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[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT VAL-1492.
PubMed=10413680 [NCBI, ExPASy, EBI, Israel, Japan]
Kapiloff M.S.,
Shillace R.V.,
Westphal A.M.,
Scott J.D.;
"mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes.";
J. Cell Sci. 112:2725-2736(1999).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1093/dnares/4.2.141; PubMed=9205841 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T.,
Ishikawa K.,
Nakajima D.,
Ohira M.,
Seki N.,
Miyajima N.,
Tanaka A.,
Kotani H.,
Nomura N.,
Ohara O.;
"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.";
DNA Res. 4:141-150(1997).
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[3]
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SEQUENCE REVISION.
DOI=10.1093/dnares/9.3.99; PubMed=12168954 [NCBI, ExPASy, EBI, Israel, Japan]
Nakajima D.,
Okazaki N.,
Yamakawa H.,
Kikuno R.,
Ohara O.,
Nagase T.;
"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.";
DNA Res. 9:99-106(2002).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] OF 1666-2319.
TISSUE=Hippocampus;
DOI=10.1074/jbc.270.16.9327; PubMed=7721854 [NCBI, ExPASy, EBI, Israel, Japan]
McCartney S.,
Little B.M.,
Langeberg L.K.,
Scott J.D.;
"Cloning and characterization of A-kinase anchor protein 100 (AKAP100). A protein that targets A-kinase to the sarcoplasmic reticulum.";
J. Biol. Chem. 270:9327-9333(1995).
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[5]
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VARIANTS [LARGE SCALE ANALYSIS] MET-910; ILE-1192; GLN-1702 AND THR-1839.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T.,
Jones S.,
Wood L.D.,
Parsons D.W.,
Lin J.,
Barber T.D.,
Mandelker D.,
Leary R.J.,
Ptak J.,
Silliman N.,
Szabo S.,
Buckhaults P.,
Farrell C.,
Meeh P.,
Markowitz S.D.,
Willis J.,
Dawson D.,
Willson J.K.V.,
Gazdar A.F., ![]()
Hartigan J.,
Wu L.,
Liu C.,
Parmigiani G.,
Park B.H.,
Bachman K.E.,
Papadopoulos N.,
Vogelstein B.,
Kinzler K.W.,
Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
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- FUNCTION: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.
- SUBUNIT: Interacts with RII subunit of PKA, phosphatase 2B (calcineurin) and AKAP79.
- INTERACTION:
P00519:ABL1; NbExp=1; IntAct=EBI-1056102, EBI-375543;
P46108:CRK; NbExp=1; IntAct=EBI-1056102, EBI-886;
P06241:FYN; NbExp=1; IntAct=EBI-1056102, EBI-515315;
P62993:GRB2; NbExp=1; IntAct=EBI-1056102, EBI-401755;
P16333:NCK1; NbExp=1; IntAct=EBI-1056102, EBI-389883;
P27986:PIK3R1; NbExp=1; IntAct=EBI-1056102, EBI-79464;
P12931:SRC; NbExp=1; IntAct=EBI-1056102, EBI-621482;
- SUBCELLULAR LOCATION: Sarcoplasmic reticulum. Nucleus membrane. Note=In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences.
- TISSUE SPECIFICITY: Highly expressed in cardiac and skeletal muscle, followed by brain.
- DOMAIN: RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
- SIMILARITY: Contains 2 spectrin repeats.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 2319 AA [This is the length of the unprocessed precursor] |
Molecular weight: 256720 Da [This is the MW of the unprocessed precursor] |
CRC64: 7607B71AD2140727 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MLTMSVTLSP LRSQDLDPMA TDASPMAINM TPTVEQGEGE EAMKDMDSDQ QYEKPPPLHT
70 80 90 100 110 120
GADWKIVLHL PEIETWLRMT SERVRDLTYS VQQDSDSKHV DVHLVQLKDI CEDISDHVEQ
130 140 150 160 170 180
IHALLETEFS LKLLSYSVNV IVDIHAVQLL WHQLRVSVLV LRERILQGLQ DANGNYTRQT
