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UniProtKB/Swiss-Prot entry Q13433


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name S39A6_HUMAN
Primary accession number Q13433
Secondary accession numbers Q8IXR3 Q96HP5
Integrated into Swiss-Prot on July 5, 2005
Sequence was last modified on June 1, 2001 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 61)
Name and origin of the protein
Protein name Zinc transporter ZIP6 [Precursor]
Synonyms Zrt- and Irt-like protein 6
ZIP-6
Solute carrier family 39 member 6
Estrogen-regulated protein LIV-1
Gene name
Name: SLC39A6
Synonyms: LIV1, ZIP6
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Green C., Morgan H.E.;
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 376-749 (ISOFORM 1).
TISSUE=Eye, and Lymph;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PROTEIN SEQUENCE OF 29-43.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[4]
INDUCTION.
DOI=10.1016/0303-7207(88)90105-0; PubMed=2903103 [NCBI, ExPASy, EBI, Israel, Japan]
Manning D.L., Daly R.J., Lord P.G., Kelly K.F., Green C.D.;
"Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line.";
Mol. Cell. Endocrinol. 59:205-212(1988).
[5]
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND GLYCOSYLATION.
DOI=10.1042/BJ20030478; PubMed=12839489 [NCBI, ExPASy, EBI, Israel, Japan]
Taylor K.M., Morgan H.E., Johnson A., Hadley L.J., Nicholson R.I.;
"Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.";
Biochem. J. 375:51-59(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U41060; AAA96258.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC008317; AAH08317.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC039498; AAH39498.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00298702; -.
IPI00607564; -.
PIR G02273; G02273.
RefSeq NP_001092876.1; -.
UniGene Hs.79136
3D structure databases
ModBase Q13433.
PTM databases
PhosphoSite Q13433; -.
Organism-specific databases
GeneCards GC18M031943; -.
H-InvDB HIX0014405; -.
HGNC HGNC:18607; SLC39A6.
GenAtlas SLC39A6.
MIM 608731; gene. [NCBI / EBI]
PharmGKB PA134905551; -.
Gene expression databases
ArrayExpress Q13433; -.
Bgee Q13433; -.
CleanEx HS_SLC39A6; -.
GermOnline ENSG00000141424; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0046873; Molecular function: metal ion transmembrane transporter activity (inferred from electronic annotation from InterPro).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006829; Biological process: zinc ion transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR003689; ZIP.
Graphical view of domain structure.
Pfam PF02535; Zip; 1.
Pfam graphical view of domain structure.
Genome annotation databases
Ensembl ENSG00000141424; Homo sapiens. [Contig view]
GeneID 25800; -.
KEGG hsa:25800; -.
Phylogenomic databases
HOGENOM Q13433; -.
HOVERGEN Q13433; -.
Other
NextBio 46997; -.
SOURCE SLC39A6; Homo sapiens.
ProtoNet Q13433.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cell membrane; Coiled coil; Direct protein sequencing; Glycoprotein; Ion transport; Membrane; Signal; Transmembrane; Transport; Zinc; Zinc transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    28  28      
CHAIN   29   749  721     Zinc transporter ZIP6. PRO_0000041650
TOPO_DOM   29   319  291     Extracellular (Potential). 
TRANSMEM   320   340  21     1 (Potential). 
TOPO_DOM   341   349  9     Cytoplasmic (Potential). 
TRANSMEM   350   370  21     2 (Potential). 
TOPO_DOM   371   417  47     Extracellular (Potential). 
TRANSMEM   418   438  21     3 (Potential). 
TOPO_DOM   439   651  213     Cytoplasmic (Potential). 
TRANSMEM   652   672  21     4 (Potential). 
TOPO_DOM   673   680  8     Extracellular (Potential). 
TRANSMEM   681   701  21     5 (Potential). 
TOPO_DOM   702   718  17     Cytoplasmic (Potential). 
TRANSMEM   719   739  21     6 (Potential). 
TOPO_DOM   740   749  10     Extracellular (Potential). 
COILED   458   480  23     Potential. 
COMPBIAS   91   128  38     His-rich. 
COMPBIAS   370   385  16     His-rich. 
COMPBIAS   442   447  6     Poly-Lys. 
COMPBIAS   507   510  4     Poly-Glu. 
COMPBIAS   535   572  38     His-rich. 
CARBOHYD   67    67        N-linked (GlcNAc...) (Potential). 
CARBOHYD   235   235        N-linked (GlcNAc...) (Potential). 
CARBOHYD   260   260        N-linked (GlcNAc...) (Potential). 
CARBOHYD   277   277        N-linked (GlcNAc...) (Potential). 
CARBOHYD   678   678        N-linked (GlcNAc...) (Potential). 
VAR_SEQ   1   269        Missing (in isoform 2). VSP_014309
VAR_SEQ   701   702        PE -> SF (in isoform 2). VSP_014310
VAR_SEQ   703   749        Missing (in isoform 2). VSP_014311
Sequence information
Length: 749 AA [This is the length of the unprocessed precursor] Molecular weight: 84282 Da [This is the MW of the unprocessed precursor] CRC64: 6B48D4E620733F95 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MARKLSVILI LTFALSVTNP LHELKAAAFP QTTEKISPNW ESGINVDLAI STRQYHLQQL 

        70         80         90        100        110        120 
FYRYGENNSL SVEGFRKLLQ NIGIDKIKRI HIHHDHDHHS DHEHHSDHER HSDHEHHSDH 

       130        140        150        160        170        180 
EHHSDHNHAA SGKNKRKALC PDHDSDSSGK DPRNSQGKGA HRPEHASGRR NVKDSVSASE 

       190        200        210        220        230        240 
VTSTVYNTVS EGTHFLETIE TPRPGKLFPK DVSSSTPPSV TSKSRVSRLA GRKTNESVSE 

       250        260        270        280        290        300 
PRKGFMYSRN TNENPQECFN ASKLLTSHGM GIQVPLNATE FNYLCPAIIN QIDARSCLIH 

       310        320        330        340        350        360 
TSEKKAEIPP KTYSLQIAWV GGFIAISIIS FLSLLGVILV PLMNRVFFKF LLSFLVALAV 

       370        380        390        400        410        420 
GTLSGDAFLH LLPHSHASHH HSHSHEEPAM EMKRGPLFSH LSSQNIEESA YFDSTWKGLT 

       430        440        450        460        470        480 
ALGGLYFMFL VEHVLTLIKQ FKDKKKKNQK KPENDDDVEI KKQLSKYESQ LSTNEEKVDT 

       490        500        510        520        530        540 
DDRTEGYLRA DSQEPSHFDS QQPAVLEEEE VMIAHAHPQE VYNEYVPRGC KNKCHSHFHD 

       550        560        570        580        590        600 
TLGQSDDLIH HHHDYHHILH HHHHQNHHPH SHSQRYSREE LKDAGVATLA WMVIMGDGLH 

       610        620        630        640        650        660 
NFSDGLAIGA AFTEGLSSGL STSVAVFCHE LPHELGDFAV LLKAGMTVKQ AVLYNALSAM 

       670        680        690        700        710        720 
LAYLGMATGI FIGHYAENVS MWIFALTAGL FMYVALVDMV PEMLHNDASD HGCSRWGYFF 

       730        740 
LQNAGMLLGF GIMLLISIFE HKIVFRINF 

Q13433 in FASTA format

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