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UniProtKB/Swiss-Prot entry Q14576

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ELAV3_HUMAN
Primary accession number Q14576
Secondary accession numbers Q16135 Q96CL8 Q96QS9
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on May 27, 2002 (Sequence version 3)
Annotations were last modified on    June 16, 2009 (Entry version 83)
Name and origin of the protein
Protein name ELAV-like protein 3
Synonyms Hu-antigen C
HuC
Paraneoplastic cerebellar degeneration-associated antigen
Paraneoplastic limbic encephalitis antigen 21
Gene name
Name: ELAVL3
Synonyms: HUC, PLE21
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Brain;
Manley T., Furneaux H.M.;
Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Zhang B., Yuan J.G., Qiang B.Q.;
"Isolation of HuC cDNA.";
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
 NUCLEOTIDE SEQUENCE [MRNA] OF 9-367 (ISOFORM 2).
TISSUE=Hippocampus;
DOI=10.1006/bbrc.1994.1358; PubMed=7511893 [NCBI, ExPASy, EBI, Israel, Japan]
Sakai K., Gofuku M., Kitagawa Y., Ogasawara T., Hirose G., Yamazaki M., Koh C.S., Yanagisawa N., Steinman L.;
"A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma.";
Biochem. Biophys. Res. Commun. 199:1200-1208(1994).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L26405; AAA58677.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY036909; AAK67714.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC014144; AAH14144.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D26158; BAA21838.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00031552; -.
IPI00140449; -.
RefSeq NP_001411.2; -.
NP_115657.2; -.
UniGene Hs.1701
3D structure databases
HSSP Q60900; 1D8Z. [HSSP ENTRY / PDB]
SMR Q14576; 36-208.
ModBase Q14576.
Protein-protein interaction databases
IntAct Q14576; 1.
PTM databases
PhosphoSite Q14576; -.
Organism-specific databases
GeneCards GC19M011426; -.
H-InvDB HIX0014771; -.
HGNC HGNC:3314; ELAVL3.
GenAtlas ELAVL3.
HPA CAB013066; -.
MIM 603458; gene. [NCBI / EBI]
PharmGKB PA27742; -.
Gene expression databases
ArrayExpress Q14576; -.
Bgee Q14576; -.
CleanEx HS_ELAVL3; -.
GermOnline ENSG00000196361; Homo sapiens.
Ontologies
GO
GO:0000166; Molecular function: nucleotide binding (inferred from electronic annotation from InterPro).
GO:0003723; Molecular function: RNA binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030154; Biological process: cell differentiation (inferred from electronic annotation from UniProtKB-KW).
GO:0007399; Biological process: nervous system development (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR012677; a_b_plait_nuc_bd.
IPR006548; ELAD_HUD_SF.
IPR002343; Hud_Sxl_RNA.
IPR000504; RRM_RNP1.
Graphical view of domain structure.
Gene3D G3DSA:3.30.70.330; a_b_plait_nuc_bd; 3.
Pfam PF00076; RRM_1; 3.
Pfam graphical view of domain structure.
PRINTS PR00961; HUDSXLRNA.
SMART SM00360; RRM; 3.
SMART graphical view of domain structure.
TIGRFAMs TIGR01661; ELAV_HUD_SF; 1.
PROSITE PS50102; RRM; 3.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q14576; -.
Genome annotation databases
Ensembl ENSG00000196361; Homo sapiens. [Contig view]
GeneID 1995; -.
KEGG hsa:1995; -.
Phylogenomic databases
HOGENOM Q14576; -.
HOVERGEN Q14576; -.
OMA Q14576; ISTMETQ.
Other
NextBio 8067; -.
SOURCE ELAVL3; Homo sapiens.
ProtoNet Q14576.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Developmental protein; Differentiation; Neurogenesis; Repeat; RNA-binding.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   367  367     ELAV-like protein 3. PRO_0000081581
DOMAIN   39   117  79     RRM 1. 
DOMAIN   125   205  81     RRM 2. 
DOMAIN   284   362  79     RRM 3. 
VAR_SEQ   251   257        Missing (in isoform 2). VSP_005789
CONFLICT   20    25        PALPNG -> RPAQR (in Ref. 4; BAA21838). 
CONFLICT   78    79        QS -> RD (in Ref. 1 and 2). 
CONFLICT   88    88        S -> P (in Ref. 1 and 2). 
CONFLICT   195   195        A -> R (in Ref. 4; BAA21838). 
CONFLICT   248   248        G -> A (in Ref. 4). 
CONFLICT   282   282        Missing (in Ref. 1 and 4). 
CONFLICT   295   297        ADE -> PDQ (in Ref. 4; BAA21838). 
CONFLICT   330   330        V -> M (in Ref. 4; BAA21838). 
CONFLICT   351   351        G -> A (in Ref. 1; AAA58677). 
CONFLICT   352   352        E -> Q (in Ref. 4; BAA21838). 
Sequence information
Length: 367 AA [This is the length of the unprocessed precursor] Molecular weight: 39547 Da [This is the MW of the unprocessed precursor] CRC64: 03FB3BD4D112B326 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM TQDEFKSLFG 

        70         80         90        100        110        120 
SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL NGLKLQTKTI KVSYARPSSA 

       130        140        150        160        170        180 
SIRDANLYVS GLPKTMSQKE MEQLFSQYGR IITSRILVDQ VTGVSRGVGF IRFDKRIEAE 

       190        200        210        220        230        240 
EAIKGLNGQK PLGAAEPITV KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD 

       250        260        270        280        290        300 
NLLNMAYGVK SPLSLIARFS PIAIDGMSGL AGVGLSGGAA GAGWCIFVYN LSPEADESVL 

       310        320        330        340        350        360 
WQLFGPFGAV TNVKVIRDFT TNKCKGFGFV TMTNYDEAAM AIASLNGYRL GERVLQVSFK 


TSKQHKA
Q14576 in FASTA format

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