190 200 210 220 230 240
DILQAFSEET KEGRLDSLTE VDDSGQLTIK CSQNYLSLDC GITAFELSDY SPSEDLLSGL
250 260 270 280 290 300
GDMTSSQVKT KPFDSWSYSE MEKEFPELIR SVGLLTVAAD SISTNGSEAV TEEVSQVSLS
310 320 330 340 350 360
VDDKGGCEED NASAVEEQPG LTLGVSSSSG EALTNAAQPS SETVQQESSS SSHHDAKNQQ
370 380 390 400 410 420
PVPCENATPK RTIRDCFNYN EDSPTQPTLP KRGLFLKEET FKNDLKGNGG KRQMVDLKPE
430 440 450 460 470 480
MSRSTPSLVD PPDRSKLCLV LQSSYPNSPS AASQSYECLH KVGNGNLENT VKFHIKEISS
490 500 510 520 530 540
SLGRLNDCYK EKSRLKKPHK TSEEVPPCRT PKRGTGSGKQ AKNTKSSAVP NGELSYTSKA
550 560 570 580 590 600
IEGPQTNSAS TSSLEPCNQR SWNAKLQLQS ETSSSPAFTQ SSESSVGSDN IMSPVPLLSK
610 620 630 640 650 660
HKSKKGQASS PSHVTRNGEV VEAWYGSDEY LALPSHLKQT EVLALKLENL TKLLPQKPRG
670 680 690 700 710 720
ETIQNIDDWE LSEMNSDSEI YPTYHVKKKH TRLGRVSPSS SSDIASSLGE SIESGPLSDI
730 740 750 760 770 780
LSDEESSMPL AGMKKYADEK SERASSSEKN ESHSATKSAL IQKLMQDIQH QDNYEAIWEK
790 800 810 820 830 840
IEGFVNKLDE FIQWLNEAME TTENWTPPKA EMDDLKLYLE THLSFKLNVD SHCALKEAVE
850 860 870 880 890 900
EEGHQLLELI ASHKAGLKDM LRMIASQWKE LQRQIKRQHS WILRALDTIK AEILATDVSV
910 920 930 940 950 960
EDEEGTGSPK AEVQLCYLEA QRDAVEQMSL KLYSEQYTSS SKRKEEFADM SKVHSVGSNG
970 980 990 1000 1010 1020
LLDFDSEYQE LWDWLIDMES LVMDSHDLMM SEEQQQHLYK RYSVEMSIRH LKKTELLSKV
1030 1040 1050 1060 1070 1080
EALKKGGVLL PNDLLEKVDS INEKWELLGK TLGEKIQDTM AGHSGSSPRD LLSPESGSLV
1090 1100 1110 1120 1130 1140
RQLEVRIKEL KGWLRDTELF IFNSCLRQEK EGTMNTEKQL QYFKSLCREI KQRRRGVASI
1150 1160 1170 1180 1190 1200
LRLCQHLLDD RETCNLNADH QPMQLIIVNL ERRWEAIVMQ AVQWQTRLQK KMGKESETLN
1210 1220 1230 1240 1250 1260
VIDPGLMDLN GMSEDALEWD EMDISNKLIS LNEESNDLDQ ELQPVIPSLK LGETSNEDPG
1270 1280 1290 1300 1310 1320
YDEEADNHGG SQYASNITAP SSPHIYQVYS LHNVELYEDN HMPFLKNNPK VTGMTQPNVL
1330 1340 1350 1360 1370 1380
TKSLSKDSSF SSTKSLPDLL GGSNLVKPCA CHGGDMSQNS GSESGIVSEG DTETTTNSEM
1390 1400 1410 1420 1430 1440
CLLNAVDGSP SNLETEHLDP QMGDAVNVLK QKFTDEGESI KLPNSSQSSI SPVGCVNGKV
1450 1460 1470 1480 1490 1500
GDLNSITKHT PDCLGEELQG KHDVFTFYDY SYLQGSKLKL PMIMKQSQSE KAHVEDPLLR
1510 1520 1530 1540 1550 1560
GFYFDKKSCK SKHQTTELQP DVPPHERILA SASHEMDRIS YKSGNIEKTF TGMQNAKQLS
1570 1580 1590 1600 1610 1620
LLSHSSSIES LSPGGDLFGL GIFKNGSDSL QRSTSLESWL TSYKSNEDLF SCHSSGDISV
1630 1640 1650 1660 1670 1680
SSGSVGELSK RTLDLLNRLE NIQSPSEQKI KRSVSDITLQ SSSQKMSFTG QMSLDIASSI
1690 1700 1710 1720 1730 1740
NEDSAASLTE LSSSDELSLC SEDIVLHKNK IPESNASFRK RLTRSVADES DVNVSMIVNV
1750 1760 1770 1780 1790 1800
SCTSACTDDE DDSDLLSSST LTLTEEELCI KDEDDDSSIA TDDEIYEDCT LMSGLDYIKN
1810 1820 1830 1840 1850 1860
ELQTWIRPKL SLTRDKKRCN VSDEMKGSKD ISSSEMTNPS DTLNIETLLN GSVKRVSENN
1870 1880 1890 1900 1910 1920
GNGKNSSHTH ELGTKRENKK TIFKVNKDPY VADMENGNIE GIPERQKGKP NVTSKVSENL
1930 1940 1950 1960 1970 1980
GSHGKEISES EHCKCKALMD SLDDSNTAGK EFVSQDVRHL PKKCPNHHHF ENQSTASTPT
1990 2000 2010 2020 2030 2040
EKSFSELALE TRFNNRQDSD ALKSSDDAPS MAGKSAGCCL ALEQNGTEEN ASISNISCCN
2050 2060 2070 2080 2090 2100
CEPDVFHQKD AEDCSVHNFV KEIIDMASTA LKSKSQPENE VAAPTSLTQI KEKVLEHSHR
2110 2120 2130 2140 2150 2160
PIQLRKGDFY SYLSLSSHDS DCGEVTNYIE EKSSTPLPLD TTDSGLDDKE DIECFFEACV
2170 2180 2190 2200 2210 2220
EGDSDGEEPC FSSAPPNESA VPSEAAMPLQ ATACSSEFSD SSLSADDADT VALSSPSSQE
2230 2240 2250 2260 2270 2280
RAEVGKEVNG LPQTSSGCAE NLEFTPSKLD SEKESSGKPG ESGMPEEHNA ASAKSKVQDL
2290 2300 2310
SLKANQPTDK AALHPSPKTL TCEENLLNLH EKRHRNMHR
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Q13023 in FASTA format |
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