[1]
|
NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 49-66; 81-85; 91-117; 138-145; 148-158; 182-193; 209-229; 438-441 AND 471-481.
TISSUE=Fibrosarcoma;
PubMed=8774743 [NCBI, ExPASy, EBI, Israel, Japan]
Tsurumi C.,
Shimizu Y.,
Saeki M.,
Kato S.,
DeMartino G.N.,
Slaughter C.A.,
Fujimuro M.,
Yokosawa H.,
Yamasaki M.,
Hendil K.B.,
Toh-e A.,
Tanahashi N.,
Tanaka K.;
"cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.";
Eur. J. Biochem. 239:912-921(1996).
|
[2]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung, Muscle, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
|
[3]
|
NUCLEOTIDE SEQUENCE [MRNA] OF 21-908.
PubMed=9126987 [NCBI, ExPASy, EBI, Israel, Japan]
Dunbar J.D.,
Song H.Y.,
Guo D.,
Wu L.-W.,
Donner D.B.;
"Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease.";
J. Immunol. 158:4252-4259(1997).
|
[4]
|
NUCLEOTIDE SEQUENCE [MRNA] OF 10-908.
TISSUE=Liver;
DOI=10.1016/0014-5793(95)00534-G; PubMed=7601280 [NCBI, ExPASy, EBI, Israel, Japan]
Boldin M.P.,
Mett I.L.,
Wallach D.;
"A protein related to a proteasomal subunit binds to the intracellular domain of the p55 TNF receptor upstream to its 'death domain'.";
FEBS Lett. 367:39-44(1995).
|
[5]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND THR-90, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V.,
Blagoev B.,
Gnad F.,
Macek B.,
Kumar C.,
Mortensen P.,
Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
|
[6]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND SER-361, ACETYLATION AT MET-1, AND MASS SPECTROMETRY.
DOI=10.1021/bi061994u; PubMed=17323924 [NCBI, ExPASy, EBI, Israel, Japan]
Wang X.,
Chen C.-F.,
Baker P.R.,
Chen P.-L.,
Kaiser P.,
Huang L.;
"Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.";
Biochemistry 46:3553-3565(2007).
|
[7]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1021/pr070152u; PubMed=17924679 [NCBI, ExPASy, EBI, Israel, Japan]
Yu L.-R.,
Zhu Z.,
Chan K.C.,
Issaq H.J.,
Dimitrov D.S.,
Veenstra T.D.;
"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
J. Proteome Res. 6:4150-4162(2007).
|
|
- FUNCTION: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
- FUNCTION: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
- INTERACTION:
P23508:MCC; NbExp=1; IntAct=EBI-357648, EBI-307531;
Q92597:NDRG1; NbExp=1; IntAct=EBI-357648, EBI-716486;
Q9HC98:NEK6; NbExp=1; IntAct=EBI-357648, EBI-740364;
P43686:PSMC4; NbExp=1; IntAct=EBI-357648, EBI-743997;
O75832:PSMD10; NbExp=1; IntAct=EBI-357648, EBI-752185;
Q15008:PSMD6; NbExp=1; IntAct=EBI-357648, EBI-359701;
Q9BRP4:WDR71; NbExp=1; IntAct=EBI-357648, EBI-1056358;
Q9P2S5:WDR8; NbExp=1; IntAct=EBI-357648, EBI-1054904;
- TISSUE SPECIFICITY: Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.
- SIMILARITY: Belongs to the proteasome subunit S2 family.
- SIMILARITY: Contains 7 PC repeats.
|
ExPASy Home page
SIB Switzerland
