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UniProtKB/Swiss-Prot entry Q13451


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FKBP5_HUMAN
Primary accession number Q13451
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on July 15, 1998 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 84)
Name and origin of the protein
Protein name FK506-binding protein 5
Synonyms EC 5.2.1.8
Peptidyl-prolyl cis-trans isomerase
PPIase
Rotamase
51 kDa FK506-binding protein
FKBP-51
54 kDa progesterone receptor-associated immunophilin
FKBP54
P54
FF1 antigen
HSP90-binding immunophilin
Androgen-regulated protein 6
Gene name
Name: FKBP5
Synonyms: AIG6, FKBP51
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Thymus;
DOI=10.1006/bbrc.1997.6307; PubMed=9125197 [NCBI, ExPASy, EBI, Israel, Japan]
Baughman G., Wiederrecht G.J., Chang F., Martin M.M., Bourgeois S.;
"Tissue distribution and abundance of human FKBP51, an FK506-binding protein that can mediate calcineurin inhibition.";
Biochem. Biophys. Res. Commun. 232:437-443(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Zhang J.S., Smith D.I.;
"Identification of AIG6 as an androgen response gene in human prostate cancer cell line LNCaP.";
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 9-457.
PubMed=9001212 [NCBI, ExPASy, EBI, Israel, Japan]
Nair S.C., Rimerman R.A., Toran E.J., Chen S., Prapapanich V., Butts R.N., Smith D.F.;
"Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor.";
Mol. Cell. Biol. 17:594-603(1997).
[5]
CHARACTERIZATION.
PubMed=7693698 [NCBI, ExPASy, EBI, Israel, Japan]
Smith D.F., Albers M.W., Schreiber S.L., Leach K.L., Deibel M.R. Jr.;
"FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts.";
J. Biol. Chem. 268:24270-24273(1993).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0404720101; PubMed=15302935 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-445, AND MASS SPECTROMETRY.
DOI=10.1126/science.1140321; PubMed=17525332 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.";
Science 316:1160-1166(2007).
[8]
X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
DOI=10.1073/pnas.0231020100; PubMed=12538866 [NCBI, ExPASy, EBI, Israel, Japan]
Sinars C.R., Cheung-Flynn J., Rimerman R.A., Scammell J.G., Smith D.F., Clardy J.;
"Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes.";
Proc. Natl. Acad. Sci. U.S.A. 100:868-873(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U71321; AAC51189.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF194172; AAL54872.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC042605; AAH42605.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U42031; AAA86245.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JC5422; JC5422.
RefSeq NP_004108.1; -.
UniGene Hs.407190
3D structure databases
PDB
1KT0; X-ray; 2.70 A; A=1-457.[ExPASy / RCSB / EBI]
PDBsum 1KT0; -.
ModBase Q13451.
Protein-protein interaction databases
DIP DIP:27597N; -.
IntAct Q13451; -.
PTM databases
PhosphoSite Q13451; -.
Organism-specific databases
H-InvDB HIX0005809; -.
HGNC HGNC:3721; FKBP5.
GenAtlas FKBP5.
HPA CAB009315; -.
MIM 602623; gene. [NCBI / EBI]
PharmGKB PA28162; -.
GeneCards Q13451.
Gene expression databases
ArrayExpress Q13451; -.
CleanEx HS_FKBP5; -.
GermOnline ENSG00000096060; Homo sapiens.
Ontologies
GO
GO:0005528; Molecular function: FK506 binding (traceable author statement from ProtInc).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from UniProtKB).
GO:0006457; Biological process: protein folding (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR001179; PPIase_FKBP.
IPR001440; TPR-1.
IPR011990; TPR-like_helical.
IPR013026; TPR_region.
Graphical view of domain structure.
Gene3D G3DSA:1.25.40.10; TPR-like_helical; 1.
PANTHER PTHR10516; PPIase_FKBP; 1.
Pfam PF00254; FKBP_C; 2.
PF00515; TPR_1; 2.
Pfam graphical view of domain structure.
PROSITE PS50059; FKBP_PPIASE; 2.
PS50005; TPR; 3.
PS50293; TPR_REGION; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q13451.
Genome annotation databases
Ensembl ENSG00000096060; Homo sapiens. [Contig view]
GeneID 2289; -.
KEGG hsa:2289; -.
Phylogenomic databases
HOGENOM Q13451; -.
HOVERGEN Q13451; -.
Other
SOURCE FKBP5; Homo sapiens.
ProtoNet Q13451.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Chaperone; Cytoplasm; Isomerase; Nucleus; Phosphoprotein; Repeat; Rotamase; TPR repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   457  457     FK506-binding protein 5. PRO_0000075324
DOMAIN   42   130  89     PPIase FKBP-type 1. 
DOMAIN   157   243  87     PPIase FKBP-type 2. 
REPEAT   268   301  34     TPR 1. 
REPEAT   317   350  34     TPR 2. 
REPEAT   351   384  34     TPR 3. 
MOD_RES   13    13        Phosphoserine. 
MOD_RES   445   445        Phosphoserine. 
STRAND   34    36  3      
STRAND   52    60  9      
STRAND   77    80  4      
HELIX   88    94  7      
STRAND   102   107  6      
HELIX   109   111  3      
TURN   112   116  5      
TURN   119   121  3      
STRAND   128   138  11      
STRAND   144   154  11      
STRAND   167   176  10      
STRAND   179   189  11      
HELIX   193   196  4      
HELIX   200   206  7      
STRAND   214   219  6      
HELIX   221   223  3      
HELIX   231   233  3      
STRAND   241   251  11      
HELIX   256   258  3      
HELIX   261   280  20      
HELIX   284   298  15      
HELIX   306   329  24      
HELIX   333   346  14      
HELIX   351   363  13      
HELIX   367   378  12      
HELIX   387   411  25      
Sequence information
Length: 457 AA [This is the length of the unprocessed precursor] Molecular weight: 51212 Da [This is the MW of the unprocessed precursor] CRC64: 18A86608C6891A73 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG DKVYVHYKGK 

        70         80         90        100        110        120 
LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG EICHLLCKPE YAYGSAGSLP 

       130        140        150        160        170        180 
KIPSNATLFF EIELLDFKGE DLFEDGGIIR RTKRKGEGYS NPNEGATVEI HLEGRCGGRM 

       190        200        210        220        230        240 
FDCRDVAFTV GEGEDHDIPI GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE 

       250        260        270        280        290        300 
LIYEVTLKSF EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM 

       310        320        330        340        350        360 
EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN EKGLYRRGEA 

       370        380        390        400        410        420 
QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE HNERDRRIYA NMFKKFAEQD 

       430        440        450 
AKEEANKAMG KKTSEGVTNE KGTDSQAMEE EKPEGHV 

Q13451 in FASTA format

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