[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Brain;
DOI=10.1038/376737a0; PubMed=7544443 [NCBI, ExPASy, EBI, Israel, Japan]
Lev S.,
Moreno H.,
Martinez R.,
Canoll P.,
Peles E.,
Musacchio J.M.,
Plowman G.D.,
Rudy B.,
Schlessinger J.;
"Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions.";
Nature 376:737-745(1995).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Hippocampus;
DOI=10.1006/geno.1996.0149; PubMed=8838818 [NCBI, ExPASy, EBI, Israel, Japan]
Herzog H.,
Nicholl J.,
Hort Y.J.,
Sutherland G.R.,
Shine J.;
"Molecular cloning and assignment of FAK2, a novel human focal adhesion kinase, to 8p11.2-p22 by nonisotopic in situ hybridization.";
Genomics 32:484-486(1996).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Hippocampus;
DOI=10.1074/jbc.270.36.21206; PubMed=7673154 [NCBI, ExPASy, EBI, Israel, Japan]
Sasaki H.,
Nagura K.,
Ishino M.,
Tobioka H.,
Kotani K.,
Sasaki T.;
"Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily.";
J. Biol. Chem. 270:21206-21219(1995).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
DOI=10.1074/jbc.270.46.27742; PubMed=7499242 [NCBI, ExPASy, EBI, Israel, Japan]
Avraham S.,
London R.,
Fu Y.,
Ota S.,
Hiregowdara D.,
Li J.,
Jiang S.,
Pasztor L.M.,
White R.A.,
Groopman J.E.,
Avraham H.;
"Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain.";
J. Biol. Chem. 270:27742-27751(1995).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Monocyte;
DOI=10.1074/jbc.273.16.9361; PubMed=9545257 [NCBI, ExPASy, EBI, Israel, Japan]
Li X.,
Hunter D.,
Morris J.,
Haskill J.S.,
Earp H.S.;
"A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal.";
J. Biol. Chem. 273:9361-9364(1998).
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04406; PubMed=16421571 [NCBI, ExPASy, EBI, Israel, Japan]
Nusbaum C.,
Mikkelsen T.S.,
Zody M.C.,
Asakawa S.,
Taudien S.,
Garber M.,
Kodira C.D.,
Schueler M.G.,
Shimizu A.,
Whittaker C.A.,
Chang J.L.,
Cuomo C.A.,
Dewar K.,
FitzGerald M.G.,
Yang X.,
Allen N.R.,
Anderson S.,
Asakawa T.,
Blechschmidt K., ![]()
Bloom T.,
Borowsky M.L.,
Butler J.,
Cook A.,
Corum B.,
DeArellano K.,
DeCaprio D.,
Dooley K.T.,
Dorris L. III,
Engels R.,
Gloeckner G.,
Hafez N.,
Hagopian D.S.,
Hall J.L.,
Ishikawa S.K.,
Jaffe D.B.,
Kamat A.,
Kudoh J.,
Lehmann R.,
Lokitsang T.,
Macdonald P.,
Major J.E.,
Matthews C.D.,
Mauceli E.,
Menzel U.,
Mihalev A.H.,
Minoshima S.,
Murayama Y.,
Naylor J.W.,
Nicol R.,
Nguyen C.,
O'Leary S.B.,
O'Neill K.,
Parker S.C.J.,
Polley A.,
Raymond C.K.,
Reichwald K.,
Rodriguez J.,
Sasaki T.,
Schilhabel M.,
Siddiqui R.,
Smith C.L.,
Sneddon T.P.,
Talamas J.A.,
Tenzin P.,
Topham K.,
Venkataraman V.,
Wen G.,
Yamazaki S.,
Young S.K.,
Zeng Q.,
Zimmer A.R.,
Rosenthal A.,
Birren B.W.,
Platzer M.,
Shimizu N.,
Lander E.S.;
"DNA sequence and analysis of human chromosome 8.";
Nature 439:331-335(2006).
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[7]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Lymph;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[8]
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INTERACTION WITH TGFB1I1.
DOI=10.1074/jbc.273.2.1003; PubMed=9422762 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuya M.,
Sasaki H.,
Aoto H.,
Mitaka T.,
Nagura K.,
Ohba T.,
Ishino M.,
Takahashi S.,
Suzuki R.,
Sasaki T.;
"Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions.";
J. Biol. Chem. 273:1003-1014(1998).
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[9]
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INTERACTION WITH ASAP2.
PubMed=10022920 [NCBI, ExPASy, EBI, Israel, Japan]
Andreev J.,
Simon J.-P.,
Sabatini D.D.,
Kam J.,
Plowman G.,
Randazzo P.A.,
Schlessinger J.;
"Identification of a new Pyk2 target protein with Arf-GAP activity.";
Mol. Cell. Biol. 19:2338-2350(1999).
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[10]
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PHOSPHORYLATION AT TYR-402, MUTAGENESIS OF PRO-859, AND INTERACTION WITH NEPHROCYSTIN.
DOI=10.1073/pnas.171269898; PubMed=11493697 [NCBI, ExPASy, EBI, Israel, Japan]
Benzing T.,
Gerke P.,
Hoepker K.,
Hildebrandt F.,
Kim E.,
Walz G.;
"Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2.";
Proc. Natl. Acad. Sci. U.S.A. 98:9784-9789(2001).
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[11]
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INTERACTION WITH SKAP2, SUBCELLULAR LOCATION, AND FUNCTION.
DOI=10.1074/jbc.M213217200; PubMed=12893833 [NCBI, ExPASy, EBI, Israel, Japan]
Takahashi T.,
Yamashita H.,
Nagano Y.,
Nakamura T.,
Ohmori H.,
Avraham H.,
Avraham S.,
Yasuda M.,
Matsumoto M.;
"Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation.";
J. Biol. Chem. 278:42225-42233(2003).
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[12]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-579 AND TYR-580, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.2436191100; PubMed=12522270 [NCBI, ExPASy, EBI, Israel, Japan]
Salomon A.R.,
Ficarro S.B.,
Brill L.M.,
Brinker A.,
Phung Q.T.,
Ericson C.,
Sauer K.,
Brock A.,
Horn D.M.,
Schultz P.G.,
Peters E.C.;
"Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.";
Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003).
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[13]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-579 AND TYR-580, AND MASS SPECTROMETRY.
DOI=10.1016/j.cell.2007.11.025; PubMed=18083107 [NCBI, ExPASy, EBI, Israel, Japan]
Rikova K.,
Guo A.,
Zeng Q.,
Possemato A.,
Yu J.,
Haack H.,
Nardone J.,
Lee K.,
Reeves C.,
Li Y.,
Hu Y.,
Tan Z.,
Stokes M.,
Sullivan L.,
Mitchell J.,
Wetzel R.,
Macneill J.,
Ren J.M.,
Yuan J., ![]()
Bakalarski C.E.,
Villen J.,
Kornhauser J.M.,
Smith B.,
Li D.,
Zhou X.,
Gygi S.P.,
Gu T.-L.,
Polakiewicz R.D.,
Rush J.,
Comb M.J.;
"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.";
Cell 131:1190-1203(2007).
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[14]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375 AND TYR-579, AND MASS SPECTROMETRY.
DOI=10.1074/mcp.T600062-MCP200; PubMed=17192257 [NCBI, ExPASy, EBI, Israel, Japan]
Wissing J.,
Jaensch L.,
Nimtz M.,
Dieterich G.,
Hornberger R.,
Keri G.,
Wehland J.,
Daub H.;
"Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.";
Mol. Cell. Proteomics 6:537-547(2007).
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[15]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375, AND MASS SPECTROMETRY.
TISSUE=Platelet;
DOI=10.1021/pr0704130; PubMed=18088087 [NCBI, ExPASy, EBI, Israel, Japan]
Zahedi R.P.,
Lewandrowski U.,
Wiesner J.,
Wortelkamp S.,
Moebius J.,
Schuetz C.,
Walter U.,
Gambaryan S.,
Sickmann A.;
"Phosphoproteome of resting human platelets.";
J. Proteome Res. 7:526-534(2008).
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[16]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375; SER-399; SER-758; SER-762; THR-765; SER-839 AND THR-842, AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H.,
Olsen J.V.,
Bairlein M.,
Gnad F.,
Oppermann F.S.,
Korner R.,
Greff Z.,
Keri G.,
Stemmann O.,
Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
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[17]
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IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J.,
Superti-Furga G.,
Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
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[18]
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VARIANTS [LARGE SCALE ANALYSIS] GLU-359; HIS-698; PRO-808; THR-838 AND LYS-970.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C.,
Stephens P.,
Smith R.,
Dalgliesh G.L.,
Hunter C.,
Bignell G.,
Davies H.,
Teague J.,
Butler A.,
Stevens C.,
Edkins S.,
O'Meara S.,
Vastrik I.,
Schmidt E.E.,
Avis T.,
Barthorpe S.,
Bhamra G.,
Buck G.,
Choudhury B., ![]()
Clements J.,
Cole J.,
Dicks E.,
Forbes S.,
Gray K.,
Halliday K.,
Harrison R.,
Hills K.,
Hinton J.,
Jenkinson A.,
Jones D.,
Menzies A.,
Mironenko T.,
Perry J.,
Raine K.,
Richardson D.,
Shepherd R.,
Small A.,
Tofts C.,
Varian J.,
Webb T.,
West S.,
Widaa S.,
Yates A.,
Cahill D.P.,
Louis D.N.,
Goldstraw P.,
Nicholson A.G.,
Brasseur F.,
Looijenga L.,
Weber B.L.,
Chiew Y.-E.,
DeFazio A.,
Greaves M.F.,
Green A.R.,
Campbell P.,
Birney E.,
Easton D.F.,
Chenevix-Trench G.,
Tan M.-H.,
Khoo S.K.,
Teh B.T.,
Yuen S.T.,
Leung S.Y.,
Wooster R.,
Futreal P.A.,
Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
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