[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT). PubMed=8202485 [NCBI, ExPASy, EBI, Israel, Japan] Bailly P., Hermand P., Callebaut I., Sonneborn H.H., Khamlichi S., Mornon J.-P., Cartron J.-P.; "The LW blood group glycoprotein is homologous to intercellular adhesion molecules."; Proc. Natl. Acad. Sci. U.S.A. 91:5306-5310(1994).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM LONG). PubMed=8639917 [NCBI, ExPASy, EBI, Israel, Japan] Hermand P., le Pennec P.Y., Rouger P., Cartron J.-P., Bailly P.; "Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes."; Blood 87:2962-2967(1996).
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LEU-208. SeattleSNPs program for genomic applications; Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG). TISSUE=Lung; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[5]	NUCLEOTIDE SEQUENCE [MRNA] OF 1-130, AND VARIANT BLOOD GROUP LW(B) ARG-100. PubMed=7632968 [NCBI, ExPASy, EBI, Israel, Japan] Hermand P., Gane P., Mattei M.-G., Sistonen P., Cartron J.-P., Bailly P.; "Molecular basis and expression of the LWa/LWb blood group polymorphism."; Blood 86:1590-1594(1995).
[6]	FUNCTION. DOI=10.1182/blood.V98.2.458; PubMed=11435317 [NCBI, ExPASy, EBI, Israel, Japan] Spring F.A., Parsons S.F., Ortlepp S., Olsson M.L., Sessions R., Brady R.L., Anstee D.J.; "Intercellular adhesion molecule-4 binds alpha(4)beta(1) and alpha(V)-family integrins through novel integrin-binding mechanisms."; Blood 98:458-466(2001).

Comments

FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.
SUBCELLULAR LOCATION: Isoform Long: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform Short: Secreted.
ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name Long

Isoform ID Q14773-1

This is the isoform sequence displayed in this entry.

Name Short

Isoform ID Q14773-2

Features which should be applied to build the isoform sequence: VSP_002519.
TISSUE SPECIFICITY: Erythrocytes.
PTM: N- and O-glycosylated.
POLYMORPHISM: Responsible for the Landsteiner-Wiener blood group system. The molecular basis of the LW(A)=LW5/LW(B)=LW7 blood group antigens is a single variation in position 100; Gln-100 corresponds to LW(A) and Arg-100 to LW(B).
SIMILARITY: Belongs to the immunoglobulin superfamily. ICAM family.
SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
WEB RESOURCE: Name=BGMUT; Note=Blood group antigen gene mutation database"; URL="http://www.ncbi.nlm.nih.gov/projects/mhc/xslcgi.fcgi?cmd=bgmut/systems_info&system=lw";.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/icam4/";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L27671; AAA59538.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
L27670; AAA59537.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X93093; CAA63646.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
DQ011692; AAY16986.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC029364; AAH29364.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
S78852; AAB35046.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

I52612; I52612.
I59300; I59300.
I80159; I80159.

RefSeq

NP_001535.1; -.
NP_071772.1; -.

UniGene

Hs.699174

3D structure databases

HSSP

P05362; 1IC1. [HSSP ENTRY / PDB]

ModBase

Q14773.

Protein-protein interaction databases

IntAct

Q14773; -.

Enzyme and pathway databases

Reactome

REACT_6900; Signaling in Immune System.

Organism-specific databases

HIX0014739; -.

HGNC:5347; ICAM4.

ICAM4; Homo sapiens.

111250; gene+phenotype. [NCBI / EBI]

PharmGKB

PA29595; -.

GeneCards

Q14773.

Gene expression databases

CleanEx

HS_ICAM4; -.

GermOnline

ENSG00000105371; Homo sapiens.

Ontologies

GO:0016021;	Cellular component: integral to membrane (traceable author statement from ProtInc).
GO:0005886;	Cellular component: plasma membrane (traceable author statement from ProtInc).
GO:0005178;	Molecular function: integrin binding (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR013768; ICAM_N.
IPR003987; ICAM_VCAM_N.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.10; Ig-like_fold; 2.

Pfam

PF03921; ICAM_N; 1.
Pfam graphical view of domain structure.

PRINTS

PR01472; ICAMVCAM1.

PROSITE

PS50835; IG_LIKE; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q14773.

Genome annotation databases

Ensembl

ENSG00000105371; Homo sapiens. [Contig view]

GeneID

3386; -.

Phylogenomic databases

HOVERGEN

Q14773; -.

Other

ICAM4; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Blood group antigen; Cell adhesion; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Repeat; Secreted; Signal; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 22`	`22`	`Potential.`
`CHAIN`	`23 271`	`249`	`Intercellular adhesion molecule 4.`	`PRO_0000014796`
`TOPO_DOM`	`23 240`	`218`	`Extracellular (Potential).`
`TRANSMEM`	`241 261`	`21`	`Potential.`
`TOPO_DOM`	`262 271`	`10`	`Cytoplasmic (Potential).`
`DOMAIN`	`62 124`	`63`	`Ig-like C2-type 1.`
`DOMAIN`	`146 217`	`72`	`Ig-like C2-type 2.`
`CARBOHYD`	`68 68`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`78 78`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`190 190`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`223 223`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`69 117`		`By similarity.`
`DISULFID`	`153 210`		`By similarity.`
`VAR_SEQ`	`233 271`		`AWSPAPTALASGSIAALVGILLTVGAAYLCKCLAMKSQA -> GEAPL (in isoform Short).`	`VSP_002519`
`VARIANT`	`100 100`	`1`	`Q -> R (in LW(B)).`	`VAR_003912`
`VARIANT`	`208 208`	`1`	`V -> L.`	`VAR_038721`
`CONFLICT`	`14 29`		`AAAYPGVGSALGRRTK -> RPPTRELGARWDAGL (in Ref. 1; AAA59538/AAA59537).`

Sequence information

Length: 271 AA [This is the length of the unprocessed precursor]

Molecular weight: 29265 Da [This is the MW of the unprocessed precursor]

CRC64: 2F6BC8BABD79E615 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGSLFPLSLL FFLAAAYPGV GSALGRRTKR AQSPKGSPLA PSGTSVPFWV RMSPEFVAVQ 

        70         80         90        100        110        120 
PGKSVQLNCS NSCPQPQNSS LRTPLRQGKT LRGPGWVSYQ LLDVRAWSSL AHCLVTCAGK 

       130        140        150        160        170        180 
TRWATSRITA YKPPHSVILE PPVLKGRKYT LRCHVTQVFP VGYLVVTLRH GSRVIYSESL 

       190        200        210        220        230        240 
ERFTGLDLAN VTLTYEFAAG PRDFWQPVIC HARLNLDGLV VRNSSAPITL MLAWSPAPTA 

       250        260        270 
LASGSIAALV GILLTVGAAY LCKCLAMKSQ A

Q14773 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools