[1]
|
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7639698 [NCBI, ExPASy, EBI, Israel, Japan]
Song H.Y.,
Donner D.B.;
"Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor.";
Biochem. J. 309:825-829(1995).
|
[2]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cerebellum;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T.,
Suzuki Y.,
Nishikawa T.,
Otsuki T.,
Sugiyama T.,
Irie R.,
Wakamatsu A.,
Hayashi K.,
Sato H.,
Nagai K.,
Kimura K.,
Makita H.,
Sekine M.,
Obayashi M.,
Nishi T.,
Shibahara T.,
Tanaka T.,
Ishii S.,
Yamamoto J., ![]()
Saito K.,
Kawai Y.,
Isono Y.,
Nakamura Y.,
Nagahari K.,
Murakami K.,
Yasuda T.,
Iwayanagi T.,
Wagatsuma M.,
Shiratori A.,
Sudo H.,
Hosoiri T.,
Kaku Y.,
Kodaira H.,
Kondo H.,
Sugawara M.,
Takahashi M.,
Kanda K.,
Yokoi T.,
Furuya T.,
Kikkawa E.,
Omura Y.,
Abe K.,
Kamihara K.,
Katsuta N.,
Sato K.,
Tanikawa M.,
Yamazaki M.,
Ninomiya K.,
Ishibashi T.,
Yamashita H.,
Murakawa K.,
Fujimori K.,
Tanai H.,
Kimata M.,
Watanabe M.,
Hiraoka S.,
Chiba Y.,
Ishida S.,
Ono Y.,
Takiguchi S.,
Watanabe S.,
Yosida M.,
Hotuta T.,
Kusano J.,
Kanehori K.,
Takahashi-Fujii A.,
Hara H.,
Tanase T.-O.,
Nomura Y.,
Togiya S.,
Komai F.,
Hara R.,
Takeuchi K.,
Arita M.,
Imose N.,
Musashino K.,
Yuuki H.,
Oshima A.,
Sasaki N.,
Aotsuka S.,
Yoshikawa Y.,
Matsunawa H.,
Ichihara T.,
Shiohata N.,
Sano S.,
Moriya S.,
Momiyama H.,
Satoh N.,
Takami S.,
Terashima Y.,
Suzuki O.,
Nakagawa S.,
Senoh A.,
Mizoguchi H.,
Goto Y.,
Shimizu F.,
Wakebe H.,
Hishigaki H.,
Watanabe T.,
Sugiyama A.,
Takemoto M.,
Kawakami B.,
Yamazaki M.,
Watanabe K.,
Kumagai A.,
Itakura S.,
Fukuzumi Y.,
Fujimori Y.,
Komiyama M.,
Tashiro H.,
Tanigami A.,
Fujiwara T.,
Ono T.,
Yamada K.,
Fujii Y.,
Ozaki K.,
Hirao M.,
Ohmori Y.,
Kawabata A.,
Hikiji T.,
Kobatake N.,
Inagaki H.,
Ikema Y.,
Okamoto S.,
Okitani R.,
Kawakami T.,
Noguchi S.,
Itoh T.,
Shigeta K.,
Senba T.,
Matsumura K.,
Nakajima Y.,
Mizuno T.,
Morinaga M.,
Sasaki M.,
Togashi T.,
Oyama M.,
Hata H.,
Watanabe M.,
Komatsu T.,
Mizushima-Sugano J.,
Satoh T.,
Shirai Y.,
Takahashi Y.,
Nakagawa K.,
Okumura K.,
Nagase T.,
Nomura N.,
Kikuchi H.,
Masuho Y.,
Yamashita R.,
Nakai K.,
Yada T.,
Nakamura Y.,
Ohara O.,
Isogai T.,
Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
|
[3]
|
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
SeattleSNPs program for genomic applications;
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
|
[4]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Colon, Fetal brain, Kidney, Leukocyte, Stomach, and Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
|
[5]
|
NUCLEOTIDE SEQUENCE [MRNA] OF 201-501, AND INTERACTION WITH TRAF1 AND TNFRSF1B.
DOI=10.1016/0092-8674(94)90532-0; PubMed=8069916 [NCBI, ExPASy, EBI, Israel, Japan]
Rothe M.,
Wong S.C.,
Henzel W.J.,
Goeddel D.V.;
"A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.";
Cell 78:681-692(1994).
|
[6]
|
INTERACTION WITH TBK1.
TISSUE=Spleen;
DOI=10.1093/emboj/18.23.6694; PubMed=10581243 [NCBI, ExPASy, EBI, Israel, Japan]
Pomerantz J.L.,
Baltimore D.;
"NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase.";
EMBO J. 18:6694-6704(1999).
|
[7]
|
REVIEW.
DOI=10.1016/S0898-6568(01)00160-7; PubMed=11384837 [NCBI, ExPASy, EBI, Israel, Japan]
Wajant H.,
Henkler F.,
Scheurich P.;
"The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.";
Cell. Signal. 13:389-400(2001).
|
[8]
|
REVIEW.
DOI=10.1038/sj.onc.1204788; PubMed=11607847 [NCBI, ExPASy, EBI, Israel, Japan]
Bradley J.R.,
Pober J.S.;
"Tumor necrosis factor receptor-associated factors (TRAFs).";
Oncogene 20:6482-6491(2001).
|
[9]
|
INTERACTION WITH TNFRSF8.
DOI=10.1084/jem.183.2.669; PubMed=8627180 [NCBI, ExPASy, EBI, Israel, Japan]
Lee S.Y.,
Park C.G.,
Choi Y.;
"T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors.";
J. Exp. Med. 183:669-674(1996).
|
[10]
|
INTERACTION WITH TANK.
DOI=10.1073/pnas.93.16.8241; PubMed=8710854 [NCBI, ExPASy, EBI, Israel, Japan]
Rothe M.,
Xiong J.,
Shu H.-B.,
Williamson K.,
Goddard A.,
Goeddel D.V.;
"I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.";
Proc. Natl. Acad. Sci. U.S.A. 93:8241-8246(1996).
|
[11]
|
INTERACTION WITH TNFRSF14.
DOI=10.1074/jbc.272.21.13471; PubMed=9153189 [NCBI, ExPASy, EBI, Israel, Japan]
Hsu H.,
Solovyev I.,
Colombero A.,
Elliott R.,
Kelley M.,
Boyle W.J.;
"ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5.";
J. Biol. Chem. 272:13471-13474(1997).
|
[12]
|
INTERACTION WITH TRIP.
DOI=10.1084/jem.185.7.1275; PubMed=9104814 [NCBI, ExPASy, EBI, Israel, Japan]
Lee S.Y.,
Lee S.Y.,
Choi Y.;
"TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation.";
J. Exp. Med. 185:1275-1285(1997).
|
[13]
|
INTERACTION WITH MAP3K14.
DOI=10.1038/385540a0; PubMed=9020361 [NCBI, ExPASy, EBI, Israel, Japan]
Malinin N.L.,
Boldin M.P.,
Kovalenko A.V.,
Wallach D.;
"MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.";
Nature 385:540-544(1997).
|
[14]
|
INTERACTION WITH TNFRSF5.
DOI=10.1021/bi981067q; PubMed=9718306 [NCBI, ExPASy, EBI, Israel, Japan]
Pullen S.S.,
Miller H.G.,
Everdeen D.S.,
Dang T.T.,
Crute J.J.,
Kehry M.R.;
"CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.";
Biochemistry 37:11836-11845(1998).
|
[15]
|
INTERACTION WITH RIPK2.
DOI=10.1016/S0960-9822(07)00352-1; PubMed=9705938 [NCBI, ExPASy, EBI, Israel, Japan]
Thome M.,
Hofmann K.,
Burns K.,
Martinon F.,
Bodmer J.-L.,
Mattmann C.,
Tschopp J.;
"Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.";
Curr. Biol. 8:885-888(1998).
|
[16]
|
INTERACTION WITH CD27.
DOI=10.1002/(SICI)1521-4141(199807)28:07<2208::AID-IMMU2208>3.0.CO;2-L; PubMed=9692890 [NCBI, ExPASy, EBI, Israel, Japan]
Gravestein L.A.,
Amsen D.,
Boes M.,
Calvo C.R.,
Kruisbeek A.M.,
Borst J.;
"The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2.";
Eur. J. Immunol. 28:2208-2216(1998).
|
[17]
|
INTERACTION WITH TNFRSF4 AND TNFRSF9.
PubMed=9418902 [NCBI, ExPASy, EBI, Israel, Japan]
Arch R.H.,
Thompson C.B.;
"4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.";
Mol. Cell. Biol. 18:558-565(1998).
|
[18]
|
INTERACTION WITH TNFRSF4.
DOI=10.1074/jbc.273.10.5808; PubMed=9488716 [NCBI, ExPASy, EBI, Israel, Japan]
Kawamata S.,
Hori T.,
Imura A.,
Takaori-Kondo A.,
Uchiyama T.;
"Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.";
J. Biol. Chem. 273:5808-5814(1998).
|
[19]
|
INTERACTION WITH TNFRSF11A.
DOI=10.1074/jbc.273.43.28355; PubMed=9774460 [NCBI, ExPASy, EBI, Israel, Japan]
Wong B.R.,
Josien R.,
Lee S.Y.,
Vologodskaia M.,
Steinman R.M.,
Choi Y.;
"The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.";
J. Biol. Chem. 273:28355-28359(1998).
|
[20]
|
INTERACTION WITH TNFRSF9.
DOI=10.1084/jem.187.11.1849; PubMed=9607925 [NCBI, ExPASy, EBI, Israel, Japan]
Saoulli K.,
Lee S.Y.,
Cannons J.L.,
Yeh W.C.,
Santana A.,
Goldstein M.D.,
Bangia N.,
DeBenedette M.A.,
Mak T.W.,
Choi Y.,
Watts T.H.;
"CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand.";
J. Exp. Med. 187:1849-1862(1998).
|
[21]
|
INTERACTION WITH MAP3K5.
DOI=10.1016/S1097-2765(00)80283-X; PubMed=9774977 [NCBI, ExPASy, EBI, Israel, Japan]
Nishitoh H.,
Saitoh M.,
Mochida Y.,
Takeda K.,
Nakano H.,
Rothe M.,
Miyazono K.,
Ichijo H.;
"ASK1 is essential for JNK/SAPK activation by TRAF2.";
Mol. Cell 2:389-395(1998).
|
[22]
|
INTERACTION WITH IL15RA.
PubMed=10463949 [NCBI, ExPASy, EBI, Israel, Japan]
Bulfone-Paus S.,
Bulanova E.,
Pohl T.,
Budagian V.,
Duerkop H.,
Rueckert R.,
Kunzendorf U.,
Paus R.,
Krause H.;
"Death deflected: IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Ralpha chain.";
FASEB J. 13:1575-1585(1999).
|
[23]
|
INTERACTION WITH TNFRSF18.
TISSUE=T-cell;
DOI=10.1074/jbc.274.10.6056; PubMed=10037686 [NCBI, ExPASy, EBI, Israel, Japan]
Kwon B.,
Yu K.-Y.,
Ni J.,
Yu G.-L.,
Jang I.-K.,
Kim Y.-J.,
Xing L.,
Liu D.,
Wang S.-X.,
Kwon B.S.;
"Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand.";
J. Biol. Chem. 274:6056-6061(1999).
|
[24]
|
INTERACTION WITH TNFRSF16.
DOI=10.1074/jbc.274.42.30202; PubMed=10514511 [NCBI, ExPASy, EBI, Israel, Japan]
Ye X.,
Mehlen P.,
Rabizadeh S.,
VanArsdale T.,
Zhang H.,
Shin H.,
Wang J.J.L.,
Leo E.,
Zapata J.M.,
Hauser C.A.,
Reed J.C.,
Bredesen D.E.;
"TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.";
J. Biol. Chem. 274:30202-30208(1999).
|
[25]
|
INTERACTION WITH TNIK.
DOI=10.1074/jbc.274.43.30729; PubMed=10521462 [NCBI, ExPASy, EBI, Israel, Japan]
Fu C.A.,
Shen M.,
Huang B.C.,
Lasaga J.,
Payan D.G.,
Luo Y.;
"TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton.";
J. Biol. Chem. 274:30729-30737(1999).
|
[26]
|
INTERACTION WITH CDK9.
DOI=10.1002/(SICI)1097-4644(19981215)71:4<467::AID-JCB2>3.3.CO;2-7; PubMed=9827693 [NCBI, ExPASy, EBI, Israel, Japan]
MacLachlan T.K.,
Sang N.,
De Luca A.,
Puri P.L.,
Levrero M.,
Giordano A.;
"Binding of CDK9 to TRAF2.";
J. Cell. Biochem. 71:467-478(1998).
|
[27]
|
INTERACTION WITH TNFRSF19.
DOI=10.1074/jbc.275.20.15336; PubMed=10809768 [NCBI, ExPASy, EBI, Israel, Japan]
Eby M.T.,
Jasmin A.,
Kumar A.,
Sharma K.,
Chaudhary P.M.;
"TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death.";
J. Biol. Chem. 275:15336-15342(2000).
|
[28]
|
INTERACTION WITH TNFRSF13B.
DOI=10.1084/jem.192.1.137; PubMed=10880535 [NCBI, ExPASy, EBI, Israel, Japan]
Xia X.-Z.,
Treanor J.,
Senaldi G.,
Khare S.D.,
Boone T.,
Kelley M.,
Theill L.E.,
Colombero A.,
Solovyev I.,
Lee F.,
McCabe S.,
Elliott R.,
Miner K.,
Hawkins N.,
Guo J.,
Stolina M.,
Yu G.,
Wang J.,
Delaney J., ![]()
Meng S.-Y.,
Boyle W.J.,
Hsu H.;
"TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation.";
J. Exp. Med. 192:137-143(2000).
|
[29]
|
INTERACTION WITH MAP4K2.
PubMed=11784851 [NCBI, ExPASy, EBI, Israel, Japan]
Chadee D.N.,
Yuasa T.,
Kyriakis J.M.;
"Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.";
Mol. Cell. Biol. 22:737-749(2002).
|
[30]
|
INTERACTION WITH MAP3K1.
PubMed=10346818 [NCBI, ExPASy, EBI, Israel, Japan]
Baud V.,
Liu Z.-G.,
Bennett B.,
Suzuki N.,
Xia Y.,
Karin M.;
"Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.";
Genes Dev. 13:1297-1308(1999).
|
[31]
|
INTERACTION WITH TTRAP.
DOI=10.1074/jbc.M000531200; PubMed=10764746 [NCBI, ExPASy, EBI, Israel, Japan]
Pype S.,
Declercq W.,
Ibrahimi A.,
Michiels C.,
Van Rietschoten J.G.I.,
Dewulf N.,
de Boer M.,
Vandenabeele P.,
Huylebroeck D.,
Remacle J.E.;
"TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.";
J. Biol. Chem. 275:18586-18593(2000).
|
[32]
|
INTERACTION WITH SIAH2, AND DEGRADATION.
DOI=10.1093/emboj/cdf576; PubMed=12411493 [NCBI, ExPASy, EBI, Israel, Japan]
Habelhah H.,
Frew I.J.,
Laine A.,
Janes P.W.,
Relaix F.,
Sassoon D.,
Bowtell D.D.L.,
Ronai Z.;
"Stress-induced decrease in TRAF2 stability is mediated by Siah2.";
EMBO J. 21:5756-5765(2002).
|
[33]
|
INTERACTION WITH CYLD.
DOI=10.1038/nature01802; PubMed=12917691 [NCBI, ExPASy, EBI, Israel, Japan]
Kovalenko A.,
Chable-Bessia C.,
Cantarella G.,
Israeel A.,
Wallach D.,
Courtois G.;
"The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.";
Nature 424:801-805(2003).
|
[34]
|
INTERACTION WITH DAB2IP.
DOI=10.1074/jbc.M407617200; PubMed=15310755 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang H.,
Zhang R.,
Luo Y.,
D'Alessio A.,
Pober J.S.,
Min W.;
"AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.";
J. Biol. Chem. 279:44955-44965(2004).
|
[35]
|
INTERACTION WITH MAVS.
DOI=10.1016/j.molcel.2005.08.014; PubMed=16153868 [NCBI, ExPASy, EBI, Israel, Japan]
Xu L.-G.,
Wang Y.-Y.,
Han K.-J.,
Li L.-Y.,
Zhai Z.,
Shu H.-B.;
"VISA is an adapter protein required for virus-triggered IFN-beta Signaling.";
Mol. Cell 19:727-740(2005).
|
[36]
|
INTERACTION WITH USP48.
DOI=10.1016/j.cellsig.2005.03.017; PubMed=16214042 [NCBI, ExPASy, EBI, Israel, Japan]
Tzimas C.,
Michailidou G.,
Arsenakis M.,
Kieff E.,
Mosialos G.,
Hatzivassiliou E.G.;
"Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB.";
Cell. Signal. 18:83-92(2006).
|
[37]
|
X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 310-501 IN COMPLEX WITH TNFRSF1B.
DOI=10.1038/19110; PubMed=10206649 [NCBI, ExPASy, EBI, Israel, Japan]
Park Y.C.,
Burkitt V.,
Villa A.R.,
Tong L.,
Wu H.;
"Structural basis for self-association and receptor recognition of human TRAF2.";
Nature 398:533-538(1999).
|
[38]
|
X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 334-501 IN COMPLEX WITH EBV BNFL1, X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 315-501 IN COMPLEX WITH TNFRSF5, X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 334-501 IN COMPLEX WITH TNFRSF4, AND X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 334-501 IN COMPLEX WITH TNFRSF9.
DOI=10.1073/pnas.96.15.8408; PubMed=10411888 [NCBI, ExPASy, EBI, Israel, Japan]
McWhirter S.M.,
Pullen S.S.,
Holton J.M.,
Crute J.J.,
Kehry M.R.,
Alber T.;
"Crystallographic analysis of CD40 recognition and signaling by human TRAF2.";
Proc. Natl. Acad. Sci. U.S.A. 96:8408-8413(1999).
|
[39]
|
X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 331-501 IN COMPLEX WITH TRADD.
DOI=10.1016/S0092-8674(00)80889-2; PubMed=10892748 [NCBI, ExPASy, EBI, Israel, Japan]
Park Y.C.,
Ye H.,
Hsia C.,
Segal D.,
Rich R.L.,
Liou H.C.,
Myszka D.G.,
Wu H.;
"A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction.";
Cell 101:777-787(2000).
|
|
ExPASy Home page
