

       850        860        870        880        890        900 
YMPKVYIIIF HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS 

       910 
PAAKKKYVSY NNLVI

Q14831 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools