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UniProtKB/Swiss-Prot entry Q13795


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ARFRP_HUMAN
Primary accession number Q13795
Secondary accession number Q6IBQ0
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 82)
Name and origin of the protein
Protein name ADP-ribosylation factor-related protein 1
Synonyms ARF-related protein 1
ARP
Gene name
Name: ARFRP1
Synonyms: ARP1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
DOI=10.1074/jbc.270.51.30657; PubMed=8530503 [NCBI, ExPASy, EBI, Israel, Japan]
Schuermann A., Massmann S., Joost H.-G.;
"ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors.";
J. Biol. Chem. 270:30657-30663(1995).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1073/pnas.97.3.1230; PubMed=10655513 [NCBI, ExPASy, EBI, Israel, Japan]
Bai C., Connolly B., Metzker M.L., Hilliard C.A., Liu X., Sandig V., Soderman A., Galloway S.M., Liu Q., Austin C.P., Caskey C.T.;
"Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster.";
Proc. Natl. Acad. Sci. U.S.A. 97:1230-1235(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/414865a; PubMed=11780052 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, and Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
SUBCELLULAR LOCATION, AND INTERACTION WITH SYS1.
DOI=10.1038/ncb1120; PubMed=15077113 [NCBI, ExPASy, EBI, Israel, Japan]
Behnia R., Panic B., Whyte J.R.C., Munro S.;
"Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p.";
Nat. Cell Biol. 6:405-413(2004).
[8]
VARIANT [LARGE SCALE ANALYSIS] VAL-108.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X91504; CAA62804.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF217796; AAF35246.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR456752; CAG33033.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT019624; AAV38430.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT019663; AAV38469.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL121845; CAC03669.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC092480; AAH92480.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC093967; AAH93967.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00015178; -.
RefSeq NP_001128230.1; -.
NP_003215.1; -.
UniGene Hs.389277
3D structure databases
HSSP Q9WUL7; 1FZQ. [HSSP ENTRY / PDB]
ModBase Q13795.
Organism-specific databases
GeneCards GC20M061800; -.
H-InvDB HIX0016008; -.
HIX0080492; -.
HGNC HGNC:662; ARFRP1.
GenAtlas ARFRP1.
MIM 604699; gene. [NCBI / EBI]
PharmGKB PA24946; -.
Gene expression databases
ArrayExpress Q13795; -.
Bgee Q13795; -.
CleanEx HS_ARFRP1; -.
GermOnline ENSG00000101246; Homo sapiens.
Ontologies
GO
GO:0005794; Cellular component: Golgi apparatus (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005624; Cellular component: membrane fraction (traceable author statement from ProtInc).
GO:0005525; Molecular function: GTP binding (inferred from electronic annotation from UniProtKB-KW).
GO:0003924; Molecular function: GTPase activity (traceable author statement from ProtInc).
GO:0007264; Biological process: small GTPase mediated signal transduction (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR006688; ARF.
IPR006689; ARF/SAR.
IPR001806; Ras_GTPase.
IPR005225; Small_GTP_bd.
Graphical view of domain structure.
PANTHER PTHR11711; ARF/SAR; 1.
Pfam PF00025; Arf; 1.
Pfam graphical view of domain structure.
PRINTS PR00449; RASTRNSFRMNG.
SMART SM00177; ARF; 1.
SMART graphical view of domain structure.
TIGRFAMs TIGR00231; small_GTP; 1.
PROSITE PS51417; ARF; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q13795; -.
Genome annotation databases
Ensembl ENSG00000101246; Homo sapiens. [Contig view]
GeneID 10139; -.
Phylogenomic databases
HOGENOM Q13795; -.
HOVERGEN Q13795; -.
OMA Q13795; SESKRAF.
Other
NextBio 38359; -.
SOURCE ARFRP1; Homo sapiens.
ProtoNet Q13795.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Golgi apparatus; GTP-binding; Nucleotide-binding; Polymorphism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   201  201     ADP-ribosylation factor-related protein 1. PRO_0000207487
NP_BIND   24    31  8     GTP (By similarity). 
NP_BIND   75    79  5     GTP (By similarity). 
NP_BIND   134   137  4     GTP (By similarity). 
VARIANT   108   108  1     L -> V (in a breast cancer sample; somatic mutation). VAR_036559 
Sequence information
Length: 201 AA [This is the length of the unprocessed precursor] Molecular weight: 22614 Da [This is the MW of the unprocessed precursor] CRC64: 8A75CF7A3B268158 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MYTLLSGLYK YMFQKDEYCI LILGLDNAGK TTFLEQSKTR FNKNYKGMSL SKITTTVGLN 

        70         80         90        100        110        120 
IGTVDVGKAR LMFWDLGGQE ELQSLWDKYY AECHGVIYVI DSTDEERLAE SKQAFEKVVT 

       130        140        150        160        170        180 
SEALCGVPVL VLANKQDVET CLSIPDIKTA FSDCTSKIGR RDCLTQACSA LTGKGVREGI 

       190        200 
EWMVKCVVRN VHRPPRQRDI T 

Q13795 in FASTA format

